Regulation of abiotic stress signal transduction by E3 ubiquitin ligases in arabidopsis

Jae Hoon Lee, Woo Taek Kim

Research output: Contribution to journalReview articlepeer-review

112 Citations (Scopus)

Abstract

Ubiquitination is a unique protein degradation system utilized by eukaryotes to efficiently degrade detrimental cellular proteins and control the entire pool of regulatory components. In plants, adaptation in response to various abiotic stresses can be achieved through ubiquitination and the resulting degradation of components specific to these stress signalings. Arabidopsis has more than 1,400 E3 enzymes, indicating E3 ligase acts as a main determinant of substrate specificity. However, as only a minority of E3 ligases related to abiotic stress signaling have been studied in Arabidopsis, the further elucidation of the biological roles and related substrates of newly identified E3 ligases is essential in order to clarify the functional relationship between abiotic stress and E3 ligases. Here, we review the current knowledge and future prospects of the regulatory mechanism and role of several E3 ligases involved in abiotic stress signal transduction in Arabidopsis. As another potential approach to understand how ubiquitination is involved in such signaling, we also briefly introduce factors that regulate the activity of cullin in multisubunit E3 ligase complexes.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalMolecules and cells
Volume31
Issue number3
DOIs
Publication statusPublished - 2011 Mar

Bibliographical note

Funding Information:
The authors acknowledge Sunglan Chung (Yale University) for critical reading of the manuscript. This work was supported by grants from the National Research Foundation (Project No. 2009-007831 7 funded by the Ministry of Education, Science, and Technology, Republic of Korea), the Technology Development Program for Agriculture and Forestry (Project No. 30901 7-5 funded by the Ministry for Agriculture, Forestry and Fisheries, Republic of Korea), and the BioGreen 21 Program (funded by the Rural Development Administration, Republic of Korea) to W.T.K.

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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