Regulatory peptides are susceptible to oxidation by metallic impurities within carbon nanotubes

Adriano Ambrosi, Martin Pumera

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

In this article, we show that the redox properties of the regulatory peptide L-glutathione are affected by the presence of nickel oxide impurities within single-walled carbon nanotubes (SWCNTs). Glutathione is a powerful antioxidant that protects cells from oxidative stress by removing free radicals and peroxides. We show that the L-cysteine moiety in L-glutathione is responsible for the susceptibility to oxidation by metallic impurities present in the carbon nanotubes. These results have great significance for assessing the toxicity of carbon-nanotube materials. The SWCNTs were characterized by Raman spectroscopy, high-resolution X-ray photoelectron spectroscopy, transmission electron microscopy, and energy dispersive X-ray spectroscopy.

Original languageEnglish
Pages (from-to)1786-1792
Number of pages7
JournalChemistry - A European Journal
Volume16
Issue number6
DOIs
Publication statusPublished - 2010 Feb 8

Fingerprint

Carbon Nanotubes
Peptides
Glutathione
Carbon nanotubes
Single-walled carbon nanotubes (SWCN)
Impurities
Oxidation
Nickel oxide
Oxidative stress
Peroxides
Antioxidants
Free radicals
Free Radicals
Cysteine
Toxicity
Raman spectroscopy
X ray photoelectron spectroscopy
Transmission electron microscopy

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

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Regulatory peptides are susceptible to oxidation by metallic impurities within carbon nanotubes. / Ambrosi, Adriano; Pumera, Martin.

In: Chemistry - A European Journal, Vol. 16, No. 6, 08.02.2010, p. 1786-1792.

Research output: Contribution to journalArticle

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