Rapid identification of thrombocytopenia-associated multiple organ failure using red blood cell parameters and a volume/hemoglobin concentration cytogram

Jong Ha Yoo, Jongwook Lee, Kyoung Ho Roh, Hyun Ok Kim, Jae Woo Song, Jong Rak Choi, YoungKeun Kim, Kyunga Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Thrombocytopenia-associated multiple organ failure (TAMOF) has a high mortality rate when not treated, and early detection of TAMOF is very important diagnostically and therapeutically. We describe herein our experience of early detection of TAMOF, using an automated hematology analyzer. From 498,390 inpatients, we selected 12 patients suspected of having peripheral schistocytosis, based on the results of red blood cell (RBC) parameters and a volume/hemoglobin concentration (V/HC) cytogram. We promptly evaluated whether the individual patients had clinical manifestations and laboratory findings were consistent with TAMOF. Plasma exchanges were then performed for each patient. All 12 patients had TAMOF. The mean values of RBC parameters were significantly higher in all of the patients than with the reference range, however, 3 patients had % RBC fragments within the reference range. The mean value of ADAMTS-13 activity was slightly lower in patients compared with the reference range. Of the 12 patients, remission was obtained in 9 patients (75%) within 4 to 5 weeks using plasma exchanges. Three patients died. An increased percentage of microcytic hyperchromic cells with anisocytosis and anisochromia indicated the presence of schistocytes, making it an excellent screening marker for TAMOF. Identification of TAMOF with RBC parameters and a V/HC cytogram is a facile and rapid method along with an automated hematology analyzer already in use for routine complete blood cell counting test.

Original languageEnglish
Pages (from-to)845-850
Number of pages6
JournalYonsei medical journal
Volume52
Issue number5
DOIs
Publication statusPublished - 2011 Sep 1

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Multiple Organ Failure
Thrombocytopenia
Hemoglobins
Erythrocytes
Reference Values
Plasma Exchange
Hematology
Inpatients
Blood Cells

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Yoo, Jong Ha ; Lee, Jongwook ; Roh, Kyoung Ho ; Kim, Hyun Ok ; Song, Jae Woo ; Choi, Jong Rak ; Kim, YoungKeun ; Lee, Kyunga. / Rapid identification of thrombocytopenia-associated multiple organ failure using red blood cell parameters and a volume/hemoglobin concentration cytogram. In: Yonsei medical journal. 2011 ; Vol. 52, No. 5. pp. 845-850.
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Rapid identification of thrombocytopenia-associated multiple organ failure using red blood cell parameters and a volume/hemoglobin concentration cytogram. / Yoo, Jong Ha; Lee, Jongwook; Roh, Kyoung Ho; Kim, Hyun Ok; Song, Jae Woo; Choi, Jong Rak; Kim, YoungKeun; Lee, Kyunga.

In: Yonsei medical journal, Vol. 52, No. 5, 01.09.2011, p. 845-850.

Research output: Contribution to journalArticle

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