Radiotherapy for solitary plasmacytoma of bone and soft tissue: Outcomes and prognostic factors

Yang Gun Suh, Chang Ok Suh, Jin Seok Kim, Soo Jeong Kim, Hae Ok Pyun, Jaeho Cho

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We investigated treatment outcomes of radiotherapy for solitary plasmacytoma (SP) and prognostic factors affecting survival. Between 1996 and 2010, a total of 38 patients were treated with radiotherapy for histologically proven plasmacytoma without evidence of multiple myeloma. Among these, 16 and 22 patients had SP originating from extramedullary soft tissue (EMP) and bone, respectively. Thirteen patients received adjuvant chemotherapy, and three patients underwent surgery prior to radiotherapy. At a median follow-up of 50 months (range, 8-142), radiotherapy demonstrated excellent local control (5- and 10-year local control rates, 81 %). However, the 10-year multiple myeloma-free survival (MMFS) was 54 % and the 10-year overall survival (OS) rates was 35 %. Solitary bone plasmacytoma (SBP) more frequently progressed to multiple myeloma (MM) than EMP (10-year MMFS, 0 % vs. 71 %, p= 0.02). Radiotherapy with doses ≥40 Gy demonstrated better local control (10-year LC, 100 % vs. 60 %, p= 0.04) in SBP. In the multivariate analysis, elevated β2- microglobulin was a significantly unfavorable prognostic factor affecting OS (p=0.03). In conclusion, radiotherapy effectively treated SP without significant toxicity. However, progression to MM presents a challenging problem. Novel therapeutics are needed for patients with unfavorable prognostic factors.

Original languageEnglish
Pages (from-to)1785-1793
Number of pages9
JournalAnnals of Hematology
Volume91
Issue number11
DOIs
Publication statusPublished - 2012 Nov 1

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Plasmacytoma
Thromboplastin
Multiple Myeloma
Radiotherapy
Bone and Bones
Survival
Adjuvant Chemotherapy
Multivariate Analysis
Survival Rate

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

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title = "Radiotherapy for solitary plasmacytoma of bone and soft tissue: Outcomes and prognostic factors",
abstract = "We investigated treatment outcomes of radiotherapy for solitary plasmacytoma (SP) and prognostic factors affecting survival. Between 1996 and 2010, a total of 38 patients were treated with radiotherapy for histologically proven plasmacytoma without evidence of multiple myeloma. Among these, 16 and 22 patients had SP originating from extramedullary soft tissue (EMP) and bone, respectively. Thirteen patients received adjuvant chemotherapy, and three patients underwent surgery prior to radiotherapy. At a median follow-up of 50 months (range, 8-142), radiotherapy demonstrated excellent local control (5- and 10-year local control rates, 81 {\%}). However, the 10-year multiple myeloma-free survival (MMFS) was 54 {\%} and the 10-year overall survival (OS) rates was 35 {\%}. Solitary bone plasmacytoma (SBP) more frequently progressed to multiple myeloma (MM) than EMP (10-year MMFS, 0 {\%} vs. 71 {\%}, p= 0.02). Radiotherapy with doses ≥40 Gy demonstrated better local control (10-year LC, 100 {\%} vs. 60 {\%}, p= 0.04) in SBP. In the multivariate analysis, elevated β2- microglobulin was a significantly unfavorable prognostic factor affecting OS (p=0.03). In conclusion, radiotherapy effectively treated SP without significant toxicity. However, progression to MM presents a challenging problem. Novel therapeutics are needed for patients with unfavorable prognostic factors.",
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Radiotherapy for solitary plasmacytoma of bone and soft tissue : Outcomes and prognostic factors. / Suh, Yang Gun; Suh, Chang Ok; Kim, Jin Seok; Kim, Soo Jeong; Pyun, Hae Ok; Cho, Jaeho.

In: Annals of Hematology, Vol. 91, No. 11, 01.11.2012, p. 1785-1793.

Research output: Contribution to journalArticle

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T1 - Radiotherapy for solitary plasmacytoma of bone and soft tissue

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AU - Suh, Chang Ok

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AU - Cho, Jaeho

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