Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification

Mi Kyung Lee, Yoonsuk Jekal, Jee Aee Im, Eunsung Kim, Seung Hwan Lee, Ji Hye Park, Sang Hui Chu, Kyongmee Chung, Hyun Chul Lee, Euigeum Oh, Sang Hwan Kim, Justin Y. Jeon

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a potential insulin sensitizing adipokine, however, the factors determining the levels of circulating vaspin levels have not been fully understood. We investigated the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, and the effects of short-term intensive lifestyle modification on circulating vaspin levels in overweight or obese children. Methods: A total of 50 (25 boys, 25 girls) overweight or obese children aged 11 to 13 years (average age: 12.0 ± 0.9 y, BMI: 25.35 ± 86 kg/m 2 ) who complied with inclusion criteria participated in our study. To determine the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, cross-sectional analyses were performed. Thereafter, subjects underwent a tightly controlled seven-day intensive lifestyle modification including physical activity, dietary modification, and behavioral modification education in residence of a local university dormitory. Results: There was a negative correlation between vaspin concentration and fasting insulin (r = -.325, p < 0.05) and homeostasis model assessment of insulin resistance (HOMA-IR) (r = -.331, p < 0.05) when percent body fat was controlled. Multivariate linear regression analysis found serum vaspin level to be an independent predictor of insulin and HOMA-IR. Short-term intensive lifestyle modification significantly decreased vaspin levels by 39.28% (pre: .84 ± 1.0, post: .51 ± 1.0 ng/ml, p < 0.001) while adiponectin levels increased by 11.2% (pre: 6.50 ± 2.89, post: 7.28 ± 2.98 ng/ml, p < 0.01). In addition, short-term lifestyle modification significantly improved HOMA-IR (pre: 3.58 ± 1.93, post 1.30 ± 1.9, p < 0.001) and lipid profiles. Conclusions: Serum vaspin level is one of the predictors for insulin resistance and was significantly reduced following short-term lifestyle modification.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalClinica Chimica Acta
Volume411
Issue number5-6
DOIs
Publication statusPublished - 2010 Mar 2

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Serpins
Intra-Abdominal Fat
Life Style
Insulin
Tissue
Insulin Resistance
Serum
Homeostasis
Adiposity
Lipids
Diet Therapy
Adipokines
Adiponectin
Linear regression
Regression analysis
Adipose Tissue
Linear Models
Fasting
Cross-Sectional Studies
Education

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Lee, Mi Kyung ; Jekal, Yoonsuk ; Im, Jee Aee ; Kim, Eunsung ; Lee, Seung Hwan ; Park, Ji Hye ; Chu, Sang Hui ; Chung, Kyongmee ; Lee, Hyun Chul ; Oh, Euigeum ; Kim, Sang Hwan ; Jeon, Justin Y. / Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification. In: Clinica Chimica Acta. 2010 ; Vol. 411, No. 5-6. pp. 381-385.
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abstract = "Background: Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a potential insulin sensitizing adipokine, however, the factors determining the levels of circulating vaspin levels have not been fully understood. We investigated the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, and the effects of short-term intensive lifestyle modification on circulating vaspin levels in overweight or obese children. Methods: A total of 50 (25 boys, 25 girls) overweight or obese children aged 11 to 13 years (average age: 12.0 ± 0.9 y, BMI: 25.35 ± 86 kg/m 2 ) who complied with inclusion criteria participated in our study. To determine the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, cross-sectional analyses were performed. Thereafter, subjects underwent a tightly controlled seven-day intensive lifestyle modification including physical activity, dietary modification, and behavioral modification education in residence of a local university dormitory. Results: There was a negative correlation between vaspin concentration and fasting insulin (r = -.325, p < 0.05) and homeostasis model assessment of insulin resistance (HOMA-IR) (r = -.331, p < 0.05) when percent body fat was controlled. Multivariate linear regression analysis found serum vaspin level to be an independent predictor of insulin and HOMA-IR. Short-term intensive lifestyle modification significantly decreased vaspin levels by 39.28{\%} (pre: .84 ± 1.0, post: .51 ± 1.0 ng/ml, p < 0.001) while adiponectin levels increased by 11.2{\%} (pre: 6.50 ± 2.89, post: 7.28 ± 2.98 ng/ml, p < 0.01). In addition, short-term lifestyle modification significantly improved HOMA-IR (pre: 3.58 ± 1.93, post 1.30 ± 1.9, p < 0.001) and lipid profiles. Conclusions: Serum vaspin level is one of the predictors for insulin resistance and was significantly reduced following short-term lifestyle modification.",
author = "Lee, {Mi Kyung} and Yoonsuk Jekal and Im, {Jee Aee} and Eunsung Kim and Lee, {Seung Hwan} and Park, {Ji Hye} and Chu, {Sang Hui} and Kyongmee Chung and Lee, {Hyun Chul} and Euigeum Oh and Kim, {Sang Hwan} and Jeon, {Justin Y.}",
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Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification. / Lee, Mi Kyung; Jekal, Yoonsuk; Im, Jee Aee; Kim, Eunsung; Lee, Seung Hwan; Park, Ji Hye; Chu, Sang Hui; Chung, Kyongmee; Lee, Hyun Chul; Oh, Euigeum; Kim, Sang Hwan; Jeon, Justin Y.

In: Clinica Chimica Acta, Vol. 411, No. 5-6, 02.03.2010, p. 381-385.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification

AU - Lee, Mi Kyung

AU - Jekal, Yoonsuk

AU - Im, Jee Aee

AU - Kim, Eunsung

AU - Lee, Seung Hwan

AU - Park, Ji Hye

AU - Chu, Sang Hui

AU - Chung, Kyongmee

AU - Lee, Hyun Chul

AU - Oh, Euigeum

AU - Kim, Sang Hwan

AU - Jeon, Justin Y.

PY - 2010/3/2

Y1 - 2010/3/2

N2 - Background: Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a potential insulin sensitizing adipokine, however, the factors determining the levels of circulating vaspin levels have not been fully understood. We investigated the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, and the effects of short-term intensive lifestyle modification on circulating vaspin levels in overweight or obese children. Methods: A total of 50 (25 boys, 25 girls) overweight or obese children aged 11 to 13 years (average age: 12.0 ± 0.9 y, BMI: 25.35 ± 86 kg/m 2 ) who complied with inclusion criteria participated in our study. To determine the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, cross-sectional analyses were performed. Thereafter, subjects underwent a tightly controlled seven-day intensive lifestyle modification including physical activity, dietary modification, and behavioral modification education in residence of a local university dormitory. Results: There was a negative correlation between vaspin concentration and fasting insulin (r = -.325, p < 0.05) and homeostasis model assessment of insulin resistance (HOMA-IR) (r = -.331, p < 0.05) when percent body fat was controlled. Multivariate linear regression analysis found serum vaspin level to be an independent predictor of insulin and HOMA-IR. Short-term intensive lifestyle modification significantly decreased vaspin levels by 39.28% (pre: .84 ± 1.0, post: .51 ± 1.0 ng/ml, p < 0.001) while adiponectin levels increased by 11.2% (pre: 6.50 ± 2.89, post: 7.28 ± 2.98 ng/ml, p < 0.01). In addition, short-term lifestyle modification significantly improved HOMA-IR (pre: 3.58 ± 1.93, post 1.30 ± 1.9, p < 0.001) and lipid profiles. Conclusions: Serum vaspin level is one of the predictors for insulin resistance and was significantly reduced following short-term lifestyle modification.

AB - Background: Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a potential insulin sensitizing adipokine, however, the factors determining the levels of circulating vaspin levels have not been fully understood. We investigated the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, and the effects of short-term intensive lifestyle modification on circulating vaspin levels in overweight or obese children. Methods: A total of 50 (25 boys, 25 girls) overweight or obese children aged 11 to 13 years (average age: 12.0 ± 0.9 y, BMI: 25.35 ± 86 kg/m 2 ) who complied with inclusion criteria participated in our study. To determine the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, cross-sectional analyses were performed. Thereafter, subjects underwent a tightly controlled seven-day intensive lifestyle modification including physical activity, dietary modification, and behavioral modification education in residence of a local university dormitory. Results: There was a negative correlation between vaspin concentration and fasting insulin (r = -.325, p < 0.05) and homeostasis model assessment of insulin resistance (HOMA-IR) (r = -.331, p < 0.05) when percent body fat was controlled. Multivariate linear regression analysis found serum vaspin level to be an independent predictor of insulin and HOMA-IR. Short-term intensive lifestyle modification significantly decreased vaspin levels by 39.28% (pre: .84 ± 1.0, post: .51 ± 1.0 ng/ml, p < 0.001) while adiponectin levels increased by 11.2% (pre: 6.50 ± 2.89, post: 7.28 ± 2.98 ng/ml, p < 0.01). In addition, short-term lifestyle modification significantly improved HOMA-IR (pre: 3.58 ± 1.93, post 1.30 ± 1.9, p < 0.001) and lipid profiles. Conclusions: Serum vaspin level is one of the predictors for insulin resistance and was significantly reduced following short-term lifestyle modification.

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