Radiotherapy versus cordectomy in the management of early glottic cancer

Seung Yeun Chung, Kyung Hwan Kim, Ki Chang Keum, Yoon Woo Koh, Se Heon Kim, Eun Chang Choi, Chang Geol Lee

Research output: Contribution to journalArticle

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Abstract

Purpose The purpose of this study was to compare the treatment outcomes of definitive radiotherapy (RT) with cordectomy in patients with early glottic cancer. Materials and Methods A total of 165 patients who were diagnosed with T1/2 squamous cell carcinoma of the glottic larynx between January 2006 and December 2012 were retrospectively analyzed. A total of 112 patients received RT and 53 patients received cordectomy. Local control (LC), diseasefree survival (DFS), overall survival (OS), and larynx preservation rates after RT and cordectomy were investigated. Results The median follow-up period was 77.7 months (range, 10.7 to 127.0 months). The 3- and 5-year LC rates were 91.9% and 89.9%, respectively, for the RT group, and 82.8% and 73.2%, respectively, for the cordectomy group (p=0.006). The 3- and 5-year DFS rates were 87.5% and 83.7%, respectively, for the RT group and 79.2% and 68.0%, respectively, for the cordectomy group (p=0.046). No significant differences were identified in the 5-year OS (92.8% vs. 90.6%, p=0.713) or larynx preservation rates (98.2% vs. 97.2%, p=0.831) between groups. The major failure pattern was local failure (n=26), followed by regional (n=3) and distant failure (n=2). Multivariate analysis of LC showed that T2 stage (p=0.012) and receiving cordectomy as initial treatment (p=0.001) were significantly associated with poorer LC. Conclusion RT resulted in higher rates of LC and DFS compared to cordectomy for early glottic cancer. Treatment with radiotherapy is feasible and should be encouraged for both T1 and T2 glottic cancer.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalCancer Research and Treatment
Volume50
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

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Tongue Neoplasms
Radiotherapy
Larynx
Survival
Tongue
Squamous Cell Carcinoma
Multivariate Analysis
Survival Rate
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Chung, S. Y., Kim, K. H., Keum, K. C., Koh, Y. W., Kim, S. H., Choi, E. C., & Lee, C. G. (2018). Radiotherapy versus cordectomy in the management of early glottic cancer. Cancer Research and Treatment, 50(1), 156-163. https://doi.org/10.4143/crt.2016.503
Chung, Seung Yeun ; Kim, Kyung Hwan ; Keum, Ki Chang ; Koh, Yoon Woo ; Kim, Se Heon ; Choi, Eun Chang ; Lee, Chang Geol. / Radiotherapy versus cordectomy in the management of early glottic cancer. In: Cancer Research and Treatment. 2018 ; Vol. 50, No. 1. pp. 156-163.
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title = "Radiotherapy versus cordectomy in the management of early glottic cancer",
abstract = "Purpose The purpose of this study was to compare the treatment outcomes of definitive radiotherapy (RT) with cordectomy in patients with early glottic cancer. Materials and Methods A total of 165 patients who were diagnosed with T1/2 squamous cell carcinoma of the glottic larynx between January 2006 and December 2012 were retrospectively analyzed. A total of 112 patients received RT and 53 patients received cordectomy. Local control (LC), diseasefree survival (DFS), overall survival (OS), and larynx preservation rates after RT and cordectomy were investigated. Results The median follow-up period was 77.7 months (range, 10.7 to 127.0 months). The 3- and 5-year LC rates were 91.9{\%} and 89.9{\%}, respectively, for the RT group, and 82.8{\%} and 73.2{\%}, respectively, for the cordectomy group (p=0.006). The 3- and 5-year DFS rates were 87.5{\%} and 83.7{\%}, respectively, for the RT group and 79.2{\%} and 68.0{\%}, respectively, for the cordectomy group (p=0.046). No significant differences were identified in the 5-year OS (92.8{\%} vs. 90.6{\%}, p=0.713) or larynx preservation rates (98.2{\%} vs. 97.2{\%}, p=0.831) between groups. The major failure pattern was local failure (n=26), followed by regional (n=3) and distant failure (n=2). Multivariate analysis of LC showed that T2 stage (p=0.012) and receiving cordectomy as initial treatment (p=0.001) were significantly associated with poorer LC. Conclusion RT resulted in higher rates of LC and DFS compared to cordectomy for early glottic cancer. Treatment with radiotherapy is feasible and should be encouraged for both T1 and T2 glottic cancer.",
author = "Chung, {Seung Yeun} and Kim, {Kyung Hwan} and Keum, {Ki Chang} and Koh, {Yoon Woo} and Kim, {Se Heon} and Choi, {Eun Chang} and Lee, {Chang Geol}",
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Chung, SY, Kim, KH, Keum, KC, Koh, YW, Kim, SH, Choi, EC & Lee, CG 2018, 'Radiotherapy versus cordectomy in the management of early glottic cancer', Cancer Research and Treatment, vol. 50, no. 1, pp. 156-163. https://doi.org/10.4143/crt.2016.503

Radiotherapy versus cordectomy in the management of early glottic cancer. / Chung, Seung Yeun; Kim, Kyung Hwan; Keum, Ki Chang; Koh, Yoon Woo; Kim, Se Heon; Choi, Eun Chang; Lee, Chang Geol.

In: Cancer Research and Treatment, Vol. 50, No. 1, 01.01.2018, p. 156-163.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Radiotherapy versus cordectomy in the management of early glottic cancer

AU - Chung, Seung Yeun

AU - Kim, Kyung Hwan

AU - Keum, Ki Chang

AU - Koh, Yoon Woo

AU - Kim, Se Heon

AU - Choi, Eun Chang

AU - Lee, Chang Geol

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose The purpose of this study was to compare the treatment outcomes of definitive radiotherapy (RT) with cordectomy in patients with early glottic cancer. Materials and Methods A total of 165 patients who were diagnosed with T1/2 squamous cell carcinoma of the glottic larynx between January 2006 and December 2012 were retrospectively analyzed. A total of 112 patients received RT and 53 patients received cordectomy. Local control (LC), diseasefree survival (DFS), overall survival (OS), and larynx preservation rates after RT and cordectomy were investigated. Results The median follow-up period was 77.7 months (range, 10.7 to 127.0 months). The 3- and 5-year LC rates were 91.9% and 89.9%, respectively, for the RT group, and 82.8% and 73.2%, respectively, for the cordectomy group (p=0.006). The 3- and 5-year DFS rates were 87.5% and 83.7%, respectively, for the RT group and 79.2% and 68.0%, respectively, for the cordectomy group (p=0.046). No significant differences were identified in the 5-year OS (92.8% vs. 90.6%, p=0.713) or larynx preservation rates (98.2% vs. 97.2%, p=0.831) between groups. The major failure pattern was local failure (n=26), followed by regional (n=3) and distant failure (n=2). Multivariate analysis of LC showed that T2 stage (p=0.012) and receiving cordectomy as initial treatment (p=0.001) were significantly associated with poorer LC. Conclusion RT resulted in higher rates of LC and DFS compared to cordectomy for early glottic cancer. Treatment with radiotherapy is feasible and should be encouraged for both T1 and T2 glottic cancer.

AB - Purpose The purpose of this study was to compare the treatment outcomes of definitive radiotherapy (RT) with cordectomy in patients with early glottic cancer. Materials and Methods A total of 165 patients who were diagnosed with T1/2 squamous cell carcinoma of the glottic larynx between January 2006 and December 2012 were retrospectively analyzed. A total of 112 patients received RT and 53 patients received cordectomy. Local control (LC), diseasefree survival (DFS), overall survival (OS), and larynx preservation rates after RT and cordectomy were investigated. Results The median follow-up period was 77.7 months (range, 10.7 to 127.0 months). The 3- and 5-year LC rates were 91.9% and 89.9%, respectively, for the RT group, and 82.8% and 73.2%, respectively, for the cordectomy group (p=0.006). The 3- and 5-year DFS rates were 87.5% and 83.7%, respectively, for the RT group and 79.2% and 68.0%, respectively, for the cordectomy group (p=0.046). No significant differences were identified in the 5-year OS (92.8% vs. 90.6%, p=0.713) or larynx preservation rates (98.2% vs. 97.2%, p=0.831) between groups. The major failure pattern was local failure (n=26), followed by regional (n=3) and distant failure (n=2). Multivariate analysis of LC showed that T2 stage (p=0.012) and receiving cordectomy as initial treatment (p=0.001) were significantly associated with poorer LC. Conclusion RT resulted in higher rates of LC and DFS compared to cordectomy for early glottic cancer. Treatment with radiotherapy is feasible and should be encouraged for both T1 and T2 glottic cancer.

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DO - 10.4143/crt.2016.503

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