Rapid and sustained cognitive recovery in APP/PS1 transgenic mice by co-administration of EPPS and donepezil

Hye Yun Kim, Hyunjin Vincent Kim, Dongkeun K. Lee, Seung Hoon Yang, YoungSoo Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease characterized by sequential progression of pathological events, such as aggregation of amyloid-β proteins, followed by outward symptoms of cognitive impairments. Given that a combination of different therapeutic strategies often provides more rapid and effective outcomes in diverse areas of clinical treatment, we hypothesized that administration of anti-amyloid drugs with cognitive enhancers would result in synergistic effects in AD treatment. Here, we co-administered 4-(2-hydroxyethyl)-1-piperazinepropane-sulphonic acid (EPPS), an amyloid-clearing chemical, and donepezil, an acetylcholinesterase inhibitor, to determine whether they could serve complementary roles for each other in regards to AD treatment. We found that oral administration of these two molecules led to a rapid and consistent cognitive improvement in APP/PS1 transgenic mice. Although there was no evidence for synergistic effects, our results indicated that EPPS and donepezil function complementary to each other without altering their individual effects. Thus, the combined use of disease-modifying and symptomatic relief drugs may be a promising approach in the treatment of AD.

Original languageEnglish
Article number34165
JournalScientific reports
Volume6
DOIs
Publication statusPublished - 2016 Oct 31

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Sulfonic Acids
Transgenic Mice
Alzheimer Disease
Amyloid
Nootropic Agents
Amyloidogenic Proteins
Therapeutics
Cholinesterase Inhibitors
Neurodegenerative Diseases
Pharmaceutical Preparations
Oral Administration
donepezil

All Science Journal Classification (ASJC) codes

  • General

Cite this

Kim, Hye Yun ; Kim, Hyunjin Vincent ; Lee, Dongkeun K. ; Yang, Seung Hoon ; Kim, YoungSoo. / Rapid and sustained cognitive recovery in APP/PS1 transgenic mice by co-administration of EPPS and donepezil. In: Scientific reports. 2016 ; Vol. 6.
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Rapid and sustained cognitive recovery in APP/PS1 transgenic mice by co-administration of EPPS and donepezil. / Kim, Hye Yun; Kim, Hyunjin Vincent; Lee, Dongkeun K.; Yang, Seung Hoon; Kim, YoungSoo.

In: Scientific reports, Vol. 6, 34165, 31.10.2016.

Research output: Contribution to journalArticle

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