Recent advances in cytochrome bc 1: Inter monomer electronic communication?

Bahia Khalfaoui-Hassani, Pascal Lanciano, Dong Woo Lee, Elisabeth Darrouzet, Fevzi Daldal

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

The ubihydroquinone: cytochrome c oxidoreductase, or cytochrome bc 1, is a central component of photosynthetic and respiratory energy transduction pathways in many organisms. It contributes to the generation of membrane potential and proton gradient used for cellular energy production (ATP). The three-dimensional structures of cytochrome bc 1 indicate that its two monomers are intertwined to form a symmetrical homodimer. This unusual architecture raises the issue of whether the monomers operate independently, or function cooperatively during the catalytic cycle of the enzyme. In this review, recent progresses achieved in our understanding of the mechanism of function of dimeric cytochrome bc 1 are presented. New genetic approaches producing heterodimeric enzymes, and emerging insights related to the inter monomer electron transfer between the heme b cofactors of cytochrome bc 1 are described.

Original languageEnglish
Pages (from-to)617-621
Number of pages5
JournalFEBS Letters
Volume586
Issue number5
DOIs
Publication statusPublished - 2012 Mar 9

Bibliographical note

Funding Information:
This work was supported by grants from NIH ( GM 38237 ) and DOE ( 91ER 20052 ) to F.D.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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