Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes

Hyun Yoo, Byeongwook Jeon, Myung Shin Jeon, Hyangkyu Lee, Tae Yoon Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The 12/15-lipoxygenase (12/15-LOX) pathways of arachidonate metabolism have been implicated in the pathogenesis of psoriasis. Since UV photo-therapy is a commonly used technique for inhibiting cell proliferation and inflammation in skin diseases, we hypothesized that UV-irradiation may affect 12/15-LOX expression which might regulate cell proliferation. In this study, we showed that UV-irradiation suppressed 12-LOX expression, whereas up-regulated 15-LOX expression. Treatment with the 15-LOX metabolites sufficiently suppressed insulin-like growth factor II-induced 12-LOX expression and blocked cell cycle progression. On the basis of our findings, we think that the 15-LOX metabolites may inhibit epidermal hyperplasia in psoriasis by regulating 12-LOX expression.

Original languageEnglish
Pages (from-to)3249-3253
Number of pages5
JournalFEBS Letters
Volume582
Issue number21-22
DOIs
Publication statusPublished - 2008 Sep 22

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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