Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis

Jun Chen, Xixi Zhang, Reid Millican, Jennifer Sherwood, Sean Martin, Hanjoong Jo, Young sup Yoon, Brigitta C. Brott, Ho Wook Jun

Research output: Contribution to journalReview articlepeer-review

Abstract

Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in arteries, leading to narrowing and thrombosis. It affects the heart, brain, and peripheral vessels and is the leading cause of mortality in the United States. Researchers have strived to design nanomaterials of various functions, ranging from non-invasive imaging contrast agents, targeted therapeutic delivery systems to multifunctional nanoagents able to target, diagnose, and treat atherosclerosis. Therefore, this review aims to summarize recent progress (2017-now) in the development of nanomaterials and their applications to improve atherosclerosis diagnosis and therapy during the preclinical and clinical stages of the disease.

Original languageEnglish
Pages (from-to)142-199
Number of pages58
JournalAdvanced Drug Delivery Reviews
Volume170
DOIs
Publication statusPublished - 2021 Mar

Bibliographical note

Publisher Copyright:
© 2021 Elsevier B.V.

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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