Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men: A randomized crossover study

Mi Hyang Lee, Jung Hyun Kwak, Gayoung Jeon, Jong Won Lee, Jang Ho Seo, Hoon Sang Lee, Jong Ho Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Heavy drinking causes hangover symptoms, because the action of alcohol dehydrogenase forms acetaldehyde, which is metabolized by acetaldehyde dehydrogenase into acetate. Red ginseng shows positive effects on alcohol metabolism in animal studies. We investigated the effects of red ginseng on relieving alcohol and hangover symptoms in 25 healthy men in a randomized crossover study. At each visit (0, 1, and 2 weeks), the subjects drank 100 mL whiskey (40% alcohol) and either 100 mL water or 100 mL of a 0.321 mg mL -1 red ginseng anti-hangover drink (RGD). We took blood samples periodically until 240 min after alcohol consumption, and we investigated the blood profiles, alcohol levels, and acetaldehyde levels. We also measured anthropometric parameters, expiratory air-alcohol levels, and hangover symptoms. The plasma alcohol concentrations within the RGD group were significantly lower than those within the placebo group after 30 min (p = 0.002), 45 min (p = 0.016), and 60 min (p = 0.009); the areas under the response curves revealed a positive effect of RGD (p = 0.051). Furthermore, the expiratory alcohol concentration was significantly lower after 30 min (p = 0.005) and 60 min (p = 0.065), and the areas under the response curves (p = 0.058) likewise revealed a positive effect of RGD. The plasma acetaldehyde level was significantly elevated at 120 min (p = 0.020), but the areas under the response curves showed a similar trend (p = 0.054). While the plasma acetaldehyde concentration slightly increased, the RGD showed positive effects on hangover symptoms. Considering the reduction of plasma alcohol levels, expiratory concentrations, and hangover severity, we conclude that red ginseng relieves the symptoms of alcohol hangover.

Original languageEnglish
Pages (from-to)528-534
Number of pages7
JournalFood and Function
Volume5
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Panax
Alcohol Drinking
Cross-Over Studies
signs and symptoms (animals and humans)
alcohols
Alcohols
Acetaldehyde
acetaldehyde
Area Under Curve
acetaldehyde dehydrogenase
whisky
cross-over studies
alcohol drinking
Alcohol Dehydrogenase
alcohol dehydrogenase
blood
Drinking
drinking
Acetates
placebos

All Science Journal Classification (ASJC) codes

  • Food Science

Cite this

Lee, Mi Hyang ; Kwak, Jung Hyun ; Jeon, Gayoung ; Lee, Jong Won ; Seo, Jang Ho ; Lee, Hoon Sang ; Lee, Jong Ho. / Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men : A randomized crossover study. In: Food and Function. 2014 ; Vol. 5, No. 3. pp. 528-534.
@article{2612db4592a343aa9511385d9be84063,
title = "Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men: A randomized crossover study",
abstract = "Heavy drinking causes hangover symptoms, because the action of alcohol dehydrogenase forms acetaldehyde, which is metabolized by acetaldehyde dehydrogenase into acetate. Red ginseng shows positive effects on alcohol metabolism in animal studies. We investigated the effects of red ginseng on relieving alcohol and hangover symptoms in 25 healthy men in a randomized crossover study. At each visit (0, 1, and 2 weeks), the subjects drank 100 mL whiskey (40{\%} alcohol) and either 100 mL water or 100 mL of a 0.321 mg mL -1 red ginseng anti-hangover drink (RGD). We took blood samples periodically until 240 min after alcohol consumption, and we investigated the blood profiles, alcohol levels, and acetaldehyde levels. We also measured anthropometric parameters, expiratory air-alcohol levels, and hangover symptoms. The plasma alcohol concentrations within the RGD group were significantly lower than those within the placebo group after 30 min (p = 0.002), 45 min (p = 0.016), and 60 min (p = 0.009); the areas under the response curves revealed a positive effect of RGD (p = 0.051). Furthermore, the expiratory alcohol concentration was significantly lower after 30 min (p = 0.005) and 60 min (p = 0.065), and the areas under the response curves (p = 0.058) likewise revealed a positive effect of RGD. The plasma acetaldehyde level was significantly elevated at 120 min (p = 0.020), but the areas under the response curves showed a similar trend (p = 0.054). While the plasma acetaldehyde concentration slightly increased, the RGD showed positive effects on hangover symptoms. Considering the reduction of plasma alcohol levels, expiratory concentrations, and hangover severity, we conclude that red ginseng relieves the symptoms of alcohol hangover.",
author = "Lee, {Mi Hyang} and Kwak, {Jung Hyun} and Gayoung Jeon and Lee, {Jong Won} and Seo, {Jang Ho} and Lee, {Hoon Sang} and Lee, {Jong Ho}",
year = "2014",
month = "1",
day = "1",
doi = "10.1039/c3fo60481k",
language = "English",
volume = "5",
pages = "528--534",
journal = "Food and Function",
issn = "2042-6496",
publisher = "Royal Society of Chemistry",
number = "3",

}

Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men : A randomized crossover study. / Lee, Mi Hyang; Kwak, Jung Hyun; Jeon, Gayoung; Lee, Jong Won; Seo, Jang Ho; Lee, Hoon Sang; Lee, Jong Ho.

In: Food and Function, Vol. 5, No. 3, 01.01.2014, p. 528-534.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men

T2 - A randomized crossover study

AU - Lee, Mi Hyang

AU - Kwak, Jung Hyun

AU - Jeon, Gayoung

AU - Lee, Jong Won

AU - Seo, Jang Ho

AU - Lee, Hoon Sang

AU - Lee, Jong Ho

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Heavy drinking causes hangover symptoms, because the action of alcohol dehydrogenase forms acetaldehyde, which is metabolized by acetaldehyde dehydrogenase into acetate. Red ginseng shows positive effects on alcohol metabolism in animal studies. We investigated the effects of red ginseng on relieving alcohol and hangover symptoms in 25 healthy men in a randomized crossover study. At each visit (0, 1, and 2 weeks), the subjects drank 100 mL whiskey (40% alcohol) and either 100 mL water or 100 mL of a 0.321 mg mL -1 red ginseng anti-hangover drink (RGD). We took blood samples periodically until 240 min after alcohol consumption, and we investigated the blood profiles, alcohol levels, and acetaldehyde levels. We also measured anthropometric parameters, expiratory air-alcohol levels, and hangover symptoms. The plasma alcohol concentrations within the RGD group were significantly lower than those within the placebo group after 30 min (p = 0.002), 45 min (p = 0.016), and 60 min (p = 0.009); the areas under the response curves revealed a positive effect of RGD (p = 0.051). Furthermore, the expiratory alcohol concentration was significantly lower after 30 min (p = 0.005) and 60 min (p = 0.065), and the areas under the response curves (p = 0.058) likewise revealed a positive effect of RGD. The plasma acetaldehyde level was significantly elevated at 120 min (p = 0.020), but the areas under the response curves showed a similar trend (p = 0.054). While the plasma acetaldehyde concentration slightly increased, the RGD showed positive effects on hangover symptoms. Considering the reduction of plasma alcohol levels, expiratory concentrations, and hangover severity, we conclude that red ginseng relieves the symptoms of alcohol hangover.

AB - Heavy drinking causes hangover symptoms, because the action of alcohol dehydrogenase forms acetaldehyde, which is metabolized by acetaldehyde dehydrogenase into acetate. Red ginseng shows positive effects on alcohol metabolism in animal studies. We investigated the effects of red ginseng on relieving alcohol and hangover symptoms in 25 healthy men in a randomized crossover study. At each visit (0, 1, and 2 weeks), the subjects drank 100 mL whiskey (40% alcohol) and either 100 mL water or 100 mL of a 0.321 mg mL -1 red ginseng anti-hangover drink (RGD). We took blood samples periodically until 240 min after alcohol consumption, and we investigated the blood profiles, alcohol levels, and acetaldehyde levels. We also measured anthropometric parameters, expiratory air-alcohol levels, and hangover symptoms. The plasma alcohol concentrations within the RGD group were significantly lower than those within the placebo group after 30 min (p = 0.002), 45 min (p = 0.016), and 60 min (p = 0.009); the areas under the response curves revealed a positive effect of RGD (p = 0.051). Furthermore, the expiratory alcohol concentration was significantly lower after 30 min (p = 0.005) and 60 min (p = 0.065), and the areas under the response curves (p = 0.058) likewise revealed a positive effect of RGD. The plasma acetaldehyde level was significantly elevated at 120 min (p = 0.020), but the areas under the response curves showed a similar trend (p = 0.054). While the plasma acetaldehyde concentration slightly increased, the RGD showed positive effects on hangover symptoms. Considering the reduction of plasma alcohol levels, expiratory concentrations, and hangover severity, we conclude that red ginseng relieves the symptoms of alcohol hangover.

UR - http://www.scopus.com/inward/record.url?scp=84896831200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896831200&partnerID=8YFLogxK

U2 - 10.1039/c3fo60481k

DO - 10.1039/c3fo60481k

M3 - Article

C2 - 24458173

AN - SCOPUS:84896831200

VL - 5

SP - 528

EP - 534

JO - Food and Function

JF - Food and Function

SN - 2042-6496

IS - 3

ER -