Rationale for radiotherapy as a treatment modality in gastric mucosa-associated lymphoid tissue lymphoma

Won Park, Sei Kyung Chang, Woo Ick Yang, Young Hyeh Ko, Seung Jae Huh, Yong Chan Ahn, Chang-Ok Suh

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose To provide a rationale for the use of local radiotherapy (RT) for the treatment of low-grade mucosa-associated lymphoid tissue lymphoma of the stomach (MLS). In addition, the clinicopathologic characteristics were analyzed. Methods and materials The data of 72 patients with MLS, who underwent radical surgery between 1991 and 2001, were retrospectively reviewed. The depth of invasion into the gastric wall and the pattern of lymph node spread according to pathologic grade were analyzed. Results The patient age range was 24-77 years (median, 51 years). Of the 72 patients, 45 (62.5%) had low-grade and 27 (37.5%) had high-grade MLS; 44 (61%) had Stage I and 28 (39%) Stage II. The tumors were confined to the mucosa or submucosa in 43 patients (58.9%). Sixty-seven percent of low-grade tumors and 48% of high-grade tumors were confined to the mucosa and submucosa. Lymph node involvement was identified in 24.4% of the low-grade MLS patients and 63.0% of the high-grade MLS patients. In the low-grade group, lymph node involvement was limited to the perigastric lymph nodes in all cases except for one. One patient with tumor infiltration beyond the serosa had extensive lymph node involvement into the paraaortic and omental lymph nodes. Conclusion Local RT to the stomach and regional lymphatics can be applied preferably instead of gastrectomy in patients with low-grade MLS who are negative for Helicobacter pylori or are refractory to anti-H. pylori therapy. The timing of RT and the exclusion criteria for RT should be determined in the future.

Original languageEnglish
Pages (from-to)1480-1486
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume58
Issue number5
DOIs
Publication statusPublished - 2004 Apr 1

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Marginal Zone B-Cell Lymphoma
Gastric Mucosa
radiation therapy
grade
Radiotherapy
lymphatic system
Lymph Nodes
tumors
Stomach
Therapeutics
stomach
Helicobacter pylori
Neoplasms
Mucous Membrane
Serous Membrane
Gastrectomy
Non-Hodgkin's Lymphoma
refractories
infiltration
exclusion

All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Park, Won ; Chang, Sei Kyung ; Yang, Woo Ick ; Ko, Young Hyeh ; Huh, Seung Jae ; Ahn, Yong Chan ; Suh, Chang-Ok. / Rationale for radiotherapy as a treatment modality in gastric mucosa-associated lymphoid tissue lymphoma. In: International Journal of Radiation Oncology Biology Physics. 2004 ; Vol. 58, No. 5. pp. 1480-1486.
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abstract = "Purpose To provide a rationale for the use of local radiotherapy (RT) for the treatment of low-grade mucosa-associated lymphoid tissue lymphoma of the stomach (MLS). In addition, the clinicopathologic characteristics were analyzed. Methods and materials The data of 72 patients with MLS, who underwent radical surgery between 1991 and 2001, were retrospectively reviewed. The depth of invasion into the gastric wall and the pattern of lymph node spread according to pathologic grade were analyzed. Results The patient age range was 24-77 years (median, 51 years). Of the 72 patients, 45 (62.5{\%}) had low-grade and 27 (37.5{\%}) had high-grade MLS; 44 (61{\%}) had Stage I and 28 (39{\%}) Stage II. The tumors were confined to the mucosa or submucosa in 43 patients (58.9{\%}). Sixty-seven percent of low-grade tumors and 48{\%} of high-grade tumors were confined to the mucosa and submucosa. Lymph node involvement was identified in 24.4{\%} of the low-grade MLS patients and 63.0{\%} of the high-grade MLS patients. In the low-grade group, lymph node involvement was limited to the perigastric lymph nodes in all cases except for one. One patient with tumor infiltration beyond the serosa had extensive lymph node involvement into the paraaortic and omental lymph nodes. Conclusion Local RT to the stomach and regional lymphatics can be applied preferably instead of gastrectomy in patients with low-grade MLS who are negative for Helicobacter pylori or are refractory to anti-H. pylori therapy. The timing of RT and the exclusion criteria for RT should be determined in the future.",
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Rationale for radiotherapy as a treatment modality in gastric mucosa-associated lymphoid tissue lymphoma. / Park, Won; Chang, Sei Kyung; Yang, Woo Ick; Ko, Young Hyeh; Huh, Seung Jae; Ahn, Yong Chan; Suh, Chang-Ok.

In: International Journal of Radiation Oncology Biology Physics, Vol. 58, No. 5, 01.04.2004, p. 1480-1486.

Research output: Contribution to journalArticle

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AU - Park, Won

AU - Chang, Sei Kyung

AU - Yang, Woo Ick

AU - Ko, Young Hyeh

AU - Huh, Seung Jae

AU - Ahn, Yong Chan

AU - Suh, Chang-Ok

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N2 - Purpose To provide a rationale for the use of local radiotherapy (RT) for the treatment of low-grade mucosa-associated lymphoid tissue lymphoma of the stomach (MLS). In addition, the clinicopathologic characteristics were analyzed. Methods and materials The data of 72 patients with MLS, who underwent radical surgery between 1991 and 2001, were retrospectively reviewed. The depth of invasion into the gastric wall and the pattern of lymph node spread according to pathologic grade were analyzed. Results The patient age range was 24-77 years (median, 51 years). Of the 72 patients, 45 (62.5%) had low-grade and 27 (37.5%) had high-grade MLS; 44 (61%) had Stage I and 28 (39%) Stage II. The tumors were confined to the mucosa or submucosa in 43 patients (58.9%). Sixty-seven percent of low-grade tumors and 48% of high-grade tumors were confined to the mucosa and submucosa. Lymph node involvement was identified in 24.4% of the low-grade MLS patients and 63.0% of the high-grade MLS patients. In the low-grade group, lymph node involvement was limited to the perigastric lymph nodes in all cases except for one. One patient with tumor infiltration beyond the serosa had extensive lymph node involvement into the paraaortic and omental lymph nodes. Conclusion Local RT to the stomach and regional lymphatics can be applied preferably instead of gastrectomy in patients with low-grade MLS who are negative for Helicobacter pylori or are refractory to anti-H. pylori therapy. The timing of RT and the exclusion criteria for RT should be determined in the future.

AB - Purpose To provide a rationale for the use of local radiotherapy (RT) for the treatment of low-grade mucosa-associated lymphoid tissue lymphoma of the stomach (MLS). In addition, the clinicopathologic characteristics were analyzed. Methods and materials The data of 72 patients with MLS, who underwent radical surgery between 1991 and 2001, were retrospectively reviewed. The depth of invasion into the gastric wall and the pattern of lymph node spread according to pathologic grade were analyzed. Results The patient age range was 24-77 years (median, 51 years). Of the 72 patients, 45 (62.5%) had low-grade and 27 (37.5%) had high-grade MLS; 44 (61%) had Stage I and 28 (39%) Stage II. The tumors were confined to the mucosa or submucosa in 43 patients (58.9%). Sixty-seven percent of low-grade tumors and 48% of high-grade tumors were confined to the mucosa and submucosa. Lymph node involvement was identified in 24.4% of the low-grade MLS patients and 63.0% of the high-grade MLS patients. In the low-grade group, lymph node involvement was limited to the perigastric lymph nodes in all cases except for one. One patient with tumor infiltration beyond the serosa had extensive lymph node involvement into the paraaortic and omental lymph nodes. Conclusion Local RT to the stomach and regional lymphatics can be applied preferably instead of gastrectomy in patients with low-grade MLS who are negative for Helicobacter pylori or are refractory to anti-H. pylori therapy. The timing of RT and the exclusion criteria for RT should be determined in the future.

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