Radiotherapy as an immune checkpoint blockade combination strategy for hepatocellular carcinoma

Byung Min Lee, Jinsil Seong

Research output: Contribution to journalReview articlepeer-review

Abstract

In the immune oncology era, the clinical efficacy of immune checkpoint inhibitors (ICIs) against most solid cancers is well known. In hepatocellular carcinoma, the recent success of combination therapy with targeting agents has accelerated the search for novel combination strategies. Radiotherapy (RT), an attractive modality, can be combined with ICIs, which act as strong modulators of the tumor immune microenvironment. Herein, we discuss immune modulation caused by radiation and the current trials of RT–ICI combination treatment as well as future perspectives.

Original languageEnglish
Pages (from-to)919-927
Number of pages9
JournalWorld Journal of Gastroenterology
Volume27
Issue number10
DOIs
Publication statusPublished - 2021 Mar 14

Bibliographical note

Publisher Copyright:
©The Author(s) 2021.

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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