Real-time monitoring of cancer cells in live mouse bone marrow

Sung Hwan Lee, Sang A. Park, Yunyun Zou, Sang Uk Seo, Chang Duk Jun, Woo Jung Lee, Young Min Hyun, Namhoon Cho

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Disseminated tumor cells in the bone marrow environment are the main cause of systemic metastasis after curative treatment for major solid tumors. However, the detailed biological processes of tumor biology in bone marrow have not been well defined in a real-time manner, because of a lack of a proper in vivo experimental model thereof. In this study, we established intravital imaging models of the bone marrow environment to enable real-time observation of cancer cells in the bone marrow. Using these novel imaging models of intact bone marrow and transplanted bone marrow of mice, respectively, via two-photon microscopy, we could first successfully track and analyze both the distribution and the phenotype of cancer cells in bone marrow of live mouse. Therefore, these novel in vivo imaging models for the bone marrow would provide a valuable tool to identify the biologic processes of cancer cells in a real-time manner in a live animal model.

Original languageEnglish
Article number1681
JournalFrontiers in Immunology
Volume9
Issue numberAUG
DOIs
Publication statusPublished - 2018 Aug 2

Fingerprint

Bone Marrow
Bone Marrow Cells
Neoplasms
Biological Phenomena
Photons
Microscopy
Theoretical Models
Animal Models
Observation
Neoplasm Metastasis
Phenotype

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Lee, S. H., Park, S. A., Zou, Y., Seo, S. U., Jun, C. D., Lee, W. J., ... Cho, N. (2018). Real-time monitoring of cancer cells in live mouse bone marrow. Frontiers in Immunology, 9(AUG), [1681]. https://doi.org/10.3389/fimmu.2018.01681
Lee, Sung Hwan ; Park, Sang A. ; Zou, Yunyun ; Seo, Sang Uk ; Jun, Chang Duk ; Lee, Woo Jung ; Hyun, Young Min ; Cho, Namhoon. / Real-time monitoring of cancer cells in live mouse bone marrow. In: Frontiers in Immunology. 2018 ; Vol. 9, No. AUG.
@article{b8029dc4bf6748fb865f7e87ca82ec7a,
title = "Real-time monitoring of cancer cells in live mouse bone marrow",
abstract = "Disseminated tumor cells in the bone marrow environment are the main cause of systemic metastasis after curative treatment for major solid tumors. However, the detailed biological processes of tumor biology in bone marrow have not been well defined in a real-time manner, because of a lack of a proper in vivo experimental model thereof. In this study, we established intravital imaging models of the bone marrow environment to enable real-time observation of cancer cells in the bone marrow. Using these novel imaging models of intact bone marrow and transplanted bone marrow of mice, respectively, via two-photon microscopy, we could first successfully track and analyze both the distribution and the phenotype of cancer cells in bone marrow of live mouse. Therefore, these novel in vivo imaging models for the bone marrow would provide a valuable tool to identify the biologic processes of cancer cells in a real-time manner in a live animal model.",
author = "Lee, {Sung Hwan} and Park, {Sang A.} and Yunyun Zou and Seo, {Sang Uk} and Jun, {Chang Duk} and Lee, {Woo Jung} and Hyun, {Young Min} and Namhoon Cho",
year = "2018",
month = "8",
day = "2",
doi = "10.3389/fimmu.2018.01681",
language = "English",
volume = "9",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S. A.",
number = "AUG",

}

Lee, SH, Park, SA, Zou, Y, Seo, SU, Jun, CD, Lee, WJ, Hyun, YM & Cho, N 2018, 'Real-time monitoring of cancer cells in live mouse bone marrow', Frontiers in Immunology, vol. 9, no. AUG, 1681. https://doi.org/10.3389/fimmu.2018.01681

Real-time monitoring of cancer cells in live mouse bone marrow. / Lee, Sung Hwan; Park, Sang A.; Zou, Yunyun; Seo, Sang Uk; Jun, Chang Duk; Lee, Woo Jung; Hyun, Young Min; Cho, Namhoon.

In: Frontiers in Immunology, Vol. 9, No. AUG, 1681, 02.08.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Real-time monitoring of cancer cells in live mouse bone marrow

AU - Lee, Sung Hwan

AU - Park, Sang A.

AU - Zou, Yunyun

AU - Seo, Sang Uk

AU - Jun, Chang Duk

AU - Lee, Woo Jung

AU - Hyun, Young Min

AU - Cho, Namhoon

PY - 2018/8/2

Y1 - 2018/8/2

N2 - Disseminated tumor cells in the bone marrow environment are the main cause of systemic metastasis after curative treatment for major solid tumors. However, the detailed biological processes of tumor biology in bone marrow have not been well defined in a real-time manner, because of a lack of a proper in vivo experimental model thereof. In this study, we established intravital imaging models of the bone marrow environment to enable real-time observation of cancer cells in the bone marrow. Using these novel imaging models of intact bone marrow and transplanted bone marrow of mice, respectively, via two-photon microscopy, we could first successfully track and analyze both the distribution and the phenotype of cancer cells in bone marrow of live mouse. Therefore, these novel in vivo imaging models for the bone marrow would provide a valuable tool to identify the biologic processes of cancer cells in a real-time manner in a live animal model.

AB - Disseminated tumor cells in the bone marrow environment are the main cause of systemic metastasis after curative treatment for major solid tumors. However, the detailed biological processes of tumor biology in bone marrow have not been well defined in a real-time manner, because of a lack of a proper in vivo experimental model thereof. In this study, we established intravital imaging models of the bone marrow environment to enable real-time observation of cancer cells in the bone marrow. Using these novel imaging models of intact bone marrow and transplanted bone marrow of mice, respectively, via two-photon microscopy, we could first successfully track and analyze both the distribution and the phenotype of cancer cells in bone marrow of live mouse. Therefore, these novel in vivo imaging models for the bone marrow would provide a valuable tool to identify the biologic processes of cancer cells in a real-time manner in a live animal model.

UR - http://www.scopus.com/inward/record.url?scp=85051102563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051102563&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2018.01681

DO - 10.3389/fimmu.2018.01681

M3 - Article

C2 - 30116236

AN - SCOPUS:85051102563

VL - 9

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

IS - AUG

M1 - 1681

ER -