Reduced P300 amplitude during a visuospatial attention task in idiopathic rapid eye movement sleep behavior disorder

Jung Ick Byun, Byeong Uk Lee, Minah Kim, Jun Sang Sunwoo, Jung Ah Lim, Jangsup Moon, Soon Tae Lee, Keun Hwa Jung, Kon Chu, Man Ho Kim, Min Hee Jeong, Kwang Su Cha, Jeong Woo Choi, Kyunghwan Kim, Sang Kun Lee, Ki Young Jung

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Abstract

Objectives Idiopathic rapid eye movement sleep behavior disorder (IRBD) patients are prone to cognitive deficits, which include attention, executive, and visuospatial dysfunctions. Even patients with normal cognition may exhibit subclinical electrophysiological dysfunction. This study aimed to evaluate visuospatial attention processing in IRBD patients with normal cognition and to compare their findings with those of age- and sex-matched healthy controls. Methods We recorded event-related potentials (ERPs) and performance measures during a variant of the Posner task in 14 IRBD patients and 14 control subjects. Behavioral data and the mean P300 amplitude were compared between groups. Results No group difference was found for reaction time or accuracy, but a significant group effect was observed for the P300 amplitude. IRBD patients had reduced P300 amplitude (μV) than controls in both valid (IRBD: 0.53 ± 1.05 vs Controls: 1.61 ± 0.95; p = 0.008) and invalid (IRBD: 0.74 ± 0.99 vs Controls: 1.73 ± 0.86; p = 0.009) conditions. The P300 amplitude was correlated with Montreal cognitive assessment (MOCA) scores (r = 0.424, p = 0.024). Conclusion Reduced P300 amplitude during the Posner task provides electrophysiological evidence for subclinical visuospatial attention deficits in cognitively normal IRBD patients. The results of this study imply that cortical dysfunction is already present in patients with IRBD in their early disease stage.

Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalSleep Medicine
Volume38
DOIs
Publication statusPublished - 2017 Oct 1

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REM Sleep Behavior Disorder
Cognition
Evoked Potentials
Reaction Time

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Byun, Jung Ick ; Lee, Byeong Uk ; Kim, Minah ; Sunwoo, Jun Sang ; Lim, Jung Ah ; Moon, Jangsup ; Lee, Soon Tae ; Jung, Keun Hwa ; Chu, Kon ; Kim, Man Ho ; Jeong, Min Hee ; Cha, Kwang Su ; Choi, Jeong Woo ; Kim, Kyunghwan ; Lee, Sang Kun ; Jung, Ki Young. / Reduced P300 amplitude during a visuospatial attention task in idiopathic rapid eye movement sleep behavior disorder. In: Sleep Medicine. 2017 ; Vol. 38. pp. 78-84.
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title = "Reduced P300 amplitude during a visuospatial attention task in idiopathic rapid eye movement sleep behavior disorder",
abstract = "Objectives Idiopathic rapid eye movement sleep behavior disorder (IRBD) patients are prone to cognitive deficits, which include attention, executive, and visuospatial dysfunctions. Even patients with normal cognition may exhibit subclinical electrophysiological dysfunction. This study aimed to evaluate visuospatial attention processing in IRBD patients with normal cognition and to compare their findings with those of age- and sex-matched healthy controls. Methods We recorded event-related potentials (ERPs) and performance measures during a variant of the Posner task in 14 IRBD patients and 14 control subjects. Behavioral data and the mean P300 amplitude were compared between groups. Results No group difference was found for reaction time or accuracy, but a significant group effect was observed for the P300 amplitude. IRBD patients had reduced P300 amplitude (μV) than controls in both valid (IRBD: 0.53 ± 1.05 vs Controls: 1.61 ± 0.95; p = 0.008) and invalid (IRBD: 0.74 ± 0.99 vs Controls: 1.73 ± 0.86; p = 0.009) conditions. The P300 amplitude was correlated with Montreal cognitive assessment (MOCA) scores (r = 0.424, p = 0.024). Conclusion Reduced P300 amplitude during the Posner task provides electrophysiological evidence for subclinical visuospatial attention deficits in cognitively normal IRBD patients. The results of this study imply that cortical dysfunction is already present in patients with IRBD in their early disease stage.",
author = "Byun, {Jung Ick} and Lee, {Byeong Uk} and Minah Kim and Sunwoo, {Jun Sang} and Lim, {Jung Ah} and Jangsup Moon and Lee, {Soon Tae} and Jung, {Keun Hwa} and Kon Chu and Kim, {Man Ho} and Jeong, {Min Hee} and Cha, {Kwang Su} and Choi, {Jeong Woo} and Kyunghwan Kim and Lee, {Sang Kun} and Jung, {Ki Young}",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.sleep.2017.06.037",
language = "English",
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journal = "Sleep Medicine",
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Byun, JI, Lee, BU, Kim, M, Sunwoo, JS, Lim, JA, Moon, J, Lee, ST, Jung, KH, Chu, K, Kim, MH, Jeong, MH, Cha, KS, Choi, JW, Kim, K, Lee, SK & Jung, KY 2017, 'Reduced P300 amplitude during a visuospatial attention task in idiopathic rapid eye movement sleep behavior disorder', Sleep Medicine, vol. 38, pp. 78-84. https://doi.org/10.1016/j.sleep.2017.06.037

Reduced P300 amplitude during a visuospatial attention task in idiopathic rapid eye movement sleep behavior disorder. / Byun, Jung Ick; Lee, Byeong Uk; Kim, Minah; Sunwoo, Jun Sang; Lim, Jung Ah; Moon, Jangsup; Lee, Soon Tae; Jung, Keun Hwa; Chu, Kon; Kim, Man Ho; Jeong, Min Hee; Cha, Kwang Su; Choi, Jeong Woo; Kim, Kyunghwan; Lee, Sang Kun; Jung, Ki Young.

In: Sleep Medicine, Vol. 38, 01.10.2017, p. 78-84.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Reduced P300 amplitude during a visuospatial attention task in idiopathic rapid eye movement sleep behavior disorder

AU - Byun, Jung Ick

AU - Lee, Byeong Uk

AU - Kim, Minah

AU - Sunwoo, Jun Sang

AU - Lim, Jung Ah

AU - Moon, Jangsup

AU - Lee, Soon Tae

AU - Jung, Keun Hwa

AU - Chu, Kon

AU - Kim, Man Ho

AU - Jeong, Min Hee

AU - Cha, Kwang Su

AU - Choi, Jeong Woo

AU - Kim, Kyunghwan

AU - Lee, Sang Kun

AU - Jung, Ki Young

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Objectives Idiopathic rapid eye movement sleep behavior disorder (IRBD) patients are prone to cognitive deficits, which include attention, executive, and visuospatial dysfunctions. Even patients with normal cognition may exhibit subclinical electrophysiological dysfunction. This study aimed to evaluate visuospatial attention processing in IRBD patients with normal cognition and to compare their findings with those of age- and sex-matched healthy controls. Methods We recorded event-related potentials (ERPs) and performance measures during a variant of the Posner task in 14 IRBD patients and 14 control subjects. Behavioral data and the mean P300 amplitude were compared between groups. Results No group difference was found for reaction time or accuracy, but a significant group effect was observed for the P300 amplitude. IRBD patients had reduced P300 amplitude (μV) than controls in both valid (IRBD: 0.53 ± 1.05 vs Controls: 1.61 ± 0.95; p = 0.008) and invalid (IRBD: 0.74 ± 0.99 vs Controls: 1.73 ± 0.86; p = 0.009) conditions. The P300 amplitude was correlated with Montreal cognitive assessment (MOCA) scores (r = 0.424, p = 0.024). Conclusion Reduced P300 amplitude during the Posner task provides electrophysiological evidence for subclinical visuospatial attention deficits in cognitively normal IRBD patients. The results of this study imply that cortical dysfunction is already present in patients with IRBD in their early disease stage.

AB - Objectives Idiopathic rapid eye movement sleep behavior disorder (IRBD) patients are prone to cognitive deficits, which include attention, executive, and visuospatial dysfunctions. Even patients with normal cognition may exhibit subclinical electrophysiological dysfunction. This study aimed to evaluate visuospatial attention processing in IRBD patients with normal cognition and to compare their findings with those of age- and sex-matched healthy controls. Methods We recorded event-related potentials (ERPs) and performance measures during a variant of the Posner task in 14 IRBD patients and 14 control subjects. Behavioral data and the mean P300 amplitude were compared between groups. Results No group difference was found for reaction time or accuracy, but a significant group effect was observed for the P300 amplitude. IRBD patients had reduced P300 amplitude (μV) than controls in both valid (IRBD: 0.53 ± 1.05 vs Controls: 1.61 ± 0.95; p = 0.008) and invalid (IRBD: 0.74 ± 0.99 vs Controls: 1.73 ± 0.86; p = 0.009) conditions. The P300 amplitude was correlated with Montreal cognitive assessment (MOCA) scores (r = 0.424, p = 0.024). Conclusion Reduced P300 amplitude during the Posner task provides electrophysiological evidence for subclinical visuospatial attention deficits in cognitively normal IRBD patients. The results of this study imply that cortical dysfunction is already present in patients with IRBD in their early disease stage.

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