Radiotherapy for Hepatocellular Carcinoma

New Indications and Directions for Future Study

Nitin Ohri, Laura A. Dawson, Sunil Krishnan, Jinsil Seong, Jason C. Cheng, Shiv K. Sarin, Milan Kinkhabwala, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Chandan Guha

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide; its incidence is increasing in the United States. Depending on disease extent and underlying liver status, patients may be treated with local, locoregional, and/or systemic therapy. Recent data indicates that radiotherapy (RT) can play a meaningful role in the management of HCC. Here, we review published experiences using RT for HCC, including the use of radiosensitizers and stereotactic RT. We discuss methods for performing preclinical studies of RT for HCC and biomarkers of response. As a part of the HCC Working Group, an informal committee of the National Cancer Institute's Radiation Research Program, we suggest how RT should be implemented in the management of HCC and identify future directions for the study of RT in HCC.

Original languageEnglish
Article numberdjw133
JournalJournal of the National Cancer Institute
Volume108
Issue number9
DOIs
Publication statusPublished - 2016 Sep 1

Fingerprint

Hepatocellular Carcinoma
Radiotherapy
National Cancer Institute (U.S.)
Direction compound
Cause of Death
Biomarkers
Radiation
Liver
Incidence
Research
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ohri, Nitin ; Dawson, Laura A. ; Krishnan, Sunil ; Seong, Jinsil ; Cheng, Jason C. ; Sarin, Shiv K. ; Kinkhabwala, Milan ; Ahmed, Mansoor M. ; Vikram, Bhadrasain ; Coleman, C. Norman ; Guha, Chandan. / Radiotherapy for Hepatocellular Carcinoma : New Indications and Directions for Future Study. In: Journal of the National Cancer Institute. 2016 ; Vol. 108, No. 9.
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Ohri, N, Dawson, LA, Krishnan, S, Seong, J, Cheng, JC, Sarin, SK, Kinkhabwala, M, Ahmed, MM, Vikram, B, Coleman, CN & Guha, C 2016, 'Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study', Journal of the National Cancer Institute, vol. 108, no. 9, djw133. https://doi.org/10.1093/jnci/djw133

Radiotherapy for Hepatocellular Carcinoma : New Indications and Directions for Future Study. / Ohri, Nitin; Dawson, Laura A.; Krishnan, Sunil; Seong, Jinsil; Cheng, Jason C.; Sarin, Shiv K.; Kinkhabwala, Milan; Ahmed, Mansoor M.; Vikram, Bhadrasain; Coleman, C. Norman; Guha, Chandan.

In: Journal of the National Cancer Institute, Vol. 108, No. 9, djw133, 01.09.2016.

Research output: Contribution to journalReview article

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AU - Ohri, Nitin

AU - Dawson, Laura A.

AU - Krishnan, Sunil

AU - Seong, Jinsil

AU - Cheng, Jason C.

AU - Sarin, Shiv K.

AU - Kinkhabwala, Milan

AU - Ahmed, Mansoor M.

AU - Vikram, Bhadrasain

AU - Coleman, C. Norman

AU - Guha, Chandan

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