Regulation of Escherichia coli pyrC by the purine regulon repressor protein

Kang-Yell Choi, H. Zalkin

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The purine regulon repressor, PurR, was identified as a component of the Escherichia coli regulatory system for pyrC, the gene that encodes dihydroorotase, an enzyme in the novo pyrimidine nucleotide synthesis. PurR binds to a pyrC control site that resembles a pur regulon operator and represses expression by twofold. Mutations that increase binding of PurR to the control site in vitro concomitantly increase in vivo regulation. There are completely independent mechanisms for regulation of pyrC by purine and pyrimidine nucleotides. Cross pathway regulation of pyrC by PurR may provide one mechanism to coordinate synthesis of purine and pyrimidine nucleotides.

Original languageEnglish
Pages (from-to)3201-3207
Number of pages7
JournalJournal of Bacteriology
Volume172
Issue number6
DOIs
Publication statusPublished - 1990 Jan 1

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Pyrimidine Nucleotides
Repressor Proteins
Regulon
Purine Nucleotides
Escherichia coli
Dihydroorotase
Mutation
Enzymes
Genes
purine

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

Cite this

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Regulation of Escherichia coli pyrC by the purine regulon repressor protein. / Choi, Kang-Yell; Zalkin, H.

In: Journal of Bacteriology, Vol. 172, No. 6, 01.01.1990, p. 3201-3207.

Research output: Contribution to journalArticle

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