Reciprocal activation of the orbitofrontal cortex and the ventrolateral prefrontal cortex in processing ambivalent stimuli

Young Chul Jung, Hae Jeong Park, Jae Jin Kim, Ji Won Chun, Hye Sun Kim, Nam Wook Kim, Sang Jun Son, Maeng Gun Oh, Jong Doo Lee

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The neural basis of ambivalence has not yet been identified. We investigated the prefrontal cortical activations implicated in evaluative processing of ambivalent stimuli under the forced and non-forced response conditions. Cerebral blood flow was measured using H215O positron emission tomography in twelve normal volunteers during a modified word-stem completion task that was designed to evoke different conditions of ambivalence. The prefrontal cortical activations were restricted to the orbitofrontal cortex during the non-forced ambivalent condition, whereas the ventrolateral prefrontal cortex and the frontopolar cortex were activated in addition to the orbitofrontal cortex during the forced ambivalent condition. It is remarkable that the orbitofrontal cortex and the ventrolateral prefrontal cortex demonstrated a reciprocal activation pattern, which might be linked to the evaluative attitude toward the ambivalent stimuli.

Original languageEnglish
Pages (from-to)136-143
Number of pages8
JournalBrain Research
Volume1246
DOIs
Publication statusPublished - 2008 Dec 30

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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