Radiotherapeutic options for hepatocellular carcinoma with portal vein tumor thrombosis

Dong Soo Lee, Jinsil Seong

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Portal vein tumor thrombosis (PVTT) is a common paraneoplastic condition in advanced primary hepatocellular carcinoma or hepatobiliary tract malignancies. Tumors with PVTT are frequently associated with adverse and aggressive features such as intrahepatic tumor dissemination, early treatment failure, or deterioration of hepatic function. Therefore, the treatment outcomes for PVTT in historical series are often dismal and discouraging. More recently, beneficial effects and excellent outcomes of external beam radiation therapy (EBRT) for treating this disease have been reported, and the use of EBRT is becoming more common because of the non-invasive nature of RT and rapid advances in RT technology. We hope to be able to cure this devastating condition in the near future with more advanced and efficacious disease management strategies. The current status and clinical trial results for EBRT as a promising treatment option for managing PVTT will be discussed here.

Original languageEnglish
Pages (from-to)18-30
Number of pages13
JournalLiver Cancer
Volume3
Issue number1
DOIs
Publication statusPublished - 2014 Apr 18

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Portal Vein
Hepatocellular Carcinoma
Thrombosis
Neoplasms
Radiotherapy
Disease Management
Treatment Failure
Clinical Trials
Technology
Liver

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Oncology

Cite this

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abstract = "Portal vein tumor thrombosis (PVTT) is a common paraneoplastic condition in advanced primary hepatocellular carcinoma or hepatobiliary tract malignancies. Tumors with PVTT are frequently associated with adverse and aggressive features such as intrahepatic tumor dissemination, early treatment failure, or deterioration of hepatic function. Therefore, the treatment outcomes for PVTT in historical series are often dismal and discouraging. More recently, beneficial effects and excellent outcomes of external beam radiation therapy (EBRT) for treating this disease have been reported, and the use of EBRT is becoming more common because of the non-invasive nature of RT and rapid advances in RT technology. We hope to be able to cure this devastating condition in the near future with more advanced and efficacious disease management strategies. The current status and clinical trial results for EBRT as a promising treatment option for managing PVTT will be discussed here.",
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Radiotherapeutic options for hepatocellular carcinoma with portal vein tumor thrombosis. / Lee, Dong Soo; Seong, Jinsil.

In: Liver Cancer, Vol. 3, No. 1, 18.04.2014, p. 18-30.

Research output: Contribution to journalArticle

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