Recent clinical applications of external beam radiotherapy for hepatocellular carcinoma according to guidelines, major trials and meta-analyses

Chai Hong Rim; Hyung Joon Yim; Sunmin Park; Jinsil Seong

doi:10.1111/1754-9485.12948

Recent clinical applications of external beam radiotherapy for hepatocellular carcinoma according to guidelines, major trials and meta-analyses

Chai Hong Rim, Hyung Joon Yim, Sunmin Park, Jinsil Seong

Department of Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

External beam radiotherapy (EBRT) for hepatocellular carcinoma (HCC) has not been widely used due to lack of high-level evidence, despite its potent local therapeutic effect. While clinical evidence has accumulated and meta-analyses of observational studies have provided integrated information to help in clinical decision-making, a recent randomized trial demonstrated the benefit of EBRT in cases of HCC with major vessel invasion. Based on these trends, the efficacy of EBRT has been better recognized, and EBRT has been more frequently recommended in several international treatment guidelines newly updated in 2018. This review examined the key issues of EBRT in the guidelines updated in 2018 as well as recently published noteworthy randomized trials and meta-analyses. Ongoing trials to identify the trends and direction of future research on EBRT for HCC were also reviewed.

Original language	English
Pages (from-to)	812-821
Number of pages	10
Journal	Journal of Medical Imaging and Radiation Oncology
Volume	63
Issue number	6
DOIs	https://doi.org/10.1111/1754-9485.12948
Publication status	Published - 2019 Dec 1

Bibliographical note

Funding Information:
This study was supported by the National Research Fund of Korea (NRF-2018R1D1A1B07046998).

Publisher Copyright:
© 2019 The Royal Australian and New Zealand College of Radiologists

All Science Journal Classification (ASJC) codes

Oncology
Radiology Nuclear Medicine and imaging

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title = "Recent clinical applications of external beam radiotherapy for hepatocellular carcinoma according to guidelines, major trials and meta-analyses",

abstract = "External beam radiotherapy (EBRT) for hepatocellular carcinoma (HCC) has not been widely used due to lack of high-level evidence, despite its potent local therapeutic effect. While clinical evidence has accumulated and meta-analyses of observational studies have provided integrated information to help in clinical decision-making, a recent randomized trial demonstrated the benefit of EBRT in cases of HCC with major vessel invasion. Based on these trends, the efficacy of EBRT has been better recognized, and EBRT has been more frequently recommended in several international treatment guidelines newly updated in 2018. This review examined the key issues of EBRT in the guidelines updated in 2018 as well as recently published noteworthy randomized trials and meta-analyses. Ongoing trials to identify the trends and direction of future research on EBRT for HCC were also reviewed.",

author = "Rim, {Chai Hong} and Yim, {Hyung Joon} and Sunmin Park and Jinsil Seong",

note = "Funding Information: This study was supported by the National Research Fund of Korea (NRF-2018R1D1A1B07046998). Publisher Copyright: {\textcopyright} 2019 The Royal Australian and New Zealand College of Radiologists",

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Recent clinical applications of external beam radiotherapy for hepatocellular carcinoma according to guidelines, major trials and meta-analyses. / Rim, Chai Hong; Yim, Hyung Joon; Park, Sunmin; Seong, Jinsil.

In: Journal of Medical Imaging and Radiation Oncology, Vol. 63, No. 6, 01.12.2019, p. 812-821.

Research output: Contribution to journal › Review article › peer-review

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N1 - Funding Information: This study was supported by the National Research Fund of Korea (NRF-2018R1D1A1B07046998). Publisher Copyright: © 2019 The Royal Australian and New Zealand College of Radiologists

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Recent clinical applications of external beam radiotherapy for hepatocellular carcinoma according to guidelines, major trials and meta-analyses

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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