Redox signaling by ionizing radiation in mouse liver

Jeung Hee An, Jiyoung Kim, Jinsil Seong

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Since radiation treatment has been reappraised in the treatment of hepatic tumors, radiation response in the liver is emerging as an interesting new area of investigation. In this study, identification of the repertoire of signaling proteins was performed using a proteomics approach involving cellular responses of liver tissue to ionizing radiation. Approximately 800 protein spots were detected. Among them, at least 28 proteins showed significant quantitative alterations after radiation. The significantly altered proteins were categorized as those related to reactive oxygen species (ROS) metabolism, metabolic pathway proteins, and G-type proteins. Particularly, the expression levels of proteins related to ROS metabolism, including cytochrome c, glutathione S-transferase Pi, NADH dehydrogenase, and peroxiredoxin VI, were increased after radiation. It is suggested that although radiation initiates cytotoxic effects, it can also induce a radioprotective antioxidant system.

Original languageEnglish
Pages (from-to)86-94
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume1030
DOIs
Publication statusPublished - 2004 Jan 1

Fingerprint

Ionizing radiation
Ionizing Radiation
Liver
Oxidation-Reduction
Radiation
Proteins
Metabolism
Reactive Oxygen Species
Peroxiredoxin VI
Glutathione S-Transferase pi
NADH Dehydrogenase
Metabolic Networks and Pathways
Cytochromes c
GTP-Binding Proteins
Proteomics
Protein
Mouse
Tumors
Antioxidants
Tissue

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

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Redox signaling by ionizing radiation in mouse liver. / An, Jeung Hee; Kim, Jiyoung; Seong, Jinsil.

In: Annals of the New York Academy of Sciences, Vol. 1030, 01.01.2004, p. 86-94.

Research output: Contribution to journalArticle

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