Regulation of root patterns in mammalian teeth

Hyejin Seo, Jinsun Kim, Jae Joon Hwang, Ho Gul Jeong, Sang Sun Han, Wonse Park, Kanghyun Ryu, Hong Seomun, Jae Young Kim, Eui Sic Cho, Joo Cheol Park, Kyung Seok Hu, Hee Jin Kim, Dong Hyun Kim, Sung Won Cho

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Abstract

Mammalian teeth have diverse pattern of the crown and root. The patterning mechanism of the root position and number is relatively unknown compared to that of the crown. The root number does not always match to the cusp number, which has prevented the complete understanding of root patterning. In the present study, to elucidate the mechanism of root pattern formation, we examined (1) the pattern of cervical tongues, which are tongue-like epithelial processes extending from cervical loops, (2) factors influencing the cervical tongue pattern and (3) the relationship among patterns of cusp, cervical tongue and root in multi-rooted teeth. We found a simple mechanism of cervical tongue formation in which the lateral growth of dental mesenchyme in the cuspal region pushes the cervical loop outward, and the cervical tongue appears in the intercuspal region subsequently. In contrast, when lateral growth was physically inhibited, cervical tongue formation was suppressed. Furthermore, by building simple formulas to predict the maximum number of cervical tongues and roots based on the cusp pattern, we demonstrated a positive relationship among cusp, cervical tongue and root numbers. These results suggest that the cusp pattern and the lateral growth of cusps are important in the regulation of the root pattern.

Original languageEnglish
Article number2714
JournalScientific reports
Volume7
Issue number1
DOIs
Publication statusPublished - 2017 Dec 1

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Seo, H., Kim, J., Hwang, J. J., Jeong, H. G., Han, S. S., Park, W., ... Cho, S. W. (2017). Regulation of root patterns in mammalian teeth. Scientific reports, 7(1), [2714]. https://doi.org/10.1038/s41598-017-12745-1
Seo, Hyejin ; Kim, Jinsun ; Hwang, Jae Joon ; Jeong, Ho Gul ; Han, Sang Sun ; Park, Wonse ; Ryu, Kanghyun ; Seomun, Hong ; Kim, Jae Young ; Cho, Eui Sic ; Park, Joo Cheol ; Hu, Kyung Seok ; Kim, Hee Jin ; Kim, Dong Hyun ; Cho, Sung Won. / Regulation of root patterns in mammalian teeth. In: Scientific reports. 2017 ; Vol. 7, No. 1.
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abstract = "Mammalian teeth have diverse pattern of the crown and root. The patterning mechanism of the root position and number is relatively unknown compared to that of the crown. The root number does not always match to the cusp number, which has prevented the complete understanding of root patterning. In the present study, to elucidate the mechanism of root pattern formation, we examined (1) the pattern of cervical tongues, which are tongue-like epithelial processes extending from cervical loops, (2) factors influencing the cervical tongue pattern and (3) the relationship among patterns of cusp, cervical tongue and root in multi-rooted teeth. We found a simple mechanism of cervical tongue formation in which the lateral growth of dental mesenchyme in the cuspal region pushes the cervical loop outward, and the cervical tongue appears in the intercuspal region subsequently. In contrast, when lateral growth was physically inhibited, cervical tongue formation was suppressed. Furthermore, by building simple formulas to predict the maximum number of cervical tongues and roots based on the cusp pattern, we demonstrated a positive relationship among cusp, cervical tongue and root numbers. These results suggest that the cusp pattern and the lateral growth of cusps are important in the regulation of the root pattern.",
author = "Hyejin Seo and Jinsun Kim and Hwang, {Jae Joon} and Jeong, {Ho Gul} and Han, {Sang Sun} and Wonse Park and Kanghyun Ryu and Hong Seomun and Kim, {Jae Young} and Cho, {Eui Sic} and Park, {Joo Cheol} and Hu, {Kyung Seok} and Kim, {Hee Jin} and Kim, {Dong Hyun} and Cho, {Sung Won}",
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Seo, H, Kim, J, Hwang, JJ, Jeong, HG, Han, SS, Park, W, Ryu, K, Seomun, H, Kim, JY, Cho, ES, Park, JC, Hu, KS, Kim, HJ, Kim, DH & Cho, SW 2017, 'Regulation of root patterns in mammalian teeth', Scientific reports, vol. 7, no. 1, 2714. https://doi.org/10.1038/s41598-017-12745-1

Regulation of root patterns in mammalian teeth. / Seo, Hyejin; Kim, Jinsun; Hwang, Jae Joon; Jeong, Ho Gul; Han, Sang Sun; Park, Wonse; Ryu, Kanghyun; Seomun, Hong; Kim, Jae Young; Cho, Eui Sic; Park, Joo Cheol; Hu, Kyung Seok; Kim, Hee Jin; Kim, Dong Hyun; Cho, Sung Won.

In: Scientific reports, Vol. 7, No. 1, 2714, 01.12.2017.

Research output: Contribution to journalArticle

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AU - Seo, Hyejin

AU - Kim, Jinsun

AU - Hwang, Jae Joon

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AU - Park, Wonse

AU - Ryu, Kanghyun

AU - Seomun, Hong

AU - Kim, Jae Young

AU - Cho, Eui Sic

AU - Park, Joo Cheol

AU - Hu, Kyung Seok

AU - Kim, Hee Jin

AU - Kim, Dong Hyun

AU - Cho, Sung Won

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N2 - Mammalian teeth have diverse pattern of the crown and root. The patterning mechanism of the root position and number is relatively unknown compared to that of the crown. The root number does not always match to the cusp number, which has prevented the complete understanding of root patterning. In the present study, to elucidate the mechanism of root pattern formation, we examined (1) the pattern of cervical tongues, which are tongue-like epithelial processes extending from cervical loops, (2) factors influencing the cervical tongue pattern and (3) the relationship among patterns of cusp, cervical tongue and root in multi-rooted teeth. We found a simple mechanism of cervical tongue formation in which the lateral growth of dental mesenchyme in the cuspal region pushes the cervical loop outward, and the cervical tongue appears in the intercuspal region subsequently. In contrast, when lateral growth was physically inhibited, cervical tongue formation was suppressed. Furthermore, by building simple formulas to predict the maximum number of cervical tongues and roots based on the cusp pattern, we demonstrated a positive relationship among cusp, cervical tongue and root numbers. These results suggest that the cusp pattern and the lateral growth of cusps are important in the regulation of the root pattern.

AB - Mammalian teeth have diverse pattern of the crown and root. The patterning mechanism of the root position and number is relatively unknown compared to that of the crown. The root number does not always match to the cusp number, which has prevented the complete understanding of root patterning. In the present study, to elucidate the mechanism of root pattern formation, we examined (1) the pattern of cervical tongues, which are tongue-like epithelial processes extending from cervical loops, (2) factors influencing the cervical tongue pattern and (3) the relationship among patterns of cusp, cervical tongue and root in multi-rooted teeth. We found a simple mechanism of cervical tongue formation in which the lateral growth of dental mesenchyme in the cuspal region pushes the cervical loop outward, and the cervical tongue appears in the intercuspal region subsequently. In contrast, when lateral growth was physically inhibited, cervical tongue formation was suppressed. Furthermore, by building simple formulas to predict the maximum number of cervical tongues and roots based on the cusp pattern, we demonstrated a positive relationship among cusp, cervical tongue and root numbers. These results suggest that the cusp pattern and the lateral growth of cusps are important in the regulation of the root pattern.

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Seo H, Kim J, Hwang JJ, Jeong HG, Han SS, Park W et al. Regulation of root patterns in mammalian teeth. Scientific reports. 2017 Dec 1;7(1). 2714. https://doi.org/10.1038/s41598-017-12745-1