Red ginseng improves exercise endurance by promoting mitochondrial biogenesis and myoblast differentiation

Eun Ju Shin, Seongin Jo, Sungbin Choi, Chang Won Cho, Won Chul Lim, Hee Do Hong, Tae Gyu Lim, Young Jin Jang, Mi Jang, Sanguine Byun, Youngkyung Rhee

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Red ginseng has been reported to elicit various therapeutic effects relevant to cancer, diabetes, neurodegenerative diseases, and inflammatory diseases. However, the effect of red ginseng on exercise endurance and skeletal muscle function remains unclear. Herein, we sought to investigate whether red ginseng could affect exercise endurance and examined its molecular mechanism. Mice were fed with red ginseng extract (RG) and undertook swimming exercises to determine the time to exhaustion. Animals fed with RG had significantly longer swimming endurance. RG treatment was also observed to enhance ATP production levels in myoblasts. RG increased mRNA expressions of mitochondrial biogenesis regulators, NRF-1, TFAM, and PGC-1α, which was accompanied by an elevation in mitochondrial DNA, suggesting an enhancement in mitochondrial energy-generating capacity. Importantly, RG treatment induced phosphorylation of p38 and AMPK and upregulated PGC1α expression in both myoblasts and in vivo muscle tissue. In addition, RG treatment also stimulated C2C12 myogenic differentiation. Our findings show that red ginseng improves exercise endurance, suggesting that it may have applications in supporting skeletal muscle function and exercise performance.

Original languageEnglish
Article number865
Issue number4
Publication statusPublished - 2020 Feb 16

Bibliographical note

Funding Information:
Funding: This work was supported by the Main Research Program (E0170700-03) of the Korea Research Food Institute (KFRI) funded by the Ministry of Science, ICT. This work was also supported by Incheon National University (20170114) funding.

Publisher Copyright:
© 2020 by the authors

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of 'Red ginseng improves exercise endurance by promoting mitochondrial biogenesis and myoblast differentiation'. Together they form a unique fingerprint.

Cite this