Regulatory network of ARF in cancer development

Aram Ko, Su Yeon Han, Jaewhan Song

Research output: Contribution to journalShort surveypeer-review

11 Citations (Scopus)

Abstract

ARF is a tumor suppressor protein that has a pivotal role in the prevention of cancer development through regulating cell proliferation, senescence, and apoptosis. As a factor that induces senescence, the role of ARF as a tumor suppressor is closely linked to the p53-MDM2 axis, which is a key process that restrains tumor formation. Thus, many cancer cells either lack a functional ARF or p53, which enables them to evade cell oncogenic stress-mediated cycle arrest, senescence, or apoptosis. In particular, the ARF gene is a frequent target of genetic and epigenetic alterations including promoter hypermethylation or gene deletion. However, as many cancer cells still express ARF, pathways that negatively modulate transcriptional or post-translational regulation of ARF could be potentially important means for cancer cells to induce cellular proliferation. These recent findings of regulators affecting ARF protein stability along with its low levels in numerous human cancers indicate the significance of an ARF posttranslational mechanism in cancers. Novel findings of regulators stimulating or suppressing ARF function would provide new therapeutic targets to manage cancer-and senescence-related diseases. In this review, we present the current knowledge on the regulation and alterations of ARF expression in human cancers, and indicate the importance of regulators of ARF as a prognostic marker and in potential therapeutic strategies.

Original languageEnglish
Pages (from-to)381-389
Number of pages9
JournalMolecules and cells
Volume41
Issue number5
DOIs
Publication statusPublished - 2018

Bibliographical note

Funding Information:
This work was supported by grants from the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science, Creative Research Initiative Program of NRF (2015R1A3A2066581) funded by the Ministry of Science, ICT.

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Regulatory network of ARF in cancer development'. Together they form a unique fingerprint.

Cite this