Reduced serum total osteocalcin is associated with central obesity in Korean children

Gwangsuk Kim, Yoonsuk Jekal, Hee Soon Kim, Jee Aee Im, Ji Young Park, Sang Hui Chu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Recently, osteocalcin (OC), an osteoblast-derived hormone, has been suggested as a new link between obesity and insulin resistance in humans. However, few studies regarding the relationship between OC and obesity in Asian children have been published. We investigated the association of OC with adiposity, insulin resistance and metabolic syndrome (MetS) in Korean children. Methods: Two hundred and nine (100 boys, 109 girls) children (age: 9.78 ± 1.05 years, body mass index (BMI): 22.27 ± 5.34 kg/m2) participated in this cross-sectional study. Anthropometric parameters, insulin resistance, lipid profiles, total OC, and an inflammatory marker, C-reactive protein (CRP), were measured. MetS phenotype was also determined. Results: Serum total OC levels were significantly lower in overweight or obese children (76.96 ± 27.08 ng/ml vs. 66.91 ± 21.39 ng/ml, p = 0.020) and it was negatively associated with body fat after controlling for age, gender and BMI. Serum total OC concentrations were significantly lower in participants with central obesity or at least two components of MetS driven by waist circumference than they were in those with none. Stepwise linear regression results also showed that serum total OC was partially explained by age, gender, waist-to-hip ratio, and fasting glucose. Conclusions: This study supported a negative association between serum total OC and adiposity in children. OC may be associated with childhood central obesity; however, further research using more accurate measurements is needed to identify the association between these variables.

Original languageEnglish
JournalObesity Research and Clinical Practice
Volume8
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Abdominal Obesity
Osteocalcin
Serum
Insulin Resistance
Adiposity
Body Mass Index
Obesity
Waist-Hip Ratio
Pediatric Obesity
Waist Circumference
Osteoblasts
C-Reactive Protein
Adipose Tissue
Linear Models
Fasting
Cross-Sectional Studies
Hormones
Phenotype
Lipids
Glucose

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

@article{f5c5c2aec0f6499d805e4695febf9d1c,
title = "Reduced serum total osteocalcin is associated with central obesity in Korean children",
abstract = "Background: Recently, osteocalcin (OC), an osteoblast-derived hormone, has been suggested as a new link between obesity and insulin resistance in humans. However, few studies regarding the relationship between OC and obesity in Asian children have been published. We investigated the association of OC with adiposity, insulin resistance and metabolic syndrome (MetS) in Korean children. Methods: Two hundred and nine (100 boys, 109 girls) children (age: 9.78 ± 1.05 years, body mass index (BMI): 22.27 ± 5.34 kg/m2) participated in this cross-sectional study. Anthropometric parameters, insulin resistance, lipid profiles, total OC, and an inflammatory marker, C-reactive protein (CRP), were measured. MetS phenotype was also determined. Results: Serum total OC levels were significantly lower in overweight or obese children (76.96 ± 27.08 ng/ml vs. 66.91 ± 21.39 ng/ml, p = 0.020) and it was negatively associated with body fat after controlling for age, gender and BMI. Serum total OC concentrations were significantly lower in participants with central obesity or at least two components of MetS driven by waist circumference than they were in those with none. Stepwise linear regression results also showed that serum total OC was partially explained by age, gender, waist-to-hip ratio, and fasting glucose. Conclusions: This study supported a negative association between serum total OC and adiposity in children. OC may be associated with childhood central obesity; however, further research using more accurate measurements is needed to identify the association between these variables.",
author = "Gwangsuk Kim and Yoonsuk Jekal and Kim, {Hee Soon} and Im, {Jee Aee} and Park, {Ji Young} and Chu, {Sang Hui}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.orcp.2012.12.003",
language = "English",
volume = "8",
journal = "Obesity Research and Clinical Practice",
issn = "1871-403X",
publisher = "Elsevier BV",
number = "3",

}

Reduced serum total osteocalcin is associated with central obesity in Korean children. / Kim, Gwangsuk; Jekal, Yoonsuk; Kim, Hee Soon; Im, Jee Aee; Park, Ji Young; Chu, Sang Hui.

In: Obesity Research and Clinical Practice, Vol. 8, No. 3, 01.01.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Reduced serum total osteocalcin is associated with central obesity in Korean children

AU - Kim, Gwangsuk

AU - Jekal, Yoonsuk

AU - Kim, Hee Soon

AU - Im, Jee Aee

AU - Park, Ji Young

AU - Chu, Sang Hui

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Recently, osteocalcin (OC), an osteoblast-derived hormone, has been suggested as a new link between obesity and insulin resistance in humans. However, few studies regarding the relationship between OC and obesity in Asian children have been published. We investigated the association of OC with adiposity, insulin resistance and metabolic syndrome (MetS) in Korean children. Methods: Two hundred and nine (100 boys, 109 girls) children (age: 9.78 ± 1.05 years, body mass index (BMI): 22.27 ± 5.34 kg/m2) participated in this cross-sectional study. Anthropometric parameters, insulin resistance, lipid profiles, total OC, and an inflammatory marker, C-reactive protein (CRP), were measured. MetS phenotype was also determined. Results: Serum total OC levels were significantly lower in overweight or obese children (76.96 ± 27.08 ng/ml vs. 66.91 ± 21.39 ng/ml, p = 0.020) and it was negatively associated with body fat after controlling for age, gender and BMI. Serum total OC concentrations were significantly lower in participants with central obesity or at least two components of MetS driven by waist circumference than they were in those with none. Stepwise linear regression results also showed that serum total OC was partially explained by age, gender, waist-to-hip ratio, and fasting glucose. Conclusions: This study supported a negative association between serum total OC and adiposity in children. OC may be associated with childhood central obesity; however, further research using more accurate measurements is needed to identify the association between these variables.

AB - Background: Recently, osteocalcin (OC), an osteoblast-derived hormone, has been suggested as a new link between obesity and insulin resistance in humans. However, few studies regarding the relationship between OC and obesity in Asian children have been published. We investigated the association of OC with adiposity, insulin resistance and metabolic syndrome (MetS) in Korean children. Methods: Two hundred and nine (100 boys, 109 girls) children (age: 9.78 ± 1.05 years, body mass index (BMI): 22.27 ± 5.34 kg/m2) participated in this cross-sectional study. Anthropometric parameters, insulin resistance, lipid profiles, total OC, and an inflammatory marker, C-reactive protein (CRP), were measured. MetS phenotype was also determined. Results: Serum total OC levels were significantly lower in overweight or obese children (76.96 ± 27.08 ng/ml vs. 66.91 ± 21.39 ng/ml, p = 0.020) and it was negatively associated with body fat after controlling for age, gender and BMI. Serum total OC concentrations were significantly lower in participants with central obesity or at least two components of MetS driven by waist circumference than they were in those with none. Stepwise linear regression results also showed that serum total OC was partially explained by age, gender, waist-to-hip ratio, and fasting glucose. Conclusions: This study supported a negative association between serum total OC and adiposity in children. OC may be associated with childhood central obesity; however, further research using more accurate measurements is needed to identify the association between these variables.

UR - http://www.scopus.com/inward/record.url?scp=84900515052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900515052&partnerID=8YFLogxK

U2 - 10.1016/j.orcp.2012.12.003

DO - 10.1016/j.orcp.2012.12.003

M3 - Article

C2 - 24847664

AN - SCOPUS:84900515052

VL - 8

JO - Obesity Research and Clinical Practice

JF - Obesity Research and Clinical Practice

SN - 1871-403X

IS - 3

ER -