Rapid and repeatable fabrication of high A/R silk fibroin microneedles using thermally-drawn micromolds

Ji Yong Lee, Seung Hyun Park, Il Ho Seo, Kang Ju Lee, Won Hyoung Ryu

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Abstract Thermal drawing is a versatile rapid prototyping method that can freely form microneedle (MN) structures with ultra-high aspect ratio without relying on any complex and expensive process. However, it is still challenging to repeatedly produce MNs with identical shapes using this thermal drawing due to small fluctuations in processing conditions such as temperatures, drawing speeds, drawing heights, or parallelism in the drawing setup. In addition, thermal drawing is only applicable to thermoplastic materials and most natural biomaterials are incompatible with this method. Thus, we propose use of thermal drawing to fabricate master molds with high aspect ratios and replicate the shape by micromolding. In this work, high A/R MNs with various body profiles were fabricated by thermal drawing and replicated to silk fibroin (SF) MNs multiple times using micromolding. The original MN shape was precisely copied to the SF MNs. Methanol treatment enhanced the mechanical strength of SF MNs up to about 113% more depending on the treatment duration. We also demonstrated that methanol exposure time could effectively control drug release rates from SF MNs.

Original languageEnglish
Article number11915
Pages (from-to)11-19
Number of pages9
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume94
DOIs
Publication statusPublished - 2015 May 1

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Fibroins
Silk
Hot Temperature
Methanol
Biocompatible Materials
Temperature

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Pharmaceutical Science

Cite this

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abstract = "Abstract Thermal drawing is a versatile rapid prototyping method that can freely form microneedle (MN) structures with ultra-high aspect ratio without relying on any complex and expensive process. However, it is still challenging to repeatedly produce MNs with identical shapes using this thermal drawing due to small fluctuations in processing conditions such as temperatures, drawing speeds, drawing heights, or parallelism in the drawing setup. In addition, thermal drawing is only applicable to thermoplastic materials and most natural biomaterials are incompatible with this method. Thus, we propose use of thermal drawing to fabricate master molds with high aspect ratios and replicate the shape by micromolding. In this work, high A/R MNs with various body profiles were fabricated by thermal drawing and replicated to silk fibroin (SF) MNs multiple times using micromolding. The original MN shape was precisely copied to the SF MNs. Methanol treatment enhanced the mechanical strength of SF MNs up to about 113{\%} more depending on the treatment duration. We also demonstrated that methanol exposure time could effectively control drug release rates from SF MNs.",
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Rapid and repeatable fabrication of high A/R silk fibroin microneedles using thermally-drawn micromolds. / Lee, Ji Yong; Park, Seung Hyun; Seo, Il Ho; Lee, Kang Ju; Ryu, Won Hyoung.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 94, 11915, 01.05.2015, p. 11-19.

Research output: Contribution to journalArticle

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