Recursive partition analysis of peritoneal and systemic recurrence in patients with gastric cancer who underwent D2 gastrectomy

Implications for neoadjuvant therapy consideration

Jee Suk Chang, Kyung Hwan Kim, Ki Chang Keum, Sung Hoon Noh, Joon Seok Lim, Hyo Song Kim, SunYoung Rha, Yongchan Lee, WooJin Hyung, Woong Sub Koom

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and Objectives: To classify patients with nonmetastatic advanced gastric cancer who underwent D2-gastrectomy into prognostic groups based on peritoneal and systemic recurrence risks. Methods: Between 2004 and 2007, 1,090 patients with T3–4 or N+ gastric cancer were identified from our registry. Recurrence rates were estimated using a competing-risk analysis. Different prognostic groups were defined using recursive partitioning analysis (RPA). Results: Median follow-up was 7 years. In the RPA-model for peritoneal recurrence risk, the initial node was split by T stage, indicating that differences between patients with T1–3 and T4 cancer were the greatest. The 5-year peritoneal recurrence rates for patients with T4 (n = 627) and T1–3 (n = 463) disease were 34.3% and 9.1%, respectively. N stage and neural invasion had an additive impact on high-risk patients. The RPA model for systemic relapse incorporated N stage alone and gave two terminal nodes: N0–2 (n = 721) and N3 (n = 369). The 5-year cumulative incidences were 7.7% and 24.5%, respectively. Conclusions: We proposed risk stratification models of peritoneal and systemic recurrence in patients undergoing D2-gastrectomy. This classification could be used for stratification protocols in future studies evaluating adjuvant therapies such as preoperative chemoradiotherapy. J. Surg. Oncol. 2016;114:859–864.

Original languageEnglish
Pages (from-to)859-864
Number of pages6
JournalJournal of Surgical Oncology
Volume114
Issue number7
DOIs
Publication statusPublished - 2016 Dec 1

Fingerprint

Neoadjuvant Therapy
Gastrectomy
Stomach Neoplasms
Recurrence
Chemoradiotherapy
Registries
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

@article{3b4facfe164b492e950d7789849bdff9,
title = "Recursive partition analysis of peritoneal and systemic recurrence in patients with gastric cancer who underwent D2 gastrectomy: Implications for neoadjuvant therapy consideration",
abstract = "Background and Objectives: To classify patients with nonmetastatic advanced gastric cancer who underwent D2-gastrectomy into prognostic groups based on peritoneal and systemic recurrence risks. Methods: Between 2004 and 2007, 1,090 patients with T3–4 or N+ gastric cancer were identified from our registry. Recurrence rates were estimated using a competing-risk analysis. Different prognostic groups were defined using recursive partitioning analysis (RPA). Results: Median follow-up was 7 years. In the RPA-model for peritoneal recurrence risk, the initial node was split by T stage, indicating that differences between patients with T1–3 and T4 cancer were the greatest. The 5-year peritoneal recurrence rates for patients with T4 (n = 627) and T1–3 (n = 463) disease were 34.3{\%} and 9.1{\%}, respectively. N stage and neural invasion had an additive impact on high-risk patients. The RPA model for systemic relapse incorporated N stage alone and gave two terminal nodes: N0–2 (n = 721) and N3 (n = 369). The 5-year cumulative incidences were 7.7{\%} and 24.5{\%}, respectively. Conclusions: We proposed risk stratification models of peritoneal and systemic recurrence in patients undergoing D2-gastrectomy. This classification could be used for stratification protocols in future studies evaluating adjuvant therapies such as preoperative chemoradiotherapy. J. Surg. Oncol. 2016;114:859–864.",
author = "Chang, {Jee Suk} and Kim, {Kyung Hwan} and Keum, {Ki Chang} and Noh, {Sung Hoon} and Lim, {Joon Seok} and Kim, {Hyo Song} and SunYoung Rha and Yongchan Lee and WooJin Hyung and Koom, {Woong Sub}",
year = "2016",
month = "12",
day = "1",
doi = "10.1002/jso.24405",
language = "English",
volume = "114",
pages = "859--864",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "7",

}

Recursive partition analysis of peritoneal and systemic recurrence in patients with gastric cancer who underwent D2 gastrectomy : Implications for neoadjuvant therapy consideration. / Chang, Jee Suk; Kim, Kyung Hwan; Keum, Ki Chang; Noh, Sung Hoon; Lim, Joon Seok; Kim, Hyo Song; Rha, SunYoung; Lee, Yongchan; Hyung, WooJin; Koom, Woong Sub.

In: Journal of Surgical Oncology, Vol. 114, No. 7, 01.12.2016, p. 859-864.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Recursive partition analysis of peritoneal and systemic recurrence in patients with gastric cancer who underwent D2 gastrectomy

T2 - Implications for neoadjuvant therapy consideration

AU - Chang, Jee Suk

AU - Kim, Kyung Hwan

AU - Keum, Ki Chang

AU - Noh, Sung Hoon

AU - Lim, Joon Seok

AU - Kim, Hyo Song

AU - Rha, SunYoung

AU - Lee, Yongchan

AU - Hyung, WooJin

AU - Koom, Woong Sub

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background and Objectives: To classify patients with nonmetastatic advanced gastric cancer who underwent D2-gastrectomy into prognostic groups based on peritoneal and systemic recurrence risks. Methods: Between 2004 and 2007, 1,090 patients with T3–4 or N+ gastric cancer were identified from our registry. Recurrence rates were estimated using a competing-risk analysis. Different prognostic groups were defined using recursive partitioning analysis (RPA). Results: Median follow-up was 7 years. In the RPA-model for peritoneal recurrence risk, the initial node was split by T stage, indicating that differences between patients with T1–3 and T4 cancer were the greatest. The 5-year peritoneal recurrence rates for patients with T4 (n = 627) and T1–3 (n = 463) disease were 34.3% and 9.1%, respectively. N stage and neural invasion had an additive impact on high-risk patients. The RPA model for systemic relapse incorporated N stage alone and gave two terminal nodes: N0–2 (n = 721) and N3 (n = 369). The 5-year cumulative incidences were 7.7% and 24.5%, respectively. Conclusions: We proposed risk stratification models of peritoneal and systemic recurrence in patients undergoing D2-gastrectomy. This classification could be used for stratification protocols in future studies evaluating adjuvant therapies such as preoperative chemoradiotherapy. J. Surg. Oncol. 2016;114:859–864.

AB - Background and Objectives: To classify patients with nonmetastatic advanced gastric cancer who underwent D2-gastrectomy into prognostic groups based on peritoneal and systemic recurrence risks. Methods: Between 2004 and 2007, 1,090 patients with T3–4 or N+ gastric cancer were identified from our registry. Recurrence rates were estimated using a competing-risk analysis. Different prognostic groups were defined using recursive partitioning analysis (RPA). Results: Median follow-up was 7 years. In the RPA-model for peritoneal recurrence risk, the initial node was split by T stage, indicating that differences between patients with T1–3 and T4 cancer were the greatest. The 5-year peritoneal recurrence rates for patients with T4 (n = 627) and T1–3 (n = 463) disease were 34.3% and 9.1%, respectively. N stage and neural invasion had an additive impact on high-risk patients. The RPA model for systemic relapse incorporated N stage alone and gave two terminal nodes: N0–2 (n = 721) and N3 (n = 369). The 5-year cumulative incidences were 7.7% and 24.5%, respectively. Conclusions: We proposed risk stratification models of peritoneal and systemic recurrence in patients undergoing D2-gastrectomy. This classification could be used for stratification protocols in future studies evaluating adjuvant therapies such as preoperative chemoradiotherapy. J. Surg. Oncol. 2016;114:859–864.

UR - http://www.scopus.com/inward/record.url?scp=84992467397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992467397&partnerID=8YFLogxK

U2 - 10.1002/jso.24405

DO - 10.1002/jso.24405

M3 - Article

VL - 114

SP - 859

EP - 864

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 7

ER -