Abstract
Aims: To investigate associations between γ-glutamyltransferase (GGT) and components of metabolic syndrome (MS), insulin resistance and inflammatory markers in the Korean population. Methods: The 3508 subjects enrolled in this survey participated in the Korean Rural Genomic Cohort (KRGC) study. Written consent was obtained from the local ethical committee. Of these participants, 1437 were men (mean age 56.9 ± 7.9 years) and 2071 were women (mean age 55.8 ± 8.1 years). We measured GGT levels and various biochemical markers. To examine insulin resistance status, we used the homeostasis assessment method for insulin resistance (HOMA-IR). For inflammatory marker, we used C-reactive protein (CRP) levels. Results: Serum GGT levels were significantly higher in the MS group compared to the healthy patient group [23 (5-1403) vs. 19 (5-1920) IU/l; P = 0.01]. The prevalence of MS and adjusted relative risk were both significantly increased from the lowest to highest GGT quartiles; these results persisted after adjustments for multiple confounders. Positive correlations were established between GGT and HOMA-IR or CRP. Conclusion: These results suggest that GGT levels may be a surrogate marker of insulin resistance, inflammation and MS.
| Original language | English |
|---|---|
| Pages (from-to) | 469-475 |
| Number of pages | 7 |
| Journal | Diabetic Medicine |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2008 Apr 1 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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Relationship between γ-glutamyltransferase and metabolic syndrome in a Korean population. / Lee, M. Y.; Koh, S. B.; Koh, J. H.; Nam, S. M.; Shin, J. Y.; Shin, Y. G.; Kong, I. D.; Ryu, S. Y.; Lee, T. Y.; Park, J. K.; Chung, C. H.
In: Diabetic Medicine, Vol. 25, No. 4, 01.04.2008, p. 469-475.Research output: Contribution to journal › Article
TY - JOUR
T1 - Relationship between γ-glutamyltransferase and metabolic syndrome in a Korean population
AU - Lee, M. Y.
AU - Koh, S. B.
AU - Koh, J. H.
AU - Nam, S. M.
AU - Shin, J. Y.
AU - Shin, Y. G.
AU - Kong, I. D.
AU - Ryu, S. Y.
AU - Lee, T. Y.
AU - Park, J. K.
AU - Chung, C. H.
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Aims: To investigate associations between γ-glutamyltransferase (GGT) and components of metabolic syndrome (MS), insulin resistance and inflammatory markers in the Korean population. Methods: The 3508 subjects enrolled in this survey participated in the Korean Rural Genomic Cohort (KRGC) study. Written consent was obtained from the local ethical committee. Of these participants, 1437 were men (mean age 56.9 ± 7.9 years) and 2071 were women (mean age 55.8 ± 8.1 years). We measured GGT levels and various biochemical markers. To examine insulin resistance status, we used the homeostasis assessment method for insulin resistance (HOMA-IR). For inflammatory marker, we used C-reactive protein (CRP) levels. Results: Serum GGT levels were significantly higher in the MS group compared to the healthy patient group [23 (5-1403) vs. 19 (5-1920) IU/l; P = 0.01]. The prevalence of MS and adjusted relative risk were both significantly increased from the lowest to highest GGT quartiles; these results persisted after adjustments for multiple confounders. Positive correlations were established between GGT and HOMA-IR or CRP. Conclusion: These results suggest that GGT levels may be a surrogate marker of insulin resistance, inflammation and MS.
AB - Aims: To investigate associations between γ-glutamyltransferase (GGT) and components of metabolic syndrome (MS), insulin resistance and inflammatory markers in the Korean population. Methods: The 3508 subjects enrolled in this survey participated in the Korean Rural Genomic Cohort (KRGC) study. Written consent was obtained from the local ethical committee. Of these participants, 1437 were men (mean age 56.9 ± 7.9 years) and 2071 were women (mean age 55.8 ± 8.1 years). We measured GGT levels and various biochemical markers. To examine insulin resistance status, we used the homeostasis assessment method for insulin resistance (HOMA-IR). For inflammatory marker, we used C-reactive protein (CRP) levels. Results: Serum GGT levels were significantly higher in the MS group compared to the healthy patient group [23 (5-1403) vs. 19 (5-1920) IU/l; P = 0.01]. The prevalence of MS and adjusted relative risk were both significantly increased from the lowest to highest GGT quartiles; these results persisted after adjustments for multiple confounders. Positive correlations were established between GGT and HOMA-IR or CRP. Conclusion: These results suggest that GGT levels may be a surrogate marker of insulin resistance, inflammation and MS.
UR - http://www.scopus.com/inward/record.url?scp=41749110675&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41749110675&partnerID=8YFLogxK
U2 - 10.1111/j.1464-5491.2008.02415.x
DO - 10.1111/j.1464-5491.2008.02415.x
M3 - Article
C2 - 18346161
AN - SCOPUS:41749110675
VL - 25
SP - 469
EP - 475
JO - Diabetic Medicine
JF - Diabetic Medicine
SN - 0742-3071
IS - 4
ER -