Recurrence outcomes after omission of postoperative radiotherapy following breast-conserving surgery for ductal carcinoma in situ of the breast

a multicenter, retrospective study in Korea (KROG 16-02)

Kyubo Kim, So Youn Jung, Kyung Hwan Shin, Jin Ho Kim, Wonshik Han, Han Byoel Lee, Seung Jae Huh, Doo Ho Choi, Won Park, Seung Do Ahn, Su Ssan Kim, Jin Hee Kim, Chang-Ok Suh, Yongbae Kim, In Ah Kim, Suzy Kim, Yi Jun Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To evaluate the loco-regional recurrence (LRR) rate after breast-conserving surgery without postoperative radiotherapy (RT) for ductal carcinoma in situ (DCIS) of the breast. Methods: Between 2000 and 2010, 311 DCIS patients from 9 institutions were analyzed retrospectively. The median age was 47 (range, 20–82). The median tumor size was 7 mm (range, 0.01–76). Margin width was <1 cm in 85 patients (27.3%), and nuclear grade was high in 37 patients (11.9%). Two hundred and three patients (65.3%) received tamoxifen. Results: With a median follow-up of 74 months (range, 5–189), there were 11 local recurrences (invasive carcinoma in 6 and DCIS in 5) and 1 regional recurrence. The 7-year LRR rate was 3.8%. On univariate analysis, age and margin width were significant risk factors influencing LRR (p = 0.017 and 0.014, respectively). When age and margin width were combined among 211 patients whose margin width were available, the 7-year LRR rates were as follows (p < 0.001): (1) 0% in patients with age >50 years and any margin width status (n = 64), (2) 1.2% in age ≤50 years and margin width ≥1 cm (n = 93), (3) 13.1% in age ≤50 years and margin width <1 cm (n = 54). Conclusions: The LRR rate was very low in selected DCIS patients treated with breast-conserving surgery without postoperative RT. However, adjuvant RT should be considered for those with age ≤50 years and margin width <1 cm.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalBreast Cancer Research and Treatment
Volume162
Issue number1
DOIs
Publication statusPublished - 2017 Feb 1

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Carcinoma, Intraductal, Noninfiltrating
Segmental Mastectomy
Korea
Multicenter Studies
Breast
Radiotherapy
Retrospective Studies
Recurrence
Adjuvant Radiotherapy
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kim, Kyubo ; Jung, So Youn ; Shin, Kyung Hwan ; Kim, Jin Ho ; Han, Wonshik ; Lee, Han Byoel ; Huh, Seung Jae ; Choi, Doo Ho ; Park, Won ; Ahn, Seung Do ; Kim, Su Ssan ; Kim, Jin Hee ; Suh, Chang-Ok ; Kim, Yongbae ; Kim, In Ah ; Kim, Suzy ; Kim, Yi Jun. / Recurrence outcomes after omission of postoperative radiotherapy following breast-conserving surgery for ductal carcinoma in situ of the breast : a multicenter, retrospective study in Korea (KROG 16-02). In: Breast Cancer Research and Treatment. 2017 ; Vol. 162, No. 1. pp. 77-83.
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title = "Recurrence outcomes after omission of postoperative radiotherapy following breast-conserving surgery for ductal carcinoma in situ of the breast: a multicenter, retrospective study in Korea (KROG 16-02)",
abstract = "Purpose: To evaluate the loco-regional recurrence (LRR) rate after breast-conserving surgery without postoperative radiotherapy (RT) for ductal carcinoma in situ (DCIS) of the breast. Methods: Between 2000 and 2010, 311 DCIS patients from 9 institutions were analyzed retrospectively. The median age was 47 (range, 20–82). The median tumor size was 7 mm (range, 0.01–76). Margin width was <1 cm in 85 patients (27.3{\%}), and nuclear grade was high in 37 patients (11.9{\%}). Two hundred and three patients (65.3{\%}) received tamoxifen. Results: With a median follow-up of 74 months (range, 5–189), there were 11 local recurrences (invasive carcinoma in 6 and DCIS in 5) and 1 regional recurrence. The 7-year LRR rate was 3.8{\%}. On univariate analysis, age and margin width were significant risk factors influencing LRR (p = 0.017 and 0.014, respectively). When age and margin width were combined among 211 patients whose margin width were available, the 7-year LRR rates were as follows (p < 0.001): (1) 0{\%} in patients with age >50 years and any margin width status (n = 64), (2) 1.2{\%} in age ≤50 years and margin width ≥1 cm (n = 93), (3) 13.1{\%} in age ≤50 years and margin width <1 cm (n = 54). Conclusions: The LRR rate was very low in selected DCIS patients treated with breast-conserving surgery without postoperative RT. However, adjuvant RT should be considered for those with age ≤50 years and margin width <1 cm.",
author = "Kyubo Kim and Jung, {So Youn} and Shin, {Kyung Hwan} and Kim, {Jin Ho} and Wonshik Han and Lee, {Han Byoel} and Huh, {Seung Jae} and Choi, {Doo Ho} and Won Park and Ahn, {Seung Do} and Kim, {Su Ssan} and Kim, {Jin Hee} and Chang-Ok Suh and Yongbae Kim and Kim, {In Ah} and Suzy Kim and Kim, {Yi Jun}",
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Recurrence outcomes after omission of postoperative radiotherapy following breast-conserving surgery for ductal carcinoma in situ of the breast : a multicenter, retrospective study in Korea (KROG 16-02). / Kim, Kyubo; Jung, So Youn; Shin, Kyung Hwan; Kim, Jin Ho; Han, Wonshik; Lee, Han Byoel; Huh, Seung Jae; Choi, Doo Ho; Park, Won; Ahn, Seung Do; Kim, Su Ssan; Kim, Jin Hee; Suh, Chang-Ok; Kim, Yongbae; Kim, In Ah; Kim, Suzy; Kim, Yi Jun.

In: Breast Cancer Research and Treatment, Vol. 162, No. 1, 01.02.2017, p. 77-83.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Recurrence outcomes after omission of postoperative radiotherapy following breast-conserving surgery for ductal carcinoma in situ of the breast

T2 - a multicenter, retrospective study in Korea (KROG 16-02)

AU - Kim, Kyubo

AU - Jung, So Youn

AU - Shin, Kyung Hwan

AU - Kim, Jin Ho

AU - Han, Wonshik

AU - Lee, Han Byoel

AU - Huh, Seung Jae

AU - Choi, Doo Ho

AU - Park, Won

AU - Ahn, Seung Do

AU - Kim, Su Ssan

AU - Kim, Jin Hee

AU - Suh, Chang-Ok

AU - Kim, Yongbae

AU - Kim, In Ah

AU - Kim, Suzy

AU - Kim, Yi Jun

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Purpose: To evaluate the loco-regional recurrence (LRR) rate after breast-conserving surgery without postoperative radiotherapy (RT) for ductal carcinoma in situ (DCIS) of the breast. Methods: Between 2000 and 2010, 311 DCIS patients from 9 institutions were analyzed retrospectively. The median age was 47 (range, 20–82). The median tumor size was 7 mm (range, 0.01–76). Margin width was <1 cm in 85 patients (27.3%), and nuclear grade was high in 37 patients (11.9%). Two hundred and three patients (65.3%) received tamoxifen. Results: With a median follow-up of 74 months (range, 5–189), there were 11 local recurrences (invasive carcinoma in 6 and DCIS in 5) and 1 regional recurrence. The 7-year LRR rate was 3.8%. On univariate analysis, age and margin width were significant risk factors influencing LRR (p = 0.017 and 0.014, respectively). When age and margin width were combined among 211 patients whose margin width were available, the 7-year LRR rates were as follows (p < 0.001): (1) 0% in patients with age >50 years and any margin width status (n = 64), (2) 1.2% in age ≤50 years and margin width ≥1 cm (n = 93), (3) 13.1% in age ≤50 years and margin width <1 cm (n = 54). Conclusions: The LRR rate was very low in selected DCIS patients treated with breast-conserving surgery without postoperative RT. However, adjuvant RT should be considered for those with age ≤50 years and margin width <1 cm.

AB - Purpose: To evaluate the loco-regional recurrence (LRR) rate after breast-conserving surgery without postoperative radiotherapy (RT) for ductal carcinoma in situ (DCIS) of the breast. Methods: Between 2000 and 2010, 311 DCIS patients from 9 institutions were analyzed retrospectively. The median age was 47 (range, 20–82). The median tumor size was 7 mm (range, 0.01–76). Margin width was <1 cm in 85 patients (27.3%), and nuclear grade was high in 37 patients (11.9%). Two hundred and three patients (65.3%) received tamoxifen. Results: With a median follow-up of 74 months (range, 5–189), there were 11 local recurrences (invasive carcinoma in 6 and DCIS in 5) and 1 regional recurrence. The 7-year LRR rate was 3.8%. On univariate analysis, age and margin width were significant risk factors influencing LRR (p = 0.017 and 0.014, respectively). When age and margin width were combined among 211 patients whose margin width were available, the 7-year LRR rates were as follows (p < 0.001): (1) 0% in patients with age >50 years and any margin width status (n = 64), (2) 1.2% in age ≤50 years and margin width ≥1 cm (n = 93), (3) 13.1% in age ≤50 years and margin width <1 cm (n = 54). Conclusions: The LRR rate was very low in selected DCIS patients treated with breast-conserving surgery without postoperative RT. However, adjuvant RT should be considered for those with age ≤50 years and margin width <1 cm.

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U2 - 10.1007/s10549-017-4111-1

DO - 10.1007/s10549-017-4111-1

M3 - Article

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EP - 83

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 1

ER -