Recent advances in extracellular vesicle-based organic nanotherapeutic drugs for precision cancer therapy

Van Nghia Nguyen, Thuy Nguyen Thi Dao, Moonyeon Cho, Hyunsun Jeong, Minh Tri Nguyen-Le, Yong Shin, Juyoung Yoon

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Due to the critical limitations of conventional antitumor agents, great efforts have been made to develop advanced drug delivery systems to enhance the therapeutic outcomes of antitumor drugs, reduce side effects, and overcome tumor drug resistance. In recent years, extracellular vesicles, especially exosomes, which are membrane-bound extracellular vesicles endogenously secreted by many types of human cells, have garnered increasing attention in biomedical applications. In particular, they are considered highly promising natural delivery nanocarriers for cancer therapy owing to their unique features, including nanoscale bilayer membrane, natural cell-to-cell communication, excellent biocompatibility, low toxicity and immunogenicity, prolonged circulation half-life, and good structural stability. This review provides essential knowledge of extracellular vesicles and highlights exosomes, small extracellular vesicles, as potential nanocarriers for drug delivery. In addition, recent developments of exosome-based organic nanotherapeutic agents for cancer treatment, mainly including chemotherapy, cancer phototherapy, and cancer sonodynamic therapy, are introduced. Finally, challenges and prospects are comprehensively discussed to provide further guidance for the future development of exosomal drug delivery systems. We believe that this review will spur the transition of exosome-based nanotherapeutic agents from bench to bedside for cancer therapeutics.

Original languageEnglish
Article number215006
JournalCoordination Chemistry Reviews
Publication statusPublished - 2023 Mar 15

Bibliographical note

Funding Information:
This research was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2022R1A2C3005420 for J. Y., No. 2020R1A2C2007148 for Y. Shin). This research was also supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(2022R1I1A1A01055905).

Publisher Copyright:
© 2022 Elsevier B.V.

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry


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