Relation of vasodilator response of the brachial artery to inflammatory markers in patients with coronary artery disease

Seok Min Kang, Namsik Chung, Ji Young Kim, Bon Kwon Koo, Donghoon Choi, Yangsoo Jang, Seung Yun Cho

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Endothelial dysfunction of the coronary artery is closely related to elevated levels of systemic inflammatory markers and cardiovascular events in patients with coronary artery disease (CAD). We hypothesized that patients with CAD may have a higher risk of endothelial dysfunction of the peripheral artery than patients without evidence of CAD, and that endothelial dysfunction of the peripheral artery also may be related to elevated levels of inflammatory markers. Using high resolution ultrasound, we assessed the brachial vasodilator response to reactive hyperemia (endothelium-dependent) and sublingual nitroglycerin (endothelium-independent). As inflammatory markers, serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) levels, and lipid profiles were measured in patients with CAD (n = 30, 16 male and 14 female) and normal subjects without evidence of CAD (n = 45, 23 male and 22 female). Patients with CAD (Group II) showed a significantly reduced endothelium-dependent vasodilation as compared with normal subjects (Group I) (4.4 ± 3.6 vs 7.4 ± 6.1%, P < 0.05). However, endothelium-independent vasodilation was not significantly different between the two groups (7.7 ± 7.1 vs 9.7 ± 8.0%, P > 0.05). In Group II, CRP level was inversely related to endothelium-dependent vasodilation (r = -0.398, P = 0.029). In contrast, ESR level was not significantly associated to endothelium-dependent vasodilation (r = -0.113, P = 0.552). On multivariate analysis, CRP and low density lipoprotein cholesterol levels were significant independent predictors of a blunted endothelium-dependent vasodilation in Group II. Our study showed that elevated CRP level was associated with blunted endothelium-dependent vasodilation of the brachial artery in patients with CAD. Thus, identification of elevated CRP levels combined with demonstration of endothelial dysfunction of the brachial artery may have a possible clinical application for the detection of high risk CAD patients.

Original languageEnglish
Pages (from-to)661-667
Number of pages7
JournalEchocardiography
Volume19
Issue number8
DOIs
Publication statusPublished - 2002 Nov

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Relation of vasodilator response of the brachial artery to inflammatory markers in patients with coronary artery disease'. Together they form a unique fingerprint.

  • Cite this