Abstract
The maintenance of normal blood glucose levels at rest and during exercise is critical. The maintenance of blood glucose homeostasis depends on the coordination and integration of several physiological systems, including the sympathetic nervous system and the endocrine system. During prolonged exercise increased demand for glucose by contracting muscle causes to increase glucose uptake to working skeletal muscle. Increase in glucose uptake by working skeletal muscle during prolonged exercise is due to an increase in the translocation of insulin and contraction sensitive glucose transporter-4 (GLUT4) proteins to the plasma membrane. However, normal blood glucose level can be maintained by the augmentation of glucose production and release through the stimulation of liver glycogen breakdown, and the stimulation of the synthesis of glucose from other substances, and by the mobilization of other fuels that may serve as alternatives. Both feedback and feedforward mechanisms allow glycemia to be controlled during exercise. This review focuses on factors that control blood glucose homeostasis during prolonged exercise.
| Original language | English |
|---|---|
| Pages (from-to) | 272-279 |
| Number of pages | 8 |
| Journal | Molecules and cells |
| Volume | 23 |
| Issue number | 3 |
| Publication status | Published - 2007 Jun 30 |
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All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology
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Regulation of blood glucose homeostasis during prolonged exercise. / Suh, Sang Hoon; Paik, Il Young; Jacobs, Kevin A.
In: Molecules and cells, Vol. 23, No. 3, 30.06.2007, p. 272-279.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - Regulation of blood glucose homeostasis during prolonged exercise
AU - Suh, Sang Hoon
AU - Paik, Il Young
AU - Jacobs, Kevin A.
PY - 2007/6/30
Y1 - 2007/6/30
N2 - The maintenance of normal blood glucose levels at rest and during exercise is critical. The maintenance of blood glucose homeostasis depends on the coordination and integration of several physiological systems, including the sympathetic nervous system and the endocrine system. During prolonged exercise increased demand for glucose by contracting muscle causes to increase glucose uptake to working skeletal muscle. Increase in glucose uptake by working skeletal muscle during prolonged exercise is due to an increase in the translocation of insulin and contraction sensitive glucose transporter-4 (GLUT4) proteins to the plasma membrane. However, normal blood glucose level can be maintained by the augmentation of glucose production and release through the stimulation of liver glycogen breakdown, and the stimulation of the synthesis of glucose from other substances, and by the mobilization of other fuels that may serve as alternatives. Both feedback and feedforward mechanisms allow glycemia to be controlled during exercise. This review focuses on factors that control blood glucose homeostasis during prolonged exercise.
AB - The maintenance of normal blood glucose levels at rest and during exercise is critical. The maintenance of blood glucose homeostasis depends on the coordination and integration of several physiological systems, including the sympathetic nervous system and the endocrine system. During prolonged exercise increased demand for glucose by contracting muscle causes to increase glucose uptake to working skeletal muscle. Increase in glucose uptake by working skeletal muscle during prolonged exercise is due to an increase in the translocation of insulin and contraction sensitive glucose transporter-4 (GLUT4) proteins to the plasma membrane. However, normal blood glucose level can be maintained by the augmentation of glucose production and release through the stimulation of liver glycogen breakdown, and the stimulation of the synthesis of glucose from other substances, and by the mobilization of other fuels that may serve as alternatives. Both feedback and feedforward mechanisms allow glycemia to be controlled during exercise. This review focuses on factors that control blood glucose homeostasis during prolonged exercise.
UR - http://www.scopus.com/inward/record.url?scp=34547511306&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547511306&partnerID=8YFLogxK
M3 - Short survey
C2 - 17646701
AN - SCOPUS:34547511306
VL - 23
SP - 272
EP - 279
JO - Molecules and Cells
JF - Molecules and Cells
SN - 1016-8478
IS - 3
ER -