Recent biotechnological developments in reshaping the microalgal genome: A signal for green recovery in biorefinery practices

Meenakshi Singh, Navonil Mal, Reecha Mohapatra, Trisha Bagchi, Sreestha Dinesh Parambath, Murthy Chavali, Kummara Madhusudana Rao, S. V. Ramanaiah, Abudukeremu Kadier, Gopalakrishnan Kumar, K. Chandrasekhar, Sang Hyoun Kim

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The use of renewable energy sources as a substitute for nonrenewable fossil fuels is urgently required. Algae biorefinery platform provides an excellent alternate to overcome future energy problems. However, to let this viable biomass be competent with existing feedstocks, it is necessary to exploit genetic manipulation and improvement in upstream and downstream platforms for optimal bio-product recovery. Furthermore, the techno-economic strategies further maximize metabolites production for biofuel, biohydrogen, and other industrial applications. The experimental methodologies in algal photobioreactor promote high biomass production, enriched in lipid and starch content in limited environmental conditions. This review presents an optimization framework combining genetic manipulation methods to simulate microalgal growth dynamics, understand the complexity of algal biorefinery to scale up, and identify green strategies for techno-economic feasibility of algae for biomass conversion. Overall, the algal biorefinery opens up new possibilities for the valorization of algae biomass and the synthesis of various novel products.

Original languageEnglish
Article number133513
Publication statusPublished - 2022 Apr

Bibliographical note

Funding Information:
The research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government ( Ministry of Science & ICT ) (No. NRF- 2020R1A2B5B02001757 ).

Publisher Copyright:
© 2022 Elsevier Ltd

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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