Regulatory peptides are susceptible to oxidation by metallic impurities within carbon nanotubes

Adriano Ambrosi, Martin Pumera

Research output: Contribution to journalArticle

71 Citations (Scopus)


In this article, we show that the redox properties of the regulatory peptide L-glutathione are affected by the presence of nickel oxide impurities within single-walled carbon nanotubes (SWCNTs). Glutathione is a powerful antioxidant that protects cells from oxidative stress by removing free radicals and peroxides. We show that the L-cysteine moiety in L-glutathione is responsible for the susceptibility to oxidation by metallic impurities present in the carbon nanotubes. These results have great significance for assessing the toxicity of carbon-nanotube materials. The SWCNTs were characterized by Raman spectroscopy, high-resolution X-ray photoelectron spectroscopy, transmission electron microscopy, and energy dispersive X-ray spectroscopy.

Original languageEnglish
Pages (from-to)1786-1792
Number of pages7
JournalChemistry - A European Journal
Issue number6
Publication statusPublished - 2010 Feb 8


All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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