Regional cerebral blood flow changes and performance deficit during a sustained attention task in schizophrenia: 15O-water positron emission tomography

Jeong Ho Seok, Hae Jeong Park, Jong Doo Lee, Hye Sun Kim, Ji Won Chun, Sang Joon Son, Maeng Keun Oh, Jeonghun Ku, Hyeongrae Lee, Jae Jin Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim: Attention deficit has been reported in both schizophrenia patients and patients with major depressive disorder (MDD). The aim of this study was to elucidate the deficits in sustained attention and associated neural network dysfunctions in schizophrenia patients and MDD patients, and to investigate the difference between the two patient groups. Methods Twelve schizophrenia patients, 12 patients with non-psychotic MDD, and 12 healthy control subjects participated in this study. A sustained attention to response task (SART) was used to measure attention capacity. Cerebral blood flow (CBF) during attention tasks was measured using H215O positron emission tomography. Statistical parametric mapping and analysis of covariance were performed to compare the behavioral performance and CBF changes during SART among three groups. Results: Behavioral performances were not significantly different among the three groups except for an increased commission error rate in the schizophrenia group. Regional CBF during SART was significantly reduced in the left inferior frontal gyrus, the left cuneus, and the right superior parietal lobule and increased in the right superior frontal gyrus and the right cuneus in the schizophrenia group compared to the healthy control group. In the MDD group, neither significant regional CBF difference nor behavioral deficit was found compared to the healthy control group. Conclusion: Behavioral performance deficit and perfusion changes in the prefrontal and parietal cortices during SART were observed only in the schizophrenia group. Prefrontal and parietal network dysfunction for sustained attention may be involved in the pathophysiology of schizophrenia.

Original languageEnglish
Pages (from-to)564-572
Number of pages9
JournalPsychiatry and Clinical Neurosciences
Volume66
Issue number7
DOIs
Publication statusPublished - 2012 Dec 1

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Cerebrovascular Circulation
Regional Blood Flow
Positron-Emission Tomography
Schizophrenia
Water
Major Depressive Disorder
Prefrontal Cortex
Occipital Lobe
Parietal Lobe
Control Groups
Healthy Volunteers
Perfusion

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Seok, Jeong Ho ; Park, Hae Jeong ; Lee, Jong Doo ; Kim, Hye Sun ; Chun, Ji Won ; Son, Sang Joon ; Oh, Maeng Keun ; Ku, Jeonghun ; Lee, Hyeongrae ; Kim, Jae Jin. / Regional cerebral blood flow changes and performance deficit during a sustained attention task in schizophrenia : 15O-water positron emission tomography. In: Psychiatry and Clinical Neurosciences. 2012 ; Vol. 66, No. 7. pp. 564-572.
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Regional cerebral blood flow changes and performance deficit during a sustained attention task in schizophrenia : 15O-water positron emission tomography. / Seok, Jeong Ho; Park, Hae Jeong; Lee, Jong Doo; Kim, Hye Sun; Chun, Ji Won; Son, Sang Joon; Oh, Maeng Keun; Ku, Jeonghun; Lee, Hyeongrae; Kim, Jae Jin.

In: Psychiatry and Clinical Neurosciences, Vol. 66, No. 7, 01.12.2012, p. 564-572.

Research output: Contribution to journalArticle

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T1 - Regional cerebral blood flow changes and performance deficit during a sustained attention task in schizophrenia

T2 - 15O-water positron emission tomography

AU - Seok, Jeong Ho

AU - Park, Hae Jeong

AU - Lee, Jong Doo

AU - Kim, Hye Sun

AU - Chun, Ji Won

AU - Son, Sang Joon

AU - Oh, Maeng Keun

AU - Ku, Jeonghun

AU - Lee, Hyeongrae

AU - Kim, Jae Jin

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N2 - Aim: Attention deficit has been reported in both schizophrenia patients and patients with major depressive disorder (MDD). The aim of this study was to elucidate the deficits in sustained attention and associated neural network dysfunctions in schizophrenia patients and MDD patients, and to investigate the difference between the two patient groups. Methods Twelve schizophrenia patients, 12 patients with non-psychotic MDD, and 12 healthy control subjects participated in this study. A sustained attention to response task (SART) was used to measure attention capacity. Cerebral blood flow (CBF) during attention tasks was measured using H215O positron emission tomography. Statistical parametric mapping and analysis of covariance were performed to compare the behavioral performance and CBF changes during SART among three groups. Results: Behavioral performances were not significantly different among the three groups except for an increased commission error rate in the schizophrenia group. Regional CBF during SART was significantly reduced in the left inferior frontal gyrus, the left cuneus, and the right superior parietal lobule and increased in the right superior frontal gyrus and the right cuneus in the schizophrenia group compared to the healthy control group. In the MDD group, neither significant regional CBF difference nor behavioral deficit was found compared to the healthy control group. Conclusion: Behavioral performance deficit and perfusion changes in the prefrontal and parietal cortices during SART were observed only in the schizophrenia group. Prefrontal and parietal network dysfunction for sustained attention may be involved in the pathophysiology of schizophrenia.

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