Broadening of nitrogenfused heteroaromatic chemical space such as indolizine and pyrrolo[1,2 a ]pyrazine was achieved via FeCl3catalyzed nucleophilic addition of these N fused aromatic compounds to a wide range of azolinium systems generated in situ, leading to novel N fused heteroaromatic scaffolds with dearomatized N heterocyclic substituents regioselectively. Nucleophilic addition of indolizines and pyrrolo[1,2 a ]pyrazines mainly occurred at the C1 position of the isoquinoliniums and at the C4 site of the quinoliniums.
Bibliographical noteFunding Information:
We thank the National Research Foundation of Korea (NRF-2018R1A6A1A03023718 and NRF-2020R1A2C2005961) for generous financial support.National ReeachFoundatonofKoeaNRF2018R1A6A1A03023718National ReseachFoundaionofKoea(NRF2020R1A2C2005961)
All Science Journal Classification (ASJC) codes
- Organic Chemistry