Relation between residual plaque burden after stenting and six-month angiographic restenosis

Myeongki Hong, Seong Wook Park, Cheol Whan Lee, Young Hak Kim, Jong Min Song, Duk Hyun Kang, Jae Kwan Song, Jae Joong Kim, Seung Jung Park

Research output: Contribution to journalArticle

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Abstract

The degree of residual plaque burden outside of a stent might be correlated with the degree of intimal hyperplasia. However, the relation between residual plaque burden and angiographic restenosis are still unknown in a large number of patients. Therefore, we evaluated the effect of residual plaque burden after stenting on 6-month angiographic restenosis. Intravascular ultrasound (IVUS)-guided coronary stenting was successfully performed in 723 patients with 785 native coronary lesions. Six-month follow-up angiograms and evaluation of residual plaque burden by IVUS were available in 566 patients (78.3%) with 622 lesions (79.2%). Results were evaluated using conventional methods. The overall angiographic restenosis rate was 23.0% (143 of 622 lesions). There was no significant difference in residual plaque burden between the lesions with and without restenosis (52% vs 51%, respectively, p = 0.148). The angiographic restenosis rate was 20.8% (11 of 53 lesions), 21.6% (51 of 236 lesions), 22.0% (55 of 250 lesions), and 31.3% (26 of 83 lesions) in the lesions with residual plaque burden <40%, between 40% and 50%, between 50% and 60%, and >60%, respectively (p = 0.284). Using multivariate logistic regression analysis, the only independent predictor of angiographic restenosis was the IVUS stent area (odds ratio 0.807, 95% confidence intervals 0.69 to 0.95, p = 0.011). Furthermore, even in the lesions with residual plaque burden >60%, the restenosis rate was 37.3% (23 of 61 lesions) versus 13.6% (3 of 22 lesions ) in IVUS stent areas of <7 and ≥7 mm 2 , respectively (p = 0.031). In conclusion, residual plaque burden outside the stent might not predict angiographic restenosis. IVUS stent area was the only independent predictor of angiographic restenosis.

Original languageEnglish
Pages (from-to)368-371
Number of pages4
JournalAmerican Journal of Cardiology
Volume89
Issue number4
DOIs
Publication statusPublished - 2002 Feb 15

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Stents
Tunica Intima
Hyperplasia
Angiography
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hong, Myeongki ; Park, Seong Wook ; Lee, Cheol Whan ; Kim, Young Hak ; Song, Jong Min ; Kang, Duk Hyun ; Song, Jae Kwan ; Kim, Jae Joong ; Park, Seung Jung. / Relation between residual plaque burden after stenting and six-month angiographic restenosis. In: American Journal of Cardiology. 2002 ; Vol. 89, No. 4. pp. 368-371.
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title = "Relation between residual plaque burden after stenting and six-month angiographic restenosis",
abstract = "The degree of residual plaque burden outside of a stent might be correlated with the degree of intimal hyperplasia. However, the relation between residual plaque burden and angiographic restenosis are still unknown in a large number of patients. Therefore, we evaluated the effect of residual plaque burden after stenting on 6-month angiographic restenosis. Intravascular ultrasound (IVUS)-guided coronary stenting was successfully performed in 723 patients with 785 native coronary lesions. Six-month follow-up angiograms and evaluation of residual plaque burden by IVUS were available in 566 patients (78.3{\%}) with 622 lesions (79.2{\%}). Results were evaluated using conventional methods. The overall angiographic restenosis rate was 23.0{\%} (143 of 622 lesions). There was no significant difference in residual plaque burden between the lesions with and without restenosis (52{\%} vs 51{\%}, respectively, p = 0.148). The angiographic restenosis rate was 20.8{\%} (11 of 53 lesions), 21.6{\%} (51 of 236 lesions), 22.0{\%} (55 of 250 lesions), and 31.3{\%} (26 of 83 lesions) in the lesions with residual plaque burden <40{\%}, between 40{\%} and 50{\%}, between 50{\%} and 60{\%}, and >60{\%}, respectively (p = 0.284). Using multivariate logistic regression analysis, the only independent predictor of angiographic restenosis was the IVUS stent area (odds ratio 0.807, 95{\%} confidence intervals 0.69 to 0.95, p = 0.011). Furthermore, even in the lesions with residual plaque burden >60{\%}, the restenosis rate was 37.3{\%} (23 of 61 lesions) versus 13.6{\%} (3 of 22 lesions ) in IVUS stent areas of <7 and ≥7 mm 2 , respectively (p = 0.031). In conclusion, residual plaque burden outside the stent might not predict angiographic restenosis. IVUS stent area was the only independent predictor of angiographic restenosis.",
author = "Myeongki Hong and Park, {Seong Wook} and Lee, {Cheol Whan} and Kim, {Young Hak} and Song, {Jong Min} and Kang, {Duk Hyun} and Song, {Jae Kwan} and Kim, {Jae Joong} and Park, {Seung Jung}",
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Hong, M, Park, SW, Lee, CW, Kim, YH, Song, JM, Kang, DH, Song, JK, Kim, JJ & Park, SJ 2002, 'Relation between residual plaque burden after stenting and six-month angiographic restenosis', American Journal of Cardiology, vol. 89, no. 4, pp. 368-371. https://doi.org/10.1016/S0002-9149(01)02253-6

Relation between residual plaque burden after stenting and six-month angiographic restenosis. / Hong, Myeongki; Park, Seong Wook; Lee, Cheol Whan; Kim, Young Hak; Song, Jong Min; Kang, Duk Hyun; Song, Jae Kwan; Kim, Jae Joong; Park, Seung Jung.

In: American Journal of Cardiology, Vol. 89, No. 4, 15.02.2002, p. 368-371.

Research output: Contribution to journalArticle

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T1 - Relation between residual plaque burden after stenting and six-month angiographic restenosis

AU - Hong, Myeongki

AU - Park, Seong Wook

AU - Lee, Cheol Whan

AU - Kim, Young Hak

AU - Song, Jong Min

AU - Kang, Duk Hyun

AU - Song, Jae Kwan

AU - Kim, Jae Joong

AU - Park, Seung Jung

PY - 2002/2/15

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N2 - The degree of residual plaque burden outside of a stent might be correlated with the degree of intimal hyperplasia. However, the relation between residual plaque burden and angiographic restenosis are still unknown in a large number of patients. Therefore, we evaluated the effect of residual plaque burden after stenting on 6-month angiographic restenosis. Intravascular ultrasound (IVUS)-guided coronary stenting was successfully performed in 723 patients with 785 native coronary lesions. Six-month follow-up angiograms and evaluation of residual plaque burden by IVUS were available in 566 patients (78.3%) with 622 lesions (79.2%). Results were evaluated using conventional methods. The overall angiographic restenosis rate was 23.0% (143 of 622 lesions). There was no significant difference in residual plaque burden between the lesions with and without restenosis (52% vs 51%, respectively, p = 0.148). The angiographic restenosis rate was 20.8% (11 of 53 lesions), 21.6% (51 of 236 lesions), 22.0% (55 of 250 lesions), and 31.3% (26 of 83 lesions) in the lesions with residual plaque burden <40%, between 40% and 50%, between 50% and 60%, and >60%, respectively (p = 0.284). Using multivariate logistic regression analysis, the only independent predictor of angiographic restenosis was the IVUS stent area (odds ratio 0.807, 95% confidence intervals 0.69 to 0.95, p = 0.011). Furthermore, even in the lesions with residual plaque burden >60%, the restenosis rate was 37.3% (23 of 61 lesions) versus 13.6% (3 of 22 lesions ) in IVUS stent areas of <7 and ≥7 mm 2 , respectively (p = 0.031). In conclusion, residual plaque burden outside the stent might not predict angiographic restenosis. IVUS stent area was the only independent predictor of angiographic restenosis.

AB - The degree of residual plaque burden outside of a stent might be correlated with the degree of intimal hyperplasia. However, the relation between residual plaque burden and angiographic restenosis are still unknown in a large number of patients. Therefore, we evaluated the effect of residual plaque burden after stenting on 6-month angiographic restenosis. Intravascular ultrasound (IVUS)-guided coronary stenting was successfully performed in 723 patients with 785 native coronary lesions. Six-month follow-up angiograms and evaluation of residual plaque burden by IVUS were available in 566 patients (78.3%) with 622 lesions (79.2%). Results were evaluated using conventional methods. The overall angiographic restenosis rate was 23.0% (143 of 622 lesions). There was no significant difference in residual plaque burden between the lesions with and without restenosis (52% vs 51%, respectively, p = 0.148). The angiographic restenosis rate was 20.8% (11 of 53 lesions), 21.6% (51 of 236 lesions), 22.0% (55 of 250 lesions), and 31.3% (26 of 83 lesions) in the lesions with residual plaque burden <40%, between 40% and 50%, between 50% and 60%, and >60%, respectively (p = 0.284). Using multivariate logistic regression analysis, the only independent predictor of angiographic restenosis was the IVUS stent area (odds ratio 0.807, 95% confidence intervals 0.69 to 0.95, p = 0.011). Furthermore, even in the lesions with residual plaque burden >60%, the restenosis rate was 37.3% (23 of 61 lesions) versus 13.6% (3 of 22 lesions ) in IVUS stent areas of <7 and ≥7 mm 2 , respectively (p = 0.031). In conclusion, residual plaque burden outside the stent might not predict angiographic restenosis. IVUS stent area was the only independent predictor of angiographic restenosis.

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