Redoxable heteronanocrystals functioning magnetic relaxation switch for activatable T1 and T2 dual-mode magnetic resonance imaging

Myeong Hoon Kim, Hye Young Son, Ga Yun Kim, Kwangyeol Park, yongmin Huh, Seungjoo Haam

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

T1/T2 dual-mode magnetic resonance (MR) contrast agents (DMCAs) have gained much attention because of their ability to improve accuracy by providing two pieces of complementary information with one instrument. However, most of these agents are "always ON" systems that emit MR contrast regardless of their interaction with target cells or biomarkers, which may result in poor target-to-background ratios. Herein, we introduce a rationally designed magnetic relaxation switch (MGRS) for an activatable T1/T2 dual MR imaging system. Redox-responsive heteronanocrystals, consisting of a superparamagnetic Fe3O4 core and a paramagnetic Mn3O4 shell, are synthesized through seed-mediated growth and subsequently surface-modified with polysorbate 80. The Mn3O4 shell acts as both a protector of Fe3O4 in aqueous environments to attenuate T2 relaxation and as a redoxable switch that can be activated in intracellular reducing environments by glutathione. This simultaneously generates large amounts of magnetically decoupled Mn2+ ions and allows Fe3O4 to interact with the water protons. This smart nanoplatform shows an appropriate hydrodynamic size for the EPR effect (10-100 nm) and demonstrates biocompatibility. Efficient transitions of OFF/ON dual contrast effects are observed by in vitro imaging and MR relaxivity measurements. The ability to use these materials as DMCAs is demonstrated via effective passive tumor targeting for T1- and T2-weighted MR imaging in tumor-bearing mice.

Original languageEnglish
Pages (from-to)121-130
Number of pages10
JournalBiomaterials
Volume101
DOIs
Publication statusPublished - 2016 Sep 1

Fingerprint

Magnetic relaxation
Magnetic resonance
Switches
Magnetic Resonance Imaging
Imaging techniques
Magnetic Resonance Spectroscopy
Tumors
Bearings (structural)
Polysorbates
Magnetic resonance measurement
Hydrodynamics
Contrast Media
Oxidation-Reduction
Glutathione
Protons
Neoplasms
Seeds
Biomarkers
Biocompatibility
Imaging systems

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

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abstract = "T1/T2 dual-mode magnetic resonance (MR) contrast agents (DMCAs) have gained much attention because of their ability to improve accuracy by providing two pieces of complementary information with one instrument. However, most of these agents are {"}always ON{"} systems that emit MR contrast regardless of their interaction with target cells or biomarkers, which may result in poor target-to-background ratios. Herein, we introduce a rationally designed magnetic relaxation switch (MGRS) for an activatable T1/T2 dual MR imaging system. Redox-responsive heteronanocrystals, consisting of a superparamagnetic Fe3O4 core and a paramagnetic Mn3O4 shell, are synthesized through seed-mediated growth and subsequently surface-modified with polysorbate 80. The Mn3O4 shell acts as both a protector of Fe3O4 in aqueous environments to attenuate T2 relaxation and as a redoxable switch that can be activated in intracellular reducing environments by glutathione. This simultaneously generates large amounts of magnetically decoupled Mn2+ ions and allows Fe3O4 to interact with the water protons. This smart nanoplatform shows an appropriate hydrodynamic size for the EPR effect (10-100 nm) and demonstrates biocompatibility. Efficient transitions of OFF/ON dual contrast effects are observed by in vitro imaging and MR relaxivity measurements. The ability to use these materials as DMCAs is demonstrated via effective passive tumor targeting for T1- and T2-weighted MR imaging in tumor-bearing mice.",
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Redoxable heteronanocrystals functioning magnetic relaxation switch for activatable T1 and T2 dual-mode magnetic resonance imaging. / Kim, Myeong Hoon; Son, Hye Young; Kim, Ga Yun; Park, Kwangyeol; Huh, yongmin; Haam, Seungjoo.

In: Biomaterials, Vol. 101, 01.09.2016, p. 121-130.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Redoxable heteronanocrystals functioning magnetic relaxation switch for activatable T1 and T2 dual-mode magnetic resonance imaging

AU - Kim, Myeong Hoon

AU - Son, Hye Young

AU - Kim, Ga Yun

AU - Park, Kwangyeol

AU - Huh, yongmin

AU - Haam, Seungjoo

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