Reduced Theta-Band Power and Phase Synchrony during Explicit Verbal Memory Tasks in Female, Non-Clinical Individuals with Schizotypal Traits

Jeong Woo Choi, Kyoung Mi Jang, Ki Young Jung, Myung Sun Kim, Kyunghwan Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The study of non-clinical individuals with schizotypal traits has been considered to provide a promising endophenotypic approach to understanding schizophrenia, because schizophrenia is highly heterogeneous, and a number of confounding factors may affect neuropsychological performance. Here, we investigated whether deficits in explicit verbal memory in individuals with schizotypal traits are associated with abnormalities in the local and interregional synchrony of brain activity. Memory deficits have been recognized as a core problem in schizophrenia, and previous studies have consistently shown explicit verbal memory impairment in schizophrenic patients. However, the mechanism of this impairment has not been fully revealed. Seventeen individuals with schizotypal traits and 17 age-matched, normal controls participated. Multichannel event-related electroencephalograms (EEGs) were recorded while the subjects performed a continuous recognition task. Event-related spectral perturbations (ERSPs) and inter-regional theta-band phase locking values (TPLVs) were investigated to determine the differences in local and global neural synchrony between the two subject groups. Additionally, the connection patterns of the TPLVs were quantitatively analyzed using graph theory measures. An old/new effect was found in the induced thetaband ERSP in both groups. However, the difference between the old and new was larger in normal controls than in schizotypal trait group. The tendency of elevated old/new effect in normal controls was observed in anterior-posterior theta-band phase synchrony as well. Our results suggest that explicit memory deficits observed in schizophrenia patients can also be found in non-clinical individuals with psychometrically defined schizotypal traits.

Original languageEnglish
Article numbere0148272
JournalPLoS One
Volume11
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

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Schizophrenia
Data storage equipment
Memory Disorders
electroencephalography
Graph theory
Electroencephalography
Brain
brain
Power (Psychology)
schizophrenia

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

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Reduced Theta-Band Power and Phase Synchrony during Explicit Verbal Memory Tasks in Female, Non-Clinical Individuals with Schizotypal Traits. / Choi, Jeong Woo; Jang, Kyoung Mi; Jung, Ki Young; Kim, Myung Sun; Kim, Kyunghwan.

In: PLoS One, Vol. 11, No. 2, e0148272, 01.02.2016.

Research output: Contribution to journalArticle

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