Regulation of the Hippo pathway and implications for anticancer drug development

Hyun Woo Park, Kun Liang Guan

Research output: Contribution to journalReview article

74 Citations (Scopus)

Abstract

Research in the past decade has revealed key components of the Hippo tumor suppressor pathway and its critical role in organ size regulation and tumorigenesis. Recent progress has identified a wide range of upstream factors that control the Hippo pathway, which include cell-cell contact, various diffusible signals, and cognate receptors. Dysregulation of the Hippo pathway, caused by gene mutation or aberrant expression, promotes cell proliferation and tumorigenesis. Here, we discuss the current state of Hippo pathway research, primarily focusing on upstream regulators and protein-protein interactions as potential therapeutic targets. Consideration of pharmacological intervention of the Hippo pathway may provide novel avenues for future therapeutic treatment of human diseases, particularly in cancer.

Original languageEnglish
Pages (from-to)581-589
Number of pages9
JournalTrends in Pharmacological Sciences
Volume34
Issue number10
DOIs
Publication statusPublished - 2013 Oct

Bibliographical note

Funding Information:
We thank all the members of the laboratory for helpful discussions. Research in the laboratory of K-L.G. is supported by grants from the National Institutes of Health.

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

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