Rapid recovery of tissue hypoxia by cotransplantation of endothelial cells

Jinsoo Oh, Keung Nyun Kim, Do Heum Yoon, Seong Rok Han, Dong Ah Shin, Yoon Ha

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Disruption of blood vessels caused by a spinal cord injury leads to tissue hypoxia. This hypoxic condition reduces the survival of transplanted stem cells, consequentially decreasing the effectiveness of stem cell therapy. In this study, we investigated the correlation between angiogenesis and the survival of transplanted neural stem cells in a spinal cord injury model. Hypoxia-specific luciferase-expressing neural stem cells (EpoSV-Luc NSC) were used as a tool for the detection of hypoxia caused by a spinal cord injury. In vivo, angiogenesis by cotransplantation of endothelial cells quickly recovered tissue hypoxia caused by a spinal cord injury. As a result, cotransplantation of endothelial cells improved the survival of neural stem cells transplanted into the injured spinal cord.

Original languageEnglish
Pages (from-to)658-662
Number of pages5
JournalNeuroReport
Volume23
Issue number11
DOIs
Publication statusPublished - 2012 Aug 1

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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