Abstract
External beam radiotherapy (EBRT) for hepatocellular carcinoma (HCC) has not been widely used due to lack of high-level evidence, despite its potent local therapeutic effect. While clinical evidence has accumulated and meta-analyses of observational studies have provided integrated information to help in clinical decision-making, a recent randomized trial demonstrated the benefit of EBRT in cases of HCC with major vessel invasion. Based on these trends, the efficacy of EBRT has been better recognized, and EBRT has been more frequently recommended in several international treatment guidelines newly updated in 2018. This review examined the key issues of EBRT in the guidelines updated in 2018 as well as recently published noteworthy randomized trials and meta-analyses. Ongoing trials to identify the trends and direction of future research on EBRT for HCC were also reviewed.
| Original language | English |
|---|---|
| Pages (from-to) | 812-821 |
| Number of pages | 10 |
| Journal | Journal of Medical Imaging and Radiation Oncology |
| Volume | 63 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2019 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Radiology Nuclear Medicine and imaging
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Recent clinical applications of external beam radiotherapy for hepatocellular carcinoma according to guidelines, major trials and meta-analyses. / Rim, Chai Hong; Yim, Hyung Joon; Park, Sunmin; Seong, Jinsil.
In: Journal of Medical Imaging and Radiation Oncology, Vol. 63, No. 6, 01.12.2019, p. 812-821.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Recent clinical applications of external beam radiotherapy for hepatocellular carcinoma according to guidelines, major trials and meta-analyses
AU - Rim, Chai Hong
AU - Yim, Hyung Joon
AU - Park, Sunmin
AU - Seong, Jinsil
PY - 2019/12/1
Y1 - 2019/12/1
N2 - External beam radiotherapy (EBRT) for hepatocellular carcinoma (HCC) has not been widely used due to lack of high-level evidence, despite its potent local therapeutic effect. While clinical evidence has accumulated and meta-analyses of observational studies have provided integrated information to help in clinical decision-making, a recent randomized trial demonstrated the benefit of EBRT in cases of HCC with major vessel invasion. Based on these trends, the efficacy of EBRT has been better recognized, and EBRT has been more frequently recommended in several international treatment guidelines newly updated in 2018. This review examined the key issues of EBRT in the guidelines updated in 2018 as well as recently published noteworthy randomized trials and meta-analyses. Ongoing trials to identify the trends and direction of future research on EBRT for HCC were also reviewed.
AB - External beam radiotherapy (EBRT) for hepatocellular carcinoma (HCC) has not been widely used due to lack of high-level evidence, despite its potent local therapeutic effect. While clinical evidence has accumulated and meta-analyses of observational studies have provided integrated information to help in clinical decision-making, a recent randomized trial demonstrated the benefit of EBRT in cases of HCC with major vessel invasion. Based on these trends, the efficacy of EBRT has been better recognized, and EBRT has been more frequently recommended in several international treatment guidelines newly updated in 2018. This review examined the key issues of EBRT in the guidelines updated in 2018 as well as recently published noteworthy randomized trials and meta-analyses. Ongoing trials to identify the trends and direction of future research on EBRT for HCC were also reviewed.
UR - http://www.scopus.com/inward/record.url?scp=85071773350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071773350&partnerID=8YFLogxK
U2 - 10.1111/1754-9485.12948
DO - 10.1111/1754-9485.12948
M3 - Review article
C2 - 31482683
AN - SCOPUS:85071773350
VL - 63
SP - 812
EP - 821
JO - Journal of Medical Imaging and Radiation Oncology
JF - Journal of Medical Imaging and Radiation Oncology
SN - 1754-9477
IS - 6
ER -