The 12/15-lipoxygenase (12/15-LOX) pathways of arachidonate metabolism have been implicated in the pathogenesis of psoriasis. Since UV photo-therapy is a commonly used technique for inhibiting cell proliferation and inflammation in skin diseases, we hypothesized that UV-irradiation may affect 12/15-LOX expression which might regulate cell proliferation. In this study, we showed that UV-irradiation suppressed 12-LOX expression, whereas up-regulated 15-LOX expression. Treatment with the 15-LOX metabolites sufficiently suppressed insulin-like growth factor II-induced 12-LOX expression and blocked cell cycle progression. On the basis of our findings, we think that the 15-LOX metabolites may inhibit epidermal hyperplasia in psoriasis by regulating 12-LOX expression.
Bibliographical noteFunding Information:
This work was supported by a Next Generation Growth Engine Program Grant (M10416020002-05N1602) from the Korean Science and Engineering Foundation and the Korean Ministry of Science and Technology. We thank Prof. N. Fusenig for providing the HaCaT cells.
All Science Journal Classification (ASJC) codes
- Structural Biology
- Molecular Biology
- Cell Biology