TY - JOUR
T1 - Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification
AU - Lee, Mi Kyung
AU - Jekal, Yoonsuk
AU - Im, Jee Aee
AU - Kim, Eunsung
AU - Lee, Seung Hwan
AU - Park, Ji Hye
AU - Chu, Sang Hui
AU - Chung, Kyong Mee
AU - Lee, Hyun Chul
AU - Oh, Eui Geum
AU - Kim, Sang Hwan
AU - Jeon, Justin Y.
N1 - Funding Information:
This work was supported in part by the Korean Research Foundation ( KRF 332-2006-B00450 ) and Sports ToTo .
PY - 2010/3/2
Y1 - 2010/3/2
N2 - Background: Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a potential insulin sensitizing adipokine, however, the factors determining the levels of circulating vaspin levels have not been fully understood. We investigated the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, and the effects of short-term intensive lifestyle modification on circulating vaspin levels in overweight or obese children. Methods: A total of 50 (25 boys, 25 girls) overweight or obese children aged 11 to 13 years (average age: 12.0 ± 0.9 y, BMI: 25.35 ± 86 kg/m2) who complied with inclusion criteria participated in our study. To determine the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, cross-sectional analyses were performed. Thereafter, subjects underwent a tightly controlled seven-day intensive lifestyle modification including physical activity, dietary modification, and behavioral modification education in residence of a local university dormitory. Results: There was a negative correlation between vaspin concentration and fasting insulin (r = -.325, p < 0.05) and homeostasis model assessment of insulin resistance (HOMA-IR) (r = -.331, p < 0.05) when percent body fat was controlled. Multivariate linear regression analysis found serum vaspin level to be an independent predictor of insulin and HOMA-IR. Short-term intensive lifestyle modification significantly decreased vaspin levels by 39.28% (pre: .84 ± 1.0, post: .51 ± 1.0 ng/ml, p < 0.001) while adiponectin levels increased by 11.2% (pre: 6.50 ± 2.89, post: 7.28 ± 2.98 ng/ml, p < 0.01). In addition, short-term lifestyle modification significantly improved HOMA-IR (pre: 3.58 ± 1.93, post 1.30 ± 1.9, p < 0.001) and lipid profiles. Conclusions: Serum vaspin level is one of the predictors for insulin resistance and was significantly reduced following short-term lifestyle modification.
AB - Background: Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a potential insulin sensitizing adipokine, however, the factors determining the levels of circulating vaspin levels have not been fully understood. We investigated the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, and the effects of short-term intensive lifestyle modification on circulating vaspin levels in overweight or obese children. Methods: A total of 50 (25 boys, 25 girls) overweight or obese children aged 11 to 13 years (average age: 12.0 ± 0.9 y, BMI: 25.35 ± 86 kg/m2) who complied with inclusion criteria participated in our study. To determine the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, cross-sectional analyses were performed. Thereafter, subjects underwent a tightly controlled seven-day intensive lifestyle modification including physical activity, dietary modification, and behavioral modification education in residence of a local university dormitory. Results: There was a negative correlation between vaspin concentration and fasting insulin (r = -.325, p < 0.05) and homeostasis model assessment of insulin resistance (HOMA-IR) (r = -.331, p < 0.05) when percent body fat was controlled. Multivariate linear regression analysis found serum vaspin level to be an independent predictor of insulin and HOMA-IR. Short-term intensive lifestyle modification significantly decreased vaspin levels by 39.28% (pre: .84 ± 1.0, post: .51 ± 1.0 ng/ml, p < 0.001) while adiponectin levels increased by 11.2% (pre: 6.50 ± 2.89, post: 7.28 ± 2.98 ng/ml, p < 0.01). In addition, short-term lifestyle modification significantly improved HOMA-IR (pre: 3.58 ± 1.93, post 1.30 ± 1.9, p < 0.001) and lipid profiles. Conclusions: Serum vaspin level is one of the predictors for insulin resistance and was significantly reduced following short-term lifestyle modification.
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U2 - 10.1016/j.cca.2009.12.003
DO - 10.1016/j.cca.2009.12.003
M3 - Article
C2 - 20018186
AN - SCOPUS:74849133692
SN - 0009-8981
VL - 411
SP - 381
EP - 385
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 5-6
ER -