Regulation of DREAM expression by group I mGluR

Jinu Lee, Insook Kim, So Ra Oh, Suk Jin Ko, Mi Kyung Lim, Dong Goo Kim, Chul Hoon Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalKorean Journal of Physiology and Pharmacology
Volume15
Issue number2
DOIs
Publication statusPublished - 2011 Apr 1

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Proteins
Presenilins
Neurons
Dynorphins
Calcium-Binding Proteins
Potassium Channels
Cytoplasm
Up-Regulation
metabotropic glutamate receptor type 1
3,5-dihydroxyphenylglycine

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology

Cite this

Lee, J., Kim, I., Oh, S. R., Ko, S. J., Lim, M. K., Kim, D. G., & Kim, C. H. (2011). Regulation of DREAM expression by group I mGluR. Korean Journal of Physiology and Pharmacology, 15(2), 95-100. https://doi.org/10.4196/kjpp.2011.15.2.95
Lee, Jinu ; Kim, Insook ; Oh, So Ra ; Ko, Suk Jin ; Lim, Mi Kyung ; Kim, Dong Goo ; Kim, Chul Hoon. / Regulation of DREAM expression by group I mGluR. In: Korean Journal of Physiology and Pharmacology. 2011 ; Vol. 15, No. 2. pp. 95-100.
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Lee, J, Kim, I, Oh, SR, Ko, SJ, Lim, MK, Kim, DG & Kim, CH 2011, 'Regulation of DREAM expression by group I mGluR', Korean Journal of Physiology and Pharmacology, vol. 15, no. 2, pp. 95-100. https://doi.org/10.4196/kjpp.2011.15.2.95

Regulation of DREAM expression by group I mGluR. / Lee, Jinu; Kim, Insook; Oh, So Ra; Ko, Suk Jin; Lim, Mi Kyung; Kim, Dong Goo; Kim, Chul Hoon.

In: Korean Journal of Physiology and Pharmacology, Vol. 15, No. 2, 01.04.2011, p. 95-100.

Research output: Contribution to journalArticle

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