Recurrence outcomes after omission of postoperative radiotherapy following breast-conserving surgery for ductal carcinoma in situ of the breast: a multicenter, retrospective study in Korea (KROG 16-02)

Kyubo Kim, So Youn Jung, Kyung Hwan Shin, Jin Ho Kim, Wonshik Han, Han Byoel Lee, Seung Jae Huh, Doo Ho Choi, Won Park, Seung Do Ahn, Su Ssan Kim, Jin Hee Kim, Chang Ok Suh, Yong Bae Kim, In Ah Kim, Suzy Kim, Yi Jun Kim

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Abstract

Purpose: To evaluate the loco-regional recurrence (LRR) rate after breast-conserving surgery without postoperative radiotherapy (RT) for ductal carcinoma in situ (DCIS) of the breast. Methods: Between 2000 and 2010, 311 DCIS patients from 9 institutions were analyzed retrospectively. The median age was 47 (range, 20–82). The median tumor size was 7 mm (range, 0.01–76). Margin width was <1 cm in 85 patients (27.3%), and nuclear grade was high in 37 patients (11.9%). Two hundred and three patients (65.3%) received tamoxifen. Results: With a median follow-up of 74 months (range, 5–189), there were 11 local recurrences (invasive carcinoma in 6 and DCIS in 5) and 1 regional recurrence. The 7-year LRR rate was 3.8%. On univariate analysis, age and margin width were significant risk factors influencing LRR (p = 0.017 and 0.014, respectively). When age and margin width were combined among 211 patients whose margin width were available, the 7-year LRR rates were as follows (p < 0.001): (1) 0% in patients with age >50 years and any margin width status (n = 64), (2) 1.2% in age ≤50 years and margin width ≥1 cm (n = 93), (3) 13.1% in age ≤50 years and margin width <1 cm (n = 54). Conclusions: The LRR rate was very low in selected DCIS patients treated with breast-conserving surgery without postoperative RT. However, adjuvant RT should be considered for those with age ≤50 years and margin width <1 cm.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalBreast Cancer Research and Treatment
Volume162
Issue number1
DOIs
Publication statusPublished - 2017 Feb 1

Bibliographical note

Publisher Copyright:
© 2017, Springer Science+Business Media New York.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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