Estudio aleatorizado de comparación de la cobertura de los struts de los stents tras la intervención coronaria percutánea guiada por angiografía y la guiada por tomografía de coherencia óptica

Translated title of the contribution: Randomized comparison of stent strut coverage following angiography- or optical coherence tomography-guided percutaneous coronary intervention

Jung Sun Kim, Dong Ho Shin, Byeong Keuk Kim, Young Guk Ko, Donghoon Choi, Yangsoo Jang, Myeongki Hong

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Introduction and objectives The clinical benefits of optical coherence tomography-guided percutaneous coronary intervention are unclear. Therefore, in this study we sought to evaluate the impact of optical coherence tomography guidance on stent strut coverage following drug-eluting stent implantation. Methods A total of 101 patients in 105 lesions were randomly assigned to receive percutaneous coronary intervention under either optical coherence tomography guidance (n = 51 lesions of 50 patients) or angiography guidance (n = 54 lesions of 51 patients), and underwent a follow-up optical coherence tomography examination 6 months after zotarolimus-eluting stent implantation. The primary and secondary end points were the percentage of uncovered and malapposed struts, respectively, on 6-month follow-up optical coherence tomography. Results The percentage of uncovered struts was significantly lower in the optical coherence tomography-guided arm (1.60% [1.84]%, [median, 1.06%] vs 4.51% [5.43]% [median, 2.38%]; P =.0004) at 6-month follow-up. The incidence of stents with ≥ 5.9% uncovered struts was also significantly lower in the optical coherence tomography-guided arm (2 patients [3.9%] vs 14 patients [25.9%]; P =.002). In addition, the percentage of malapposed struts was significantly lower in the optical coherence tomography-guided arm (0.19% [0.51]% [median, 0.0%] vs 0.98% [2.53]% [median, 0.0%]; P =.027). Conclusions Optical coherence tomography-guided percutaneous coronary intervention significantly reduced the incidence of uncovered stent struts at 6 months compared to angiography-guided percutaneous coronary intervention. These findings suggest that optical coherence tomography-guided percutaneous coronary intervention has a beneficial effect on drug-eluting stent strut coverage. Full English text available from: www.revespcardiol.org/en

Original languageSpanish
Pages (from-to)190-197
Number of pages8
JournalRevista Espanola de Cardiologia
Volume68
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1

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Optical Coherence Tomography
Percutaneous Coronary Intervention
Stents
Angiography
Drug-Eluting Stents
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{d1f4d8ad536f47c68485c9ed6cf23f8b,
title = "Estudio aleatorizado de comparaci{\'o}n de la cobertura de los struts de los stents tras la intervenci{\'o}n coronaria percut{\'a}nea guiada por angiograf{\'i}a y la guiada por tomograf{\'i}a de coherencia {\'o}ptica",
abstract = "Introduction and objectives The clinical benefits of optical coherence tomography-guided percutaneous coronary intervention are unclear. Therefore, in this study we sought to evaluate the impact of optical coherence tomography guidance on stent strut coverage following drug-eluting stent implantation. Methods A total of 101 patients in 105 lesions were randomly assigned to receive percutaneous coronary intervention under either optical coherence tomography guidance (n = 51 lesions of 50 patients) or angiography guidance (n = 54 lesions of 51 patients), and underwent a follow-up optical coherence tomography examination 6 months after zotarolimus-eluting stent implantation. The primary and secondary end points were the percentage of uncovered and malapposed struts, respectively, on 6-month follow-up optical coherence tomography. Results The percentage of uncovered struts was significantly lower in the optical coherence tomography-guided arm (1.60{\%} [1.84]{\%}, [median, 1.06{\%}] vs 4.51{\%} [5.43]{\%} [median, 2.38{\%}]; P =.0004) at 6-month follow-up. The incidence of stents with ≥ 5.9{\%} uncovered struts was also significantly lower in the optical coherence tomography-guided arm (2 patients [3.9{\%}] vs 14 patients [25.9{\%}]; P =.002). In addition, the percentage of malapposed struts was significantly lower in the optical coherence tomography-guided arm (0.19{\%} [0.51]{\%} [median, 0.0{\%}] vs 0.98{\%} [2.53]{\%} [median, 0.0{\%}]; P =.027). Conclusions Optical coherence tomography-guided percutaneous coronary intervention significantly reduced the incidence of uncovered stent struts at 6 months compared to angiography-guided percutaneous coronary intervention. These findings suggest that optical coherence tomography-guided percutaneous coronary intervention has a beneficial effect on drug-eluting stent strut coverage. Full English text available from: www.revespcardiol.org/en",
author = "Kim, {Jung Sun} and Shin, {Dong Ho} and Kim, {Byeong Keuk} and Ko, {Young Guk} and Donghoon Choi and Yangsoo Jang and Myeongki Hong",
year = "2015",
month = "3",
day = "1",
doi = "10.1016/j.recesp.2014.07.026",
language = "Spanish",
volume = "68",
pages = "190--197",
journal = "Revista Espanola de Cardiologia",
issn = "0300-8932",
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T1 - Estudio aleatorizado de comparación de la cobertura de los struts de los stents tras la intervención coronaria percutánea guiada por angiografía y la guiada por tomografía de coherencia óptica

AU - Kim, Jung Sun

AU - Shin, Dong Ho

AU - Kim, Byeong Keuk

AU - Ko, Young Guk

AU - Choi, Donghoon

AU - Jang, Yangsoo

AU - Hong, Myeongki

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Introduction and objectives The clinical benefits of optical coherence tomography-guided percutaneous coronary intervention are unclear. Therefore, in this study we sought to evaluate the impact of optical coherence tomography guidance on stent strut coverage following drug-eluting stent implantation. Methods A total of 101 patients in 105 lesions were randomly assigned to receive percutaneous coronary intervention under either optical coherence tomography guidance (n = 51 lesions of 50 patients) or angiography guidance (n = 54 lesions of 51 patients), and underwent a follow-up optical coherence tomography examination 6 months after zotarolimus-eluting stent implantation. The primary and secondary end points were the percentage of uncovered and malapposed struts, respectively, on 6-month follow-up optical coherence tomography. Results The percentage of uncovered struts was significantly lower in the optical coherence tomography-guided arm (1.60% [1.84]%, [median, 1.06%] vs 4.51% [5.43]% [median, 2.38%]; P =.0004) at 6-month follow-up. The incidence of stents with ≥ 5.9% uncovered struts was also significantly lower in the optical coherence tomography-guided arm (2 patients [3.9%] vs 14 patients [25.9%]; P =.002). In addition, the percentage of malapposed struts was significantly lower in the optical coherence tomography-guided arm (0.19% [0.51]% [median, 0.0%] vs 0.98% [2.53]% [median, 0.0%]; P =.027). Conclusions Optical coherence tomography-guided percutaneous coronary intervention significantly reduced the incidence of uncovered stent struts at 6 months compared to angiography-guided percutaneous coronary intervention. These findings suggest that optical coherence tomography-guided percutaneous coronary intervention has a beneficial effect on drug-eluting stent strut coverage. Full English text available from: www.revespcardiol.org/en

AB - Introduction and objectives The clinical benefits of optical coherence tomography-guided percutaneous coronary intervention are unclear. Therefore, in this study we sought to evaluate the impact of optical coherence tomography guidance on stent strut coverage following drug-eluting stent implantation. Methods A total of 101 patients in 105 lesions were randomly assigned to receive percutaneous coronary intervention under either optical coherence tomography guidance (n = 51 lesions of 50 patients) or angiography guidance (n = 54 lesions of 51 patients), and underwent a follow-up optical coherence tomography examination 6 months after zotarolimus-eluting stent implantation. The primary and secondary end points were the percentage of uncovered and malapposed struts, respectively, on 6-month follow-up optical coherence tomography. Results The percentage of uncovered struts was significantly lower in the optical coherence tomography-guided arm (1.60% [1.84]%, [median, 1.06%] vs 4.51% [5.43]% [median, 2.38%]; P =.0004) at 6-month follow-up. The incidence of stents with ≥ 5.9% uncovered struts was also significantly lower in the optical coherence tomography-guided arm (2 patients [3.9%] vs 14 patients [25.9%]; P =.002). In addition, the percentage of malapposed struts was significantly lower in the optical coherence tomography-guided arm (0.19% [0.51]% [median, 0.0%] vs 0.98% [2.53]% [median, 0.0%]; P =.027). Conclusions Optical coherence tomography-guided percutaneous coronary intervention significantly reduced the incidence of uncovered stent struts at 6 months compared to angiography-guided percutaneous coronary intervention. These findings suggest that optical coherence tomography-guided percutaneous coronary intervention has a beneficial effect on drug-eluting stent strut coverage. Full English text available from: www.revespcardiol.org/en

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