We synthesized a novel receptor with a unique combination of sp2 nitrogen (-CH=N-) and carbonyl groups from amide linkages. These two moieties are judiciously incorporated into the receptor design such that these sites simultaneous binding a metal ion may generate a stable five-member ring. The receptor has been used to selectively detect Zn2+ through changes in the fluorescence spectra. Upon Zn2+ binding with the receptor, the fluorescence band shifted to enhance fluorescence intensity, allowing ratiometric determination of Zn2+ concentration.
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation (NRF) grant funded by the Korea government (MEST) through the Center for Bioactive Molecular Hybrids (No. R11-2003-019-00000-0 ).
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry