Randomized, controlled clinical two-centre study using xenogeneic block grafts loaded with recombinant human bone morphogenetic protein-2 or autogenous bone blocks for lateral ridge augmentation

Daniel S. Thoma, Michael Payer, Norbert Jakse, Stefan P. Bienz, Jürg Hüsler, Patrick R. Schmidlin, Ui Won Jung, Christoph H.F. Hämmerle, Ronald E. Jung

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: To test whether or not the use of a xenogeneic block loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2) results in different bone quantity and quality compared to an autogenous bone block. Materials and Methods: Twenty-four patients with insufficient bone volume for implant placement were randomly assigned to two treatment modalities: a xenogeneic bone block loaded with rhBMP-2 (test) and an autogenous bone block (control). The horizontal ridge width was evaluated prior to augmentation, after augmentation and at 4 months. Patient-reported outcome measures (PROMs) were assessed at suture removal and at 4 months. Biopsies were obtained at 4 months and histologically evaluated. Intergroup comparisons were tested by a two-sided Wilcoxon–Mann–Whitney test, intra-group comparisons were performed with Wilcoxon-signed rank test, and all categorical variables were tested with Chi-squared tests. Results: One autogenous bone block failed. This patient was replaced, and in all subsequently treated 24 patients, implant placement was possible 4 months later. The median ridge width increased from 4.0 mm (Q1 = 2.0; Q3 = 4.0) (test) and 2.0 mm (Q1 = 2.0; Q3 = 3.0) (control) to 7.0 mm (Q1 = 6.0; Q3 = 8.0) (test) and 7.0 mm (Q1 = 6.0; Q3 = 8.0) (control) at 4 months (intergroup p >.05). A higher morbidity was reported at the augmented site in the control group during surgery. Sensitivity was more favourable in the test than that in the control group at 4 months. The biopsies revealed more mineralized tissue in the control group (p <.0043). Conclusions: Both treatment modalities were successful in regenerating bone to place dental implants. PROMs did not reveal any significant differences between the groups except for pain during surgery at the recipient site (in favour of the test group). Histologically, a higher amount of mineralized tissue was observed for the control group at 4 months.

Original languageEnglish
Pages (from-to)265-276
Number of pages12
JournalJournal of Clinical Periodontology
Volume45
Issue number2
DOIs
Publication statusPublished - 2018 Feb 1

Fingerprint

Transplants
Bone and Bones
Control Groups
Biopsy
Dental Implants
Nonparametric Statistics
recombinant human bone morphogenetic protein-2
Sutures
Morbidity
Pain
Therapeutics
Patient Reported Outcome Measures

All Science Journal Classification (ASJC) codes

  • Periodontics

Cite this

Thoma, Daniel S. ; Payer, Michael ; Jakse, Norbert ; Bienz, Stefan P. ; Hüsler, Jürg ; Schmidlin, Patrick R. ; Jung, Ui Won ; Hämmerle, Christoph H.F. ; Jung, Ronald E. / Randomized, controlled clinical two-centre study using xenogeneic block grafts loaded with recombinant human bone morphogenetic protein-2 or autogenous bone blocks for lateral ridge augmentation. In: Journal of Clinical Periodontology. 2018 ; Vol. 45, No. 2. pp. 265-276.
@article{553ee923164c464a835c6fb32c9ece64,
title = "Randomized, controlled clinical two-centre study using xenogeneic block grafts loaded with recombinant human bone morphogenetic protein-2 or autogenous bone blocks for lateral ridge augmentation",
abstract = "Objectives: To test whether or not the use of a xenogeneic block loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2) results in different bone quantity and quality compared to an autogenous bone block. Materials and Methods: Twenty-four patients with insufficient bone volume for implant placement were randomly assigned to two treatment modalities: a xenogeneic bone block loaded with rhBMP-2 (test) and an autogenous bone block (control). The horizontal ridge width was evaluated prior to augmentation, after augmentation and at 4 months. Patient-reported outcome measures (PROMs) were assessed at suture removal and at 4 months. Biopsies were obtained at 4 months and histologically evaluated. Intergroup comparisons were tested by a two-sided Wilcoxon–Mann–Whitney test, intra-group comparisons were performed with Wilcoxon-signed rank test, and all categorical variables were tested with Chi-squared tests. Results: One autogenous bone block failed. This patient was replaced, and in all subsequently treated 24 patients, implant placement was possible 4 months later. The median ridge width increased from 4.0 mm (Q1 = 2.0; Q3 = 4.0) (test) and 2.0 mm (Q1 = 2.0; Q3 = 3.0) (control) to 7.0 mm (Q1 = 6.0; Q3 = 8.0) (test) and 7.0 mm (Q1 = 6.0; Q3 = 8.0) (control) at 4 months (intergroup p >.05). A higher morbidity was reported at the augmented site in the control group during surgery. Sensitivity was more favourable in the test than that in the control group at 4 months. The biopsies revealed more mineralized tissue in the control group (p <.0043). Conclusions: Both treatment modalities were successful in regenerating bone to place dental implants. PROMs did not reveal any significant differences between the groups except for pain during surgery at the recipient site (in favour of the test group). Histologically, a higher amount of mineralized tissue was observed for the control group at 4 months.",
author = "Thoma, {Daniel S.} and Michael Payer and Norbert Jakse and Bienz, {Stefan P.} and J{\"u}rg H{\"u}sler and Schmidlin, {Patrick R.} and Jung, {Ui Won} and H{\"a}mmerle, {Christoph H.F.} and Jung, {Ronald E.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1111/jcpe.12841",
language = "English",
volume = "45",
pages = "265--276",
journal = "Journal of Clinical Periodontology",
issn = "0303-6979",
publisher = "Blackwell Munksgaard",
number = "2",

}

Randomized, controlled clinical two-centre study using xenogeneic block grafts loaded with recombinant human bone morphogenetic protein-2 or autogenous bone blocks for lateral ridge augmentation. / Thoma, Daniel S.; Payer, Michael; Jakse, Norbert; Bienz, Stefan P.; Hüsler, Jürg; Schmidlin, Patrick R.; Jung, Ui Won; Hämmerle, Christoph H.F.; Jung, Ronald E.

In: Journal of Clinical Periodontology, Vol. 45, No. 2, 01.02.2018, p. 265-276.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Randomized, controlled clinical two-centre study using xenogeneic block grafts loaded with recombinant human bone morphogenetic protein-2 or autogenous bone blocks for lateral ridge augmentation

AU - Thoma, Daniel S.

AU - Payer, Michael

AU - Jakse, Norbert

AU - Bienz, Stefan P.

AU - Hüsler, Jürg

AU - Schmidlin, Patrick R.

AU - Jung, Ui Won

AU - Hämmerle, Christoph H.F.

AU - Jung, Ronald E.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Objectives: To test whether or not the use of a xenogeneic block loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2) results in different bone quantity and quality compared to an autogenous bone block. Materials and Methods: Twenty-four patients with insufficient bone volume for implant placement were randomly assigned to two treatment modalities: a xenogeneic bone block loaded with rhBMP-2 (test) and an autogenous bone block (control). The horizontal ridge width was evaluated prior to augmentation, after augmentation and at 4 months. Patient-reported outcome measures (PROMs) were assessed at suture removal and at 4 months. Biopsies were obtained at 4 months and histologically evaluated. Intergroup comparisons were tested by a two-sided Wilcoxon–Mann–Whitney test, intra-group comparisons were performed with Wilcoxon-signed rank test, and all categorical variables were tested with Chi-squared tests. Results: One autogenous bone block failed. This patient was replaced, and in all subsequently treated 24 patients, implant placement was possible 4 months later. The median ridge width increased from 4.0 mm (Q1 = 2.0; Q3 = 4.0) (test) and 2.0 mm (Q1 = 2.0; Q3 = 3.0) (control) to 7.0 mm (Q1 = 6.0; Q3 = 8.0) (test) and 7.0 mm (Q1 = 6.0; Q3 = 8.0) (control) at 4 months (intergroup p >.05). A higher morbidity was reported at the augmented site in the control group during surgery. Sensitivity was more favourable in the test than that in the control group at 4 months. The biopsies revealed more mineralized tissue in the control group (p <.0043). Conclusions: Both treatment modalities were successful in regenerating bone to place dental implants. PROMs did not reveal any significant differences between the groups except for pain during surgery at the recipient site (in favour of the test group). Histologically, a higher amount of mineralized tissue was observed for the control group at 4 months.

AB - Objectives: To test whether or not the use of a xenogeneic block loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2) results in different bone quantity and quality compared to an autogenous bone block. Materials and Methods: Twenty-four patients with insufficient bone volume for implant placement were randomly assigned to two treatment modalities: a xenogeneic bone block loaded with rhBMP-2 (test) and an autogenous bone block (control). The horizontal ridge width was evaluated prior to augmentation, after augmentation and at 4 months. Patient-reported outcome measures (PROMs) were assessed at suture removal and at 4 months. Biopsies were obtained at 4 months and histologically evaluated. Intergroup comparisons were tested by a two-sided Wilcoxon–Mann–Whitney test, intra-group comparisons were performed with Wilcoxon-signed rank test, and all categorical variables were tested with Chi-squared tests. Results: One autogenous bone block failed. This patient was replaced, and in all subsequently treated 24 patients, implant placement was possible 4 months later. The median ridge width increased from 4.0 mm (Q1 = 2.0; Q3 = 4.0) (test) and 2.0 mm (Q1 = 2.0; Q3 = 3.0) (control) to 7.0 mm (Q1 = 6.0; Q3 = 8.0) (test) and 7.0 mm (Q1 = 6.0; Q3 = 8.0) (control) at 4 months (intergroup p >.05). A higher morbidity was reported at the augmented site in the control group during surgery. Sensitivity was more favourable in the test than that in the control group at 4 months. The biopsies revealed more mineralized tissue in the control group (p <.0043). Conclusions: Both treatment modalities were successful in regenerating bone to place dental implants. PROMs did not reveal any significant differences between the groups except for pain during surgery at the recipient site (in favour of the test group). Histologically, a higher amount of mineralized tissue was observed for the control group at 4 months.

UR - http://www.scopus.com/inward/record.url?scp=85038026473&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038026473&partnerID=8YFLogxK

U2 - 10.1111/jcpe.12841

DO - 10.1111/jcpe.12841

M3 - Article

C2 - 29150957

AN - SCOPUS:85038026473

VL - 45

SP - 265

EP - 276

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

SN - 0303-6979

IS - 2

ER -