Recent developments in texaphyrin chemistry and drug discovery

Christian Preihs, Jonathan F. Arambula, Darren Magda, Heeyeong Jeong, Dongwon Yoo, Jinwoo Cheon, Zahid H. Siddik, Jonathan L. Sessler

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Texaphyrins are pentaaza expanded porphyrins with the ability to form stable complexes with a variety of metal cations, particularly those of the lanthanide series. In biological milieus, texaphyrins act as redox mediators and mediate the production of reactive oxygen species (ROS). In this review, newer studies involving texaphyrin complexes targeting several different applications in anticancer therapy are described. In particular, the preparation of bismuth and lead texaphyrin complexes as potential α-core emitters for radiotherapy is detailed, as are gadolinium texaphyrin functionalized magnetic nanoparticles with features that make them of interest as dual-mode magnetic resonance imaging contrast agents and as constructs with anticancer activity mediated through ROS-induced sensitization and concurrent hyperthermia. Also discussed are gadolinium texaphyrin complexes as possible carrier systems for the targeted delivery of platinum payloads.

Original languageEnglish
Pages (from-to)12184-12192
Number of pages9
JournalInorganic Chemistry
Volume52
Issue number21
DOIs
Publication statusPublished - 2013 Nov 4

Fingerprint

gadolinium
drugs
chemistry
hyperthermia
wireless communication
oxygen
payloads
porphyrins
bismuth
magnetic resonance
radiation therapy
therapy
Reactive Oxygen Species
delivery
emitters
platinum
cations
Lanthanoid Series Elements
nanoparticles
preparation

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

Cite this

Preihs, C., Arambula, J. F., Magda, D., Jeong, H., Yoo, D., Cheon, J., ... Sessler, J. L. (2013). Recent developments in texaphyrin chemistry and drug discovery. Inorganic Chemistry, 52(21), 12184-12192. https://doi.org/10.1021/ic400226g
Preihs, Christian ; Arambula, Jonathan F. ; Magda, Darren ; Jeong, Heeyeong ; Yoo, Dongwon ; Cheon, Jinwoo ; Siddik, Zahid H. ; Sessler, Jonathan L. / Recent developments in texaphyrin chemistry and drug discovery. In: Inorganic Chemistry. 2013 ; Vol. 52, No. 21. pp. 12184-12192.
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Preihs, C, Arambula, JF, Magda, D, Jeong, H, Yoo, D, Cheon, J, Siddik, ZH & Sessler, JL 2013, 'Recent developments in texaphyrin chemistry and drug discovery', Inorganic Chemistry, vol. 52, no. 21, pp. 12184-12192. https://doi.org/10.1021/ic400226g

Recent developments in texaphyrin chemistry and drug discovery. / Preihs, Christian; Arambula, Jonathan F.; Magda, Darren; Jeong, Heeyeong; Yoo, Dongwon; Cheon, Jinwoo; Siddik, Zahid H.; Sessler, Jonathan L.

In: Inorganic Chemistry, Vol. 52, No. 21, 04.11.2013, p. 12184-12192.

Research output: Contribution to journalArticle

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Preihs C, Arambula JF, Magda D, Jeong H, Yoo D, Cheon J et al. Recent developments in texaphyrin chemistry and drug discovery. Inorganic Chemistry. 2013 Nov 4;52(21):12184-12192. https://doi.org/10.1021/ic400226g