Rare β-Resorcylic Acid Derivatives from a Halophyte-Associated Fungus Colletotrichum gloeosporioides JS0419 and Their Antifungal Activities

Sunghee Bang, Jaekyeong Kim, Jiwon Oh, Ji Seok Kim, Seong Ryong Yu, Stephen T. Deyrup, Yong Sun Bahn, Sang Hee Shim

Research output: Contribution to journalArticlepeer-review

Abstract

Six new β-resorcylic acid derivatives (1–5 and 7) were isolated from a halophyte-associated fungus, Colletotrichum gloeosporioides JS0419, together with four previously reported β-resorcylic acid lactones (RALs). The relative and absolute stereochemistry of 1 was completely established by a combination of spectroscopic data and chemical reactions. The structures of the isolated compounds were elucidated by analysis of HRMS and NMR data. Notably, compounds 1–3 had a β-resorcylic acid harboring a long unesterified aliphatic side chain, whereas the long aliphatic chains were esterified to form macrolactones in 4–9. Among the isolated compounds, monocillin I and radicicol showed potent antifungal activities against Cryptococcus neoformans, comparable to clini-cally available antifungal agents and radicicol showed weak antifungal activity against Candida al-bicans. These findings provide insight into the chemical diversity of fungal RAL-type compounds and their pharmacological potential.

Original languageEnglish
Article number195
JournalMarine Drugs
Volume20
Issue number3
DOIs
Publication statusPublished - 2022 Mar

Bibliographical note

Funding Information:
Funding: This research was supported by the National Research Foundation of Korea (NRF-2021R1A2C1004958).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Drug Discovery

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