Recrystallization of fluconazole using the supercritical antisolvent (SAS) process

Hee Jun Park, Min Soo Kim, Sibeum Lee, Jeong Soo Kim, Jong Soo Woo, Jeong Sook Park, Sung Joo Hwang

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The supercritical antisolvent (SAS) process was used to modify solid state characteristics of fluconazole. Fluconazole was recrystallized at various temperatures (60-80 °C) and pressures (8-16 MPa) using dichloromethane (DCM) as a solvent. Acetone and ethanol were also employed as solvents. The fluconazole polymorphs prepared by the SAS process were characterized by differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). Furthermore, the equilibrium solubility of the samples in aqueous solution was determined. Fluconazole anhydrate form I was obtained at low temperature (40 °C) and anhydrate form II was obtained at high temperature (80 °C). The variation of pressure during the SAS process may influence the preferred orientation. Anhydrate forms I and II were also obtained using various solvents. Therefore, it was shown that solid state characteristics of fluconazole, including the polymorphic form and preferred orientation, can be controlled by changing operating conditions of the SAS process such as temperature, pressure, and solvent.

Original languageEnglish
Pages (from-to)152-160
Number of pages9
JournalInternational Journal of Pharmaceutics
Volume328
Issue number2
DOIs
Publication statusPublished - 2007 Jan 10

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Fluconazole
Temperature
Pressure
Thermogravimetry
Methylene Chloride
Differential Scanning Calorimetry
Fourier Transform Infrared Spectroscopy
Acetone
X-Ray Diffraction
Electron Scanning Microscopy
Powders
Solubility
Ethanol

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Park, Hee Jun ; Kim, Min Soo ; Lee, Sibeum ; Kim, Jeong Soo ; Woo, Jong Soo ; Park, Jeong Sook ; Hwang, Sung Joo. / Recrystallization of fluconazole using the supercritical antisolvent (SAS) process. In: International Journal of Pharmaceutics. 2007 ; Vol. 328, No. 2. pp. 152-160.
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Recrystallization of fluconazole using the supercritical antisolvent (SAS) process. / Park, Hee Jun; Kim, Min Soo; Lee, Sibeum; Kim, Jeong Soo; Woo, Jong Soo; Park, Jeong Sook; Hwang, Sung Joo.

In: International Journal of Pharmaceutics, Vol. 328, No. 2, 10.01.2007, p. 152-160.

Research output: Contribution to journalArticle

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