Relation of homocysteinemia to contrast-induced nephropathy in patients undergoing percutaneous coronary intervention

Seung Jun Kim, Donghoon Choi, Young Guk Ko, Jung Sun Kim, Seung Hyeok Han, Byung Keuk Kim, Shin Wook Kang, Myeong Ki Hong, Yangsoo Jang, Kyu Hun Choi, Tae Hyun Yoo

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Abstract

Hyperhomocysteinemia induces oxidative stress and endothelial dysfunction, which share the proposed pathophysiologic mechanisms of contrast-induced nephropathy (CIN). However, no study has investigated the relation between hyperhomocysteinemia and CIN. The aim of the present study was to evaluate the effects of hyperhomocysteinemia on CIN in patients undergoing percutaneous coronary intervention. This was an observational cohort study that included 572 patients who underwent percutaneous coronary intervention. CIN was defined as an absolute <0.5 mg/dl or a relative <25% increase in the serum creatinine level at 48 hours after the procedure. The incidence of CIN was significantly greater in patients in the third homocysteine tertile (from lowest to highest, 4.7%, 7.3%, and 24.2%, p <0.001). Furthermore, the homocysteine levels were significantly greater in patients with CIN than in those without CIN (16.9 ± 4.9 vs 13.5 ± 4.2 μmol/L, p <0.001). In multiple logistic regression models, hyperhomocysteinemia was an independent risk factor for CIN (per the SD change in the plasma homocysteine level [4.44 μmol/L], odds ratio 1.70, 95% confidence interval 1.07 to 2.71, p = 0.025) after adjusting for major risk factors such as age, diabetes, and baseline cardiac and renal function. In subgroup analyses according to diabetes, acute coronary syndrome, or baseline estimated glomerular filtration rate, significant, graded associations were found between the homocysteine level and the incidence of CIN. In conclusion, hyperhomocysteinemia is independently associated with a greater risk of CIN in patients undergoing percutaneous coronary intervention.

Original languageEnglish
Pages (from-to)1086-1091
Number of pages6
JournalAmerican Journal of Cardiology
Volume108
Issue number8
DOIs
Publication statusPublished - 2011 Oct 15

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Hyperhomocysteinemia
Percutaneous Coronary Intervention
Homocysteine
Logistic Models
Incidence
Acute Coronary Syndrome
Glomerular Filtration Rate
Observational Studies
Creatinine
Oxidative Stress
Cohort Studies
Odds Ratio
Homocysteinemia
Confidence Intervals
Kidney
Serum

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{d58ca8a487404fc3a2fa56619f58f557,
title = "Relation of homocysteinemia to contrast-induced nephropathy in patients undergoing percutaneous coronary intervention",
abstract = "Hyperhomocysteinemia induces oxidative stress and endothelial dysfunction, which share the proposed pathophysiologic mechanisms of contrast-induced nephropathy (CIN). However, no study has investigated the relation between hyperhomocysteinemia and CIN. The aim of the present study was to evaluate the effects of hyperhomocysteinemia on CIN in patients undergoing percutaneous coronary intervention. This was an observational cohort study that included 572 patients who underwent percutaneous coronary intervention. CIN was defined as an absolute <0.5 mg/dl or a relative <25{\%} increase in the serum creatinine level at 48 hours after the procedure. The incidence of CIN was significantly greater in patients in the third homocysteine tertile (from lowest to highest, 4.7{\%}, 7.3{\%}, and 24.2{\%}, p <0.001). Furthermore, the homocysteine levels were significantly greater in patients with CIN than in those without CIN (16.9 ± 4.9 vs 13.5 ± 4.2 μmol/L, p <0.001). In multiple logistic regression models, hyperhomocysteinemia was an independent risk factor for CIN (per the SD change in the plasma homocysteine level [4.44 μmol/L], odds ratio 1.70, 95{\%} confidence interval 1.07 to 2.71, p = 0.025) after adjusting for major risk factors such as age, diabetes, and baseline cardiac and renal function. In subgroup analyses according to diabetes, acute coronary syndrome, or baseline estimated glomerular filtration rate, significant, graded associations were found between the homocysteine level and the incidence of CIN. In conclusion, hyperhomocysteinemia is independently associated with a greater risk of CIN in patients undergoing percutaneous coronary intervention.",
author = "Kim, {Seung Jun} and Donghoon Choi and Ko, {Young Guk} and Kim, {Jung Sun} and Han, {Seung Hyeok} and Kim, {Byung Keuk} and Kang, {Shin Wook} and Hong, {Myeong Ki} and Yangsoo Jang and Choi, {Kyu Hun} and Yoo, {Tae Hyun}",
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Relation of homocysteinemia to contrast-induced nephropathy in patients undergoing percutaneous coronary intervention. / Kim, Seung Jun; Choi, Donghoon; Ko, Young Guk; Kim, Jung Sun; Han, Seung Hyeok; Kim, Byung Keuk; Kang, Shin Wook; Hong, Myeong Ki; Jang, Yangsoo; Choi, Kyu Hun; Yoo, Tae Hyun.

In: American Journal of Cardiology, Vol. 108, No. 8, 15.10.2011, p. 1086-1091.

Research output: Contribution to journalArticle

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T1 - Relation of homocysteinemia to contrast-induced nephropathy in patients undergoing percutaneous coronary intervention

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AU - Kim, Jung Sun

AU - Han, Seung Hyeok

AU - Kim, Byung Keuk

AU - Kang, Shin Wook

AU - Hong, Myeong Ki

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AU - Choi, Kyu Hun

AU - Yoo, Tae Hyun

PY - 2011/10/15

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N2 - Hyperhomocysteinemia induces oxidative stress and endothelial dysfunction, which share the proposed pathophysiologic mechanisms of contrast-induced nephropathy (CIN). However, no study has investigated the relation between hyperhomocysteinemia and CIN. The aim of the present study was to evaluate the effects of hyperhomocysteinemia on CIN in patients undergoing percutaneous coronary intervention. This was an observational cohort study that included 572 patients who underwent percutaneous coronary intervention. CIN was defined as an absolute <0.5 mg/dl or a relative <25% increase in the serum creatinine level at 48 hours after the procedure. The incidence of CIN was significantly greater in patients in the third homocysteine tertile (from lowest to highest, 4.7%, 7.3%, and 24.2%, p <0.001). Furthermore, the homocysteine levels were significantly greater in patients with CIN than in those without CIN (16.9 ± 4.9 vs 13.5 ± 4.2 μmol/L, p <0.001). In multiple logistic regression models, hyperhomocysteinemia was an independent risk factor for CIN (per the SD change in the plasma homocysteine level [4.44 μmol/L], odds ratio 1.70, 95% confidence interval 1.07 to 2.71, p = 0.025) after adjusting for major risk factors such as age, diabetes, and baseline cardiac and renal function. In subgroup analyses according to diabetes, acute coronary syndrome, or baseline estimated glomerular filtration rate, significant, graded associations were found between the homocysteine level and the incidence of CIN. In conclusion, hyperhomocysteinemia is independently associated with a greater risk of CIN in patients undergoing percutaneous coronary intervention.

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