Recent changes in the clinicopathologic features of Korean men with prostate cancer: A comparison with Western populations

Seok Soo Byun, Sangchul Lee, Sang Eun Lee, Eunsik Lee, Seong Il Seo, Hyun Moo Lee, Han Yong Choi, Cheryn Song, Hanjong Ahn, Young Deuk Choi, Jin Seon Cho

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18 Citations (Scopus)

Abstract

Purpose: The aim of this study was to evaluate the recent changes in the clinicopathologic features of prostate cancer in Korea and to compare these features with those of Western populations. Materials and Methods: We retrospectively reviewed the data of 1582 men undergoing radical prostatectomy for clinically localized prostate cancer between 1995 and 2007 at 10 institutions in Korea for comparison with Western studies. The patients were divided into two groups in order to evaluate the recent clinicopathological changes in prostate cancer: Group 1 had surgery between 1995 and 2003 (n=280) and Group 2 had surgery between 2004 and 2007 (n=1302). The mean follow-up period was 24 months. Results: Group 1 had a higher prostate-specific antigen level than Group 2 (10.0 ng/mL vs. 7.5 ng/mL, respectively; p<0.001) and a lower proportion of biopsy Gleason scores ≤6 (35.0% vs. 48.1%, respectively; p<0.001). The proportion of patients with clinical T1 stage was higher in Group 2 than in Group 1. Group 1 had a lower proportion of organ-confined disease (59.6% vs. 68.6%; p<0.001) and a lower proportion of Gleason scores ≤6 (21.3% vs. 33.0%; p<0.001), compared to Group 2. However, the relatively higher proportion of pathologic Gleason scores ≤6 in Group 2 was still lower than those of Western men, even though the proportion of organ-confined disease reached to that of Western series. Conclusion: Korean men with prostate cancer currently present better clinicopathologic parameters. However, in comparison, Korean men still show relatively worse pathologic Gleason scores than Western men.

Original languageEnglish
Pages (from-to)543-549
Number of pages7
JournalYonsei medical journal
Volume53
Issue number3
DOIs
Publication statusPublished - 2012 May 1

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Neoplasm Grading
Prostatic Neoplasms
Population
Korea
Prostate-Specific Antigen
Prostatectomy
Biopsy

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Byun, Seok Soo ; Lee, Sangchul ; Lee, Sang Eun ; Lee, Eunsik ; Seo, Seong Il ; Lee, Hyun Moo ; Choi, Han Yong ; Song, Cheryn ; Ahn, Hanjong ; Choi, Young Deuk ; Cho, Jin Seon. / Recent changes in the clinicopathologic features of Korean men with prostate cancer : A comparison with Western populations. In: Yonsei medical journal. 2012 ; Vol. 53, No. 3. pp. 543-549.
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title = "Recent changes in the clinicopathologic features of Korean men with prostate cancer: A comparison with Western populations",
abstract = "Purpose: The aim of this study was to evaluate the recent changes in the clinicopathologic features of prostate cancer in Korea and to compare these features with those of Western populations. Materials and Methods: We retrospectively reviewed the data of 1582 men undergoing radical prostatectomy for clinically localized prostate cancer between 1995 and 2007 at 10 institutions in Korea for comparison with Western studies. The patients were divided into two groups in order to evaluate the recent clinicopathological changes in prostate cancer: Group 1 had surgery between 1995 and 2003 (n=280) and Group 2 had surgery between 2004 and 2007 (n=1302). The mean follow-up period was 24 months. Results: Group 1 had a higher prostate-specific antigen level than Group 2 (10.0 ng/mL vs. 7.5 ng/mL, respectively; p<0.001) and a lower proportion of biopsy Gleason scores ≤6 (35.0{\%} vs. 48.1{\%}, respectively; p<0.001). The proportion of patients with clinical T1 stage was higher in Group 2 than in Group 1. Group 1 had a lower proportion of organ-confined disease (59.6{\%} vs. 68.6{\%}; p<0.001) and a lower proportion of Gleason scores ≤6 (21.3{\%} vs. 33.0{\%}; p<0.001), compared to Group 2. However, the relatively higher proportion of pathologic Gleason scores ≤6 in Group 2 was still lower than those of Western men, even though the proportion of organ-confined disease reached to that of Western series. Conclusion: Korean men with prostate cancer currently present better clinicopathologic parameters. However, in comparison, Korean men still show relatively worse pathologic Gleason scores than Western men.",
author = "Byun, {Seok Soo} and Sangchul Lee and Lee, {Sang Eun} and Eunsik Lee and Seo, {Seong Il} and Lee, {Hyun Moo} and Choi, {Han Yong} and Cheryn Song and Hanjong Ahn and Choi, {Young Deuk} and Cho, {Jin Seon}",
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Byun, SS, Lee, S, Lee, SE, Lee, E, Seo, SI, Lee, HM, Choi, HY, Song, C, Ahn, H, Choi, YD & Cho, JS 2012, 'Recent changes in the clinicopathologic features of Korean men with prostate cancer: A comparison with Western populations', Yonsei medical journal, vol. 53, no. 3, pp. 543-549. https://doi.org/10.3349/ymj.2012.53.3.543

Recent changes in the clinicopathologic features of Korean men with prostate cancer : A comparison with Western populations. / Byun, Seok Soo; Lee, Sangchul; Lee, Sang Eun; Lee, Eunsik; Seo, Seong Il; Lee, Hyun Moo; Choi, Han Yong; Song, Cheryn; Ahn, Hanjong; Choi, Young Deuk; Cho, Jin Seon.

In: Yonsei medical journal, Vol. 53, No. 3, 01.05.2012, p. 543-549.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Recent changes in the clinicopathologic features of Korean men with prostate cancer

T2 - A comparison with Western populations

AU - Byun, Seok Soo

AU - Lee, Sangchul

AU - Lee, Sang Eun

AU - Lee, Eunsik

AU - Seo, Seong Il

AU - Lee, Hyun Moo

AU - Choi, Han Yong

AU - Song, Cheryn

AU - Ahn, Hanjong

AU - Choi, Young Deuk

AU - Cho, Jin Seon

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Purpose: The aim of this study was to evaluate the recent changes in the clinicopathologic features of prostate cancer in Korea and to compare these features with those of Western populations. Materials and Methods: We retrospectively reviewed the data of 1582 men undergoing radical prostatectomy for clinically localized prostate cancer between 1995 and 2007 at 10 institutions in Korea for comparison with Western studies. The patients were divided into two groups in order to evaluate the recent clinicopathological changes in prostate cancer: Group 1 had surgery between 1995 and 2003 (n=280) and Group 2 had surgery between 2004 and 2007 (n=1302). The mean follow-up period was 24 months. Results: Group 1 had a higher prostate-specific antigen level than Group 2 (10.0 ng/mL vs. 7.5 ng/mL, respectively; p<0.001) and a lower proportion of biopsy Gleason scores ≤6 (35.0% vs. 48.1%, respectively; p<0.001). The proportion of patients with clinical T1 stage was higher in Group 2 than in Group 1. Group 1 had a lower proportion of organ-confined disease (59.6% vs. 68.6%; p<0.001) and a lower proportion of Gleason scores ≤6 (21.3% vs. 33.0%; p<0.001), compared to Group 2. However, the relatively higher proportion of pathologic Gleason scores ≤6 in Group 2 was still lower than those of Western men, even though the proportion of organ-confined disease reached to that of Western series. Conclusion: Korean men with prostate cancer currently present better clinicopathologic parameters. However, in comparison, Korean men still show relatively worse pathologic Gleason scores than Western men.

AB - Purpose: The aim of this study was to evaluate the recent changes in the clinicopathologic features of prostate cancer in Korea and to compare these features with those of Western populations. Materials and Methods: We retrospectively reviewed the data of 1582 men undergoing radical prostatectomy for clinically localized prostate cancer between 1995 and 2007 at 10 institutions in Korea for comparison with Western studies. The patients were divided into two groups in order to evaluate the recent clinicopathological changes in prostate cancer: Group 1 had surgery between 1995 and 2003 (n=280) and Group 2 had surgery between 2004 and 2007 (n=1302). The mean follow-up period was 24 months. Results: Group 1 had a higher prostate-specific antigen level than Group 2 (10.0 ng/mL vs. 7.5 ng/mL, respectively; p<0.001) and a lower proportion of biopsy Gleason scores ≤6 (35.0% vs. 48.1%, respectively; p<0.001). The proportion of patients with clinical T1 stage was higher in Group 2 than in Group 1. Group 1 had a lower proportion of organ-confined disease (59.6% vs. 68.6%; p<0.001) and a lower proportion of Gleason scores ≤6 (21.3% vs. 33.0%; p<0.001), compared to Group 2. However, the relatively higher proportion of pathologic Gleason scores ≤6 in Group 2 was still lower than those of Western men, even though the proportion of organ-confined disease reached to that of Western series. Conclusion: Korean men with prostate cancer currently present better clinicopathologic parameters. However, in comparison, Korean men still show relatively worse pathologic Gleason scores than Western men.

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U2 - 10.3349/ymj.2012.53.3.543

DO - 10.3349/ymj.2012.53.3.543

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JO - Yonsei Medical Journal

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