Randomised controlled clinical trial of augmentation of the alveolar ridge using recombinant human bone morphogenetic protein 2 with hydroxyapatite and bovine-derived xenografts: comparison of changes in volume

J. W. Nam, S. Khureltogtokh, H. M. Choi, A. R. Lee, Y. B. Park, H. J. Kim

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The aim of this randomised controlled clinical trial was to assess the early efficacy of bone morphogenetic protein-2 with hydroxyapatite granules (BMP-2/hydroxyapatite) on augmentation of the alveolar ridge, by comparing changes in volume with those associated with the use of an inorganic bovine-derived xenograft (BDX). We studied 20 patients who were divided into two groups using a table of random numbers, and BMP-2/hydroxyapatite and BDX were applied accordingly. Computed tomographic (CT) images and panoramic radiographs were obtained immediately after operation and four months later. CT images were reconstructed in three dimensions to measure volumetric changes, and linear measurements were made on panoramic images. The mean (SD) absorption rates for BMP-2/hydroxyapatite and BDX were 13.2 (8.8)% and 13.8 (20.5)%, respectively. While the mean value did not differ significantly between the two materials, the SD was higher in the BDX group than in the BMP-2/hydroxyapatite group. No clinically important complications occurred in either group. We conclude that both BMP-2/hydroxyapatite and BDX were effective in augmenting the alveolar ridge, but BMP-2/hydroxyapatite seemed to be more useful in complicated bone defects.

Original languageEnglish
Pages (from-to)822-829
Number of pages8
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume55
Issue number8
DOIs
Publication statusPublished - 2017 Oct

Bibliographical note

Funding Information:
This work was supported by the Korea Health Industry Development Institute (KHIDI) (grant numbers 2015-31-0005 ); and the Korea Health technology R&D Project through KHIDI, funded by the Ministry of Health & Welfare, Republic of Korea (grant numbers HI15C0904 ).

Publisher Copyright:
© 2017 The British Association of Oral and Maxillofacial Surgeons

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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