Regulation of DREAM expression by group I mGluR

Jinu Lee, Insook Kim, So Ra Oh, Suk Jin Ko, Mi Kyung Lim, Dong Goo Kim, Chul Hoon Kim

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Abstract

DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalKorean Journal of Physiology and Pharmacology
Volume15
Issue number2
DOIs
Publication statusPublished - 2011 Apr 1

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All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology

Cite this

Lee, J., Kim, I., Oh, S. R., Ko, S. J., Lim, M. K., Kim, D. G., & Kim, C. H. (2011). Regulation of DREAM expression by group I mGluR. Korean Journal of Physiology and Pharmacology, 15(2), 95-100. https://doi.org/10.4196/kjpp.2011.15.2.95